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Biomedical subjects

M Bertrand

Publications and source records attributed to M Bertrand.

At least 199 records · Page 11Linked to original sources

A new method for the precise and complete correction of distortion on cineangiographic image: its effect on left ventricular measurements.

Some of the problems associated with the precise evaluation of left ventricular volumes from angiographic images are due to the magnification and distortion of the pictures obtained from X-ray equipment. Magnification errors can be evaluated easily but the distortion (due to pincushion effect) are more difficult to measure. A mathematical method is proposed for a complete point-by-point correction of errors due to magnification and X-ray distortion. This method is applicable to most currently used angiographic equipment. Since more and more angiographic images are processed with local or remote digital computers, the applicability of the proposed technique becomes realistic. Results from this study show that a 5-30% overestimation of usual geometric ventricular parameters is encountered if no correction is made for distortion. End-diastolic measurements are more affected than end-systolic ones because of the greater degree of spherical distortion at the periphery of the picture area.

Cardiac Volume↗

Acquisition by a pigtail macaque of behavior patterns beyond the natural repertoire of the species.

A female Macaca nemestrina was toilet trained at the age of 8 months and has learned to control urination at will. Giving is used by the monkey as a means of social manipulation but never in an altruistic context. An analysis of the constraints on learning to control elimination and to give in nonhuman primates shows that only certain components of these behaviors are contraprepared. A hypothesis for the origin of giving in Hominids is proposed, and attention is drawn to the opportunity for studying voluntary behavior in monkeys.

Animals↗

[General anesthesia for multiple dental extractions].

Between 1970 and 1975, 528 sessions of teeth extractions were carried out under general anaesthesia at the Ambroise Paré Hospital in Boulogne. The distribution was as follows: -70 multiple dental extractions in cardiac patients, mostly sent up by cardiology units outside the establishment. -458 multiple dental extractions for orthodontic treatment, germectomies, removal of included or supernumerary teeth, contra-indication or refusal of local anaesthetic. Since 1972, all patients for whom a surgical decision was considered were examined at the Anaesthetic out-patients and the advantages appear obvious. The type of premedication, the choice of the anesthetic technique were classical in the vast majority of cases and, in particular, intubation was carried out as a routine.

Adolescent↗

[Anesthesia and resuscitation in emergency maxillofacial surgery].

A series of 290 cases of maxillo facial trauma permitted the authors to draw up the indications for resuscitation and surgery. Restoration of the permeability of the airways is most often obtained by oral intubation under non-depressor pharmcological agents. The difficulties encountered during intubation were usually linked to pain, but sometimes had a mainly mechanical origin, particularly during zygomatic and malar bone fractures. Tracheotomy was exceptional. Hemorrhage was often the major obstacle and, in certain cases, could only be controlled by immobilisation of the fragments. The anaesthetic technique is very similar to that used in neurosurgery.

Anesthesia↗

[Aneurysm of the ascending aorta and aortic insuffiency].

Basing themselves on 24 cases of aneurysm of the ascending aorta with gross aortic incompetence, the authors give an account of their personal experience of this condition. They emphasise: -- the problems of aetiology posed by this annular dilation of the aorta with its associated elastic tissue dystrophy which is seldom apparent except at histological examination of the aortic wall at percuaneous biopsy; --the operative problems which confront the surgeon, especially because the orifices of the coronary vessels are in the very centre of the aneurysm. The detail their modest surgical experience, and emphasise the advantages of using Bentall's operation systematically; it seems that this is likely to be the operation of choice in the future.

Adult↗

Penfluridol steady-state kinetics in psychiatric patients.

Twenty-two hospitalized schizophrenic patients, participating in a large-scale phase II double-blind dose-effect study (30, 60, and 120 mg weekly) of penfluridol, a new diphenylbutylpiperidine neuroleptic, were maintained on a regular dosage regimen for 13 wk. Several blood samples were taken during the last dosage interval. Results show that the peak concentration develops within 12 hr after the last dose. A rapid decline, probably due to tissue re-equilibration, then occurs and is followed by a much slower falloff. Detectable concentrations 168 hr after administration are consistent with the long duration of action of penfluridol. Statistically significant differences between doses were found in the analysis of variance of plasma concentrations at all sampling times and in mean steady-state plasm concentrations. Wide differences in plasma concentrations were noted in patients receiving the same absolute dose, but a good relationship was defined between mean steady-state concentration and the dose expressed as mg per either kg of body weight or square meter of body surface area.

Administration, Oral↗

[Value of moderate fentanyl dosage during anesthesis in abdominal surgery. Apropos of 100 cases].

Fentanyl was used in 100 abdominal surgical interventions, combined with droperidol or with diazepan, always with good results as far as analgesia was concerned. Tensional variations that occurred during the induction were quite small and disappeared during the filling up. In the course of the intervention, tensional variations were only met with subjects suffering from high blood pressure. The respiratory depression that went with analgesia did not constitute an obstacle but made it necessary to use artificial ventilation for the intervetion. The awakening was always quick, smooth, without any vomiting and was influenced neither by the time taken up by the intervention nor by the condition of the patient. No residual respiratory depression requiring the use of an anti-morphinic was noted. At the end of the study, fentanyl appears as a powerful analgesic, easy to use and successful in all the cases of abdominal surgery. Its effect does not last, a drawback that can be avoided by the use of an intravenous drip.

Abdomen↗