Biomedical subjects

M Berger

Publications and source records attributed to M Berger.

At least 1,261 records · Page 70Linked to original sources

PubMedDate not supplied

[The current family situation from the child psychiatrist's viewpoint and its effects on the personality development of the child].

The report discusses three aspects of the modern family situation: 1. Stability and continuity of the current family situation in today's West Germany: the woman is subject to contradictory expectations from the society which seems to contribute to the ambivalence of the mother-child relationship as well as to the tendency of misinterpreting the child as a substitute for own needs. 2. Child abuse as an extreme example for a distorted family life: Exaggerated and illusionary presumptions about the child and the intact family life lead to traumatising experiences in the family. 3. Family and chronic illness of a child: Without the involvement and commitment of the family the scientific programs in medicine will not lead to advanced medical treatment.

Child↗

PubMedDate not supplied

Tissue and species specificity of mouse ductus deferens protein.

The ductus deferens of the mouse contains a major protein with a molecular weight of 34.5 kd called mouse vas deferens protein (MVDP). Immunofluorescence histochemistry and immunoblotting with monoclonal antibodies have been used to investigate the localization, tissue, and species distribution, androgen-regulation, and developmental expression of this protein. Consistent positive immunoreaction was achieved in the ductus deferens epithelium, and immunofluorescence revealed that spermatozoa from the deferent duct were coated with MVDP. Western blot analysis showed the organ specificity of MVDP, which could not be detected in several organs in the mouse. Furthermore, MVDP appeared to be species specific since the proteins extracted from the ductus deferens of man, rat, guinea-pig, rabbit, and hamster did not react with the anti-MVDP probe. MVDP, whose expression is regulated by testosterone, was detectable at 20 days of age and its concentration increased rapidly from 20-30 days.

Aldehyde Reductase↗

PubMedDate not supplied

[Cholestasis caused by an intradiverticular bezoar. Endoscopic treatment].

A 49 year old woman presented with fever. Blood chemistry showed cholestasis. Sonography and abdominal computed tomography showed a dilated biliary tract and a fluid collection in the head of the pancreas. A large, interposed, diverticulum of the second duodenum, filled with a bezoar, was documented by duodenoscopy. The bezoar was fragmented and removed by biopsy forceps. Retrograde visualization of the common bile duct then showed a normal biliary tree with good clearance of contrast material. The ulterior course was uncomplicated. This is the second reported case for cholestasis due to an intradiverticular bezoar in an interposed duodenal diverticula. Diagnosis and treatment were made by duodenoscopy.

Bezoars↗

PubMedDate not supplied

Suppression of lymphocyte proliferation by Pseudomonas aeruginosa phenazine pigments.

Pseudomonas aeruginosa culture supernatants have been shown to inhibit lymphocytes proliferation as measured by [3H]TdR uptake. The phenazine pigment pyocyanine has been identified as one of the inhibitors present in those supernatants. To determine the mechanism of the inhibitory action of P. aeruginosa supernatants and pyocyanine, we studied their effect on the early stages of T-cell activation. Both P. aeruginosa supernatant and pyocyanine inhibited lymphocyte stimulation induced by the lectin concanavalin A. Analysis of Interleukin-2 receptor expression on the T-cell membrane showed that it was inhibited by both. This inhibition is dose dependent and not due to cellular toxicity. There was a parallel inhibition of growth in cell volume as well as [3H]TdR uptake. The results reported here suggest that P. aeruginosa culture supernatant and purified pyocyanine may interfere with cellular immune responses that may be necessary for eradication of chronic infection with P. aeruginosa in patients with cystic fibrosis.

Antibodies, Monoclonal↗

PubMedDate not supplied

Four-year follow-up of retinal status and glycosylated haemoglobin in patients with insulin-dependent diabetes mellitus.

Retinal status and glycosylated hemoglobin (GHb) was followed in 32 patients with insulin-dependent diabetes mellitus (18 females; age upon entering the study 26 +/- 8 years; duration of diabetes 10 +/- 6 years; means +/- SD) during a total of 136 patient-years, i.e. during 4.3 +/- 0.6 years per patient. Annual mean GHb (given in percent of the mean normal GHb) was calculated from 7 +/- 3 determinations of GHb per patient-year. Fluorescein angiographs were performed at least once per patient-year, and retinal status was assessed by counting microaneurysms. Upon entering the study, early diabetic (background) retinopathy was present in 14 patients; at the end of the follow-up period, it was present in 20 patients. Retinal status deteriorated in 4/42 patient-years with excellent metabolic control (annual mean GHb less than or equal to 125%), in 13/70 patient-years with good control (annual mean GHb 126-150%) and in 8/24 patient-years with poor control (annual mean GHb greater than 150%). The incidence rate of retinal deterioration differed significantly between years with excellent control and years with poor control (X2 5.7, df = 1, p less than 0.05). It is concluded that excellent metabolic control within 14 +/- 6 years after onset of insulin-dependent diabetes mellitus appears to be a protective factor against the development or progression of early diabetic retinopathy.

Adult↗

PubMedDate not supplied