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Biomedical subjects

M Bauer

Publications and source records attributed to M Bauer.

At least 559 records · Page 31Linked to original sources
PubMed1984

[Nuclear magnetic tomography in cervical lymph node swellings].

Magnetic Resonance Imaging (MRI) and CT were performed in a patient suffering from carcinoma of the larynx with swollen cervical lymph nodes. MRI images in coronal planes give new diagnostic information about the spatial extension of pathologic findings and about the question of compression or infiltration of vessels. Exact topographic knowledge will be necessary. A subject of research is the differentiation between scar formation and tumour relapses.

Aged↗
PubMed1983

Relation of number of positive axillary nodes to the prognosis of patients with primary breast cancer. An NSABP update.

The current findings completely affirm the validity of our original observations indicating the appropriateness of grouping primary breast cancer patients into those with negative, 1 to 3, or greater than or equal to 4 positive nodes. Results, however, reveal that there is a risk in combining all patients with greater than or equal to 4 positive nodes into a single group. Since there was a 25% greater disease-free survival and an 18% greater survival in those with 4 to 6 than in those with greater than or equal to 13 positive axillary nodes, such a unification may provide misleading information regarding patient prognosis, as well as the worth of a therapeutic regimen when compared with another from a putatively similar patient population. Of particular interest were findings relating the conditional probability, i.e., the hazard rate, of a treatment failure or death each year during the 5-year period following operation to nodal involvement with tumor. Whereas the hazard rate for those with negative, or 1 to 3 positive nodes, was relatively low and constant, in those with greater than or equal to 4 positive nodes the risk in the early years was much greater, but by the fifth year it was similar to that occurring when 1-3 nodes were involved, and not much different from negative node patients. The same pattern existed whether 4 to 6 or greater than or equal to 13 nodes were positive. When the current findings are considered relative to other factors with predictive import, it is concluded that nodal status still remains the primary prognostic discriminant.

Axilla↗
PubMed1983

The simian-virus-40 large-tumor antigen in replicating viral chromatin. A salt-resistant protein-DNA interaction.

The large tumor antigen (T antigen) is a genome regulation protein, coded by simian virus 40, that binds with high affinity to specific binding sites on viral DNA. The specifically bound T antigen is released from these sites in 0.2-0.3 M NaCl. Immunoprecipitation techniques were used to show that T antigen also dissociates in 0.2-0.3 M NaCl from mature viral chromatin but not from replicating viral chromatin. In fact, a considerable fraction of T antigen remains associated with replicating chromatin at NaCl concentrations as high as 1.2 M NaCl when most chromatin proteins, including histones, dissociate. However, T antigen binding to both replicating DNA and mature DNA is sensitive to intercalating drugs such as caffeine and ethidium bromide. We consider the possibility that the unexpectedly tight binding of T antigen to replicating DNA is related to the function that T antigen performs during viral DNA replication.

Antigens, Neoplasm↗
PubMed1983

Papillon-Lefèvre syndrome.

A patient, with Papillon-Lefèvre syndrome, presented with a premature loss of both deciduous and permanent teeth and hyperkeratosis palmaris et plantaris. Other abnormalities such as psoriasiform hyperkeratosis, calcification of the falx, and frequent infections can be seen. Although no etiologic factor is known for this aberration, an autosomal recessive inheritance is established. Treatment usually consists of dental hygiene only since dermatologic therapy is usually unrewarding. A new finding resulted when fibroblasts from involved gingiva were compared with either uninvolved gingiva or controlled gingiva. The protein and collagen synthesis of the involved tissue was about twice that of the latter two groups.

Cells, Cultured↗
PubMed1983

Parenteral nutrition in preterm infants: influence of respiratory treatment and effect of different amino acid compositions.

Thirty-three premature infants receiving parenteral nutrition during the first 5 days of life were divided into three groups. Infants in group I (n = 13) received no ventilatory therapy. Those in groups II (n = 10) and III (n = 10) were intubated and artificially ventilated because of hyaline membrane disease, apnea, or other illness. All infants received glucose, amino acids, fat emulsion, and electrolytes in their total parenteral nutrition regimen. Groups I and II were administered a transfer-adapted amino acid solution (Aminoplasmal paed 5%) for their protein supplementation, and group III, a so-called human milk-adapted solution (Aminovenös 6%). The three groups were compared with respect to amino acid blood level, amino acid excretion, and nitrogen balance. Taurine levels decreased significantly during parenteral nutrition in all three groups. The other amino acids, with a few exceptions, remained within acceptable range. Elevations of serine, proline, and methionine were found in group III after the third day. All three groups exhibited good nitrogen retention. Excretion of amino acids was only about 1%.

Amino Acids↗
PubMed1983

Dexamethasone suppression test and depression in a rehabilitation setting.

A diagnosis of depression is frequently considered in the evaluation of patients after cerebrovascular accident (CVA); however, the usual clinical signs of depression may be either masked in depressed patients or mimicked in nondepressed patients. The dexamethasone suppression test (DST), first used to screen patients with a suspected diagnosis of Cushing's disease, has been shown in the psychiatric population to be abnormal in about 50% of patients with primary or endogenous depression. This study employed the DST to assess its diagnostic value in a population of 20 CVA patients admitted to a rehabilitation hospital. The test was found to have an 83% specificity. Results suggest that the low incidence of primary depression in this setting greatly limits the utility of the DST in such usage.

Cerebrovascular Disorders↗
PubMed1983

Dystrophy of Purkinje cell dendrites and vacuolar myelinopathy of the upper brain stem in young Turkish twin girls: secondary encephalopathy or genetic disorder?

Two Turkish twin sisters exhibited alteration of muscle tonus and coordination together with a disturbance of eye motility and a tendency toward central tonoclonic seizures at the age of 2 months. The two children died at the ages of 8 1/2 and 12 months. Microscopic findings in the cerebellum of one of the cases showed cactuslike thickenings of the Purkinje cell dendrites and grumose degeneration in the nucleus dentatus. In addition, vacuolar myelinopathy of the myelinated fiber systems of the upper brain stem was observed. A hereditary disorder of the central nervous system is discussed.

Brain Diseases↗
PubMed1983

[Effect of surgery and anesthesia on the plasma catecholamine level and rate of urea production in severely burned patients].

The influence of anaesthesia and operation on plasma catecholamine level (Group A) and on the production of urea (PU) (Group B) was investigated in two groups of severely burned patients. Plasma catecholamine levels increased at every operation. The increase of noradrenaline however was always higher than that of adrenaline. The elevation of NA in operations performed during the first week was significantly higher than in all later operations. The production of urea (PU) was chosen as a parameter of protein catabolism. The PU was measured on the day before the operation, on the operation day and on the 1st, 2nd and 3rd postoperative day. The highest mean values of the PU could be found on the 2nd and 3rd postoperative day, but the increase was less than expected. There was no difference in plasma catecholamine levels in PU between the different methods of anesthesia. The advantages and disadvantages of the methods of anaesthesia studied are discussed.

Adolescent↗
PubMed1982

Mixed chemodectoma-ganglioneuroma of the conus medullaris region.

Report of a 33-year-old man with a year-long history of low-back pain radiating into the left leg. Neurologic examination upon admission to the hospital revealed a spinal compression syndrome at the level L5. Laminectomy at L 4/5 revealed an encapsulated intradural tumor measuring 4 X 2.5 X 2.5 cm. The tumor was attached to the dorsal root L 4 and extended downward to the conus region. Light and electron microscopy revealed features mostly consistent with a mixed chemodectoma and ganglioneuroma.

Adult↗
PubMed1982

[Current reconstructive measures for the covering of defects in the extremities].

Large defects of soft tissue and bone in the lower extremity are still a great surgical problem with regard to morbidity and preservation of the leg. Conventional operative procedures such as cross leg or pedical flap are frequently not sufficient to guarantee successful treatment. Local muscle flap, myocutaneous flap and free-tissue transfer with microvascular anastomoses are excellent surgical supplements for better and quicker treatment, as they can generally be performed in one operative step. Strict indication and a specially trained operating team are essential for successful treatment in these more risky procedures. The new techniques and applications are demonstrated on various cases.

Adult↗
PubMed1982

[Subacute and subchronic percutaneous tolerance testing (28-day and 90-day test) of epicutaneously applied dis-infectants as demonstrated by the example of peroxyethanoic acid (author's transl)].

As compared to control animals, guinea-pigs to the shaved backs of which a dose of 0.16 ml of a 0.12% solution of PES/100g. of body mass had been applied twice daily for periods of 28 and 90 d, respectively (5 d of application being followed by 2 d without treatment), showed erythema, loss of hair, slower increase in mass, increased heart rate, smaller body mass/kidney mass and body mass/spleen mass ratios, increases in leucocytes, ASAT, ALAT, LDH I and LDH III. In the 28-d test, slight inflammatory symptoms of the liver, kidneys and heart were observed in the experimental animals. These symptoms were more marked in the 90-d test, granulomata in the livers being particularly striking. A pneumonia of moderate to very marked degree is suggestive of the activation of a clinically latent PES infect whereby the inflammatory alterations in the kidneys might be explained by the formation of metastases.

Acetates↗
PubMed1982

[Should splenic tissue be re-implanted after splenectomy due to birth trauma?].

Splenectomy results in loss of about 1/4 of the reticulo-endothelial system and 1/3 of the lymphatic tissue. Reduced phagocytosis and "clearing" capacity are reflected in the appearance of Howell Jolly bodies, thrombocytosis and decreased circulating immune-complexes. Reduction of IgM and compensatory increase of IgG and IgA levels further indicate immunological impairment. Transitory reduction of complement activity and the number of T-lymphocytes in the first weeks post-splenectomy constitute a significant limitation of immunological function and are accompanied by low serum tuftsin levels. These factors help explain the increased susceptibility to overwhelming infection seen in splenectomized patients. The lethality rate due to sepsis has been reported to be as high as 50%. Patients with hematological disorders, with systemic malignancies and children under 4 years of age who undergo splenectomy because of abdominal trauma are at especially high risk. The most common infectious agents are Haemophilus influenzae and Pneumococcus. The present report describes 2 infants who underwent splenectomy for the treatment of splenic rupture due to birth trauma. In one case, splenic tissue was homogenized and re-implanted; in the second case, splenectomy was followed by penicillin prophylaxis. The clinical course in the latter patient was complicated by Candida meningitis.

Bacterial Infections↗
PubMed1982

[Measuring of blood flow in replanted fingers with venous occlusion plethysmography].

From the first to the fourth year after replantation 12 patients were examined with a venous occlusion plethysmograph. The blood flow in the replanted digit was measured at 15 degrees C and 32 degrees C and compared with the blood flow of the corresponding healthy finger. The blood flow was found to increase during the first year and decrease thereafter. The possible causes for this change in the blood flow are discussed.

Female↗