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Biomedical subjects

M Bauer

Publications and source records attributed to M Bauer.

At least 541 records · Page 30Linked to original sources
PubMed1985

Thirty-year follow-up of ankle fractures.

The natural course of ankle fractures was studied in 143 patients treated by closed methods. The average time elapsing from fracture to follow-up was 29 years. Eighty-two per cent had no radiographic signs of arthrosis; 83 per cent were free of symptoms. The most common fracture, supination eversion Stage II (49 cases), gave rise to minimal signs of arthrosis in only one patient, who had moderate symptoms. The suggestion that all ankle fractures must be perfectly reduced is not supported by the findings of the present study.

Adult↗
PubMed1985

Malleolar fractures: nonoperative versus operative treatment. A controlled study.

Ninety-two intra-articular ankle fractures were randomly selected for either open reduction and internal fixation or closed reduction and plaster cast. The patients were followed for an average of seven years. The initial course was more favorable in surgically reduced fractures. However, follow-up examinations showed little difference in results between the two forms of treatment.

Adolescent↗
PubMed1985

[Contact therapy in the pharynx and oral cavity areas: after-loading technic, irradiation planning and results].

The contact irradiation in the region of pharynx and mouth with an afterloading unit is presented. Twelve patients with recurrent carcinomas of the squamous cell epithelium have been treated. A stable and reproducible positioning of the source probes in the tumor region is made possible by special applicator prostheses which are adapted to the post-operative situation. The irradiation scheme is based on the transformation of the source co-ordinates from the stereoradiographic localization system into the co-ordinate system of the computed tomogram. At least three fixed metal points which are inserted in the applicator prostheses and visualized by stereoradiography as well as by computed tomography serve as mutual reference points for both co-ordinate systems. The source positioning in the tumor region is optimized by CT irradiation planning. Three cases are presented in order to describe the principles of the method. Preliminary results are discussed.

Brachytherapy↗
PubMed1985

[Psychosocial follow-up of burn patients].

A questionnaire was developed to gain information on the medical, social and psychological rehabilitation of 62 burn patients. The questionnaire was answered by each patient and a close relative of their choice. The patients selected were those with burns involving hands and face, or with burns exceeding 30% of the body surface area. The returned questionnaires were analysed with respect to posttraumatic care, the extent of physical reconstruction, changes in personality and social behaviour, occupation, workman's compensation and cause of accident.

Adaptation, Psychological↗
PubMed1985

[Acrodermatitis chronica atrophicans--a borreliosis!].

Spirochetes were recovered from the skin lesions of two patients with acrodermatitis chronica atrophicans. Both patients assume that they had a tick bite. Sera from both patients showed increased IgG-antibody titers to a Borrelia burgdorferi strain isolated from the skin.

Acrodermatitis↗
PubMed1984

Comparison of melphalan with cyclophosphamide, methotrexate, and 5-fluorouracil in patients with ovarian cancer.

Melphalan (L-PAM) was compared to (C) cyclophosphamide, (M) methotrexate, and (F) 5-fluorouracil (CMF) in 413 patients with advanced ovarian carcinoma. L-PAM was given 3.5 mg/m2 twice daily for 5 days every 5 weeks. CMF doses were: C, 400 mg/m2; M, 15 mg/m2; and F, 400 mg/m2 IV on days 1 and 8 every 28 days. Three hundred seventy-five patients have been analyzed (L-PAM, 190; CMF, 185). One hundred fifty-three patients (41%) had measurable disease, 109 (29%) had evaluable disease, and 113 (30%) had nonmeasurable, nonevaluable disease. Response rates for patients with measurable and evaluable disease combined were similar: L-PAM, 32/130 (24%) (15% complete response); CMF, 47/132 (35%) (18% complete response). Patients with Stage IV measurable disease had a greater response rate to CMF, 22/52 (42%) versus L-PAM, 6/39 (15%). Survival and time to treatment failure were similar for both treatment regimens. Survival was improved in responders. Medians are: complete response, 28.1 months; partial response, 12.3 months; and no response, 6.7 months. Disease stage, performance status and age were identified as important prognostic variables for both survival and time to treatment failure.

Adenocarcinoma↗
PubMed1984

Hormonal dysregulations in severe burns.

Measurements of the concentrations of pituitary, thyroid and gonadal hormones have been made under both basal conditions and after adequate stimulation using a combined arginine TRH-LHRH stimulation test in 10 patients with deep burns covering between 30 and 70 per cent of the body surface during the first 20 days after injury. The most remarkable changes were found in the pituitary-gonadal system with testosterone concentrations significantly decreased at all times during the periods of study. Stimulation with LHRH resulted in a prompt response of FSH and LH during the first 10 days after burning whereas between 10 and 20 days after injury the basal concentrations for both hormones were significantly lower and showed a delayed response to stimulation. During the period of early fluid therapy large amounts of glucose without additional insulin were given, resulting in elevated blood glucose and high plasma insulin levels. It is concluded that normal pancreatic insulin production is sufficient to avoid excessive hyperglycaemia even during the period soon after burning. Compared with the findings in control patients the HGH levels in burned patients were not significantly different at any time during the periods of study.

Adolescent↗
PubMed1984

The influence of radiation therapy on T-lymphocyte subpopulations defined by monoclonal antibodies.

We studied the influence of radiation therapy on lymphocyte subpopulations in 17 patients undergoing adjuvant radiation therapy for primary breast cancer, and eight patients receiving brachytherapy and external beam irradiation for primary cancer of the uterus. Radiation therapy reduced B- and T-lymphocytes in proportion to the total lymphocyte population so that their percentages remained unchanged. Determination of helper and suppressor T-lymphocytes before, during and 6 months after completion of radiotherapy revealed that in both groups of patients suppressor T-lymphocytes were more resistant to and recovered faster after radiotherapy. This resulted in a decline of the "immunoregulatory balance" (helper/suppressor ratio). Although this ratio had been higher in both groups of patients than in healthy age- and sex-matched controls before therapy, it became normal and subnormal during and after radiotherapy. The clinical significance of the differential influence of radiotherapy on T-lymphocyte subpopulations remains to be determined.

Adult↗
PubMed1984

Long-term development of a primary lung sarcoma, probably lymphangiosarcoma--a case report.

A small primary lung lesion had remained unchanged in size over a period of 8 years. Within the ensuing 2 years rapid tumor growth occurred. On operation the surgical specimen revealed a tumor mass of 87.2 cm3. Within 6 months after resection, the tumor occurred on the same side. Extensive tumor infiltration of the chest wall prevented any further surgery. The histo-morphologic picture of both lesions was consistent with a lymphangiosarcoma without evidence of high grade malignancy. The patient died of cardio-respiratory insufficiency due to extension of the tumor mass. Unfortunately no autopsy was performed. Tumor growth rates, macroscopic reconstruction and electron microscopic evaluations are presented. This case report again points out that size and long-time stability of solitary lung nodules are not necessarily reliable criteria for assessing prognosis.

Adult↗
PubMed1984

[Multiple Cancers].

According to the criteria of Warren and Gates the course of disease of 11972 patients--8099 of them carcinomas under treatment in the Universitäts-Strahlenklinik--were examined in respect to multiple malignomas. In 232 cases such multiple malignomas were diagnosed, corresponding to 2.86%. We found more women (3.49%) than men (2.13%). In 165 cases (67.2%) multiple malignomas appeared metachronically, i.e. after an interval of more than 2 years, 76 (32.8%) of those patients were synchronic multiple malignoma--carriers. In women we found with 3.49% significantly more often metachronic manifestations than in men (2.13%). According to synchronic multiple malignomas we stated that they are to be found in males and females in an equal amount. On the average the second malignoma appeared in males and females 10 years after diagnosis of the primary tumor. Localizations of the multiple malignomas as well as combinations of certain tumors are shown and discussed.

Adult↗
PubMed1984

Staphylococcal alpha-toxin elicits hypertension in isolated rabbit lungs. Evidence for thromboxane formation and the role of extracellular calcium.

Staphylococcal alpha-toxin is known to damage mammalian cell membranes. Studies of erythrocytes indicate that the native toxin generates a discrete transmembrane channel with an effective diameter of 2-3 nm. (Füssle, R., S. Bhakdi, A. Szeigoleit, J. Tranum-Jensen, T. Kranz, and H.J. Wellensiek. 1981. J. Cell Biol. 91:83-94.) In isolated rabbit lungs, perfused with recirculating blood- and plasma-free perfusion fluid, the mediation of a toxin-provoked vascular pressor response by the triggering of the arachidonic acid cascade and its dependence on extracellular calcium were investigated. Dose-dependent pulmonary artery pressor responses were elicited by the injection of 0.5-5 micrograms staphylococcal alpha-toxin into the pulmonary artery. The pressor responses were completely abolished by preincubation of the toxin with neutralizing antibodies or by preformation of alpha-toxin hexamers in vitro. They were accompanied by the release of the arachidonic acid metabolites thromboxane B2 and 6-keto-prostaglandin F1 alpha (stable metabolites of thromboxane A2 and prostaglandin I2, respectively) into the perfusion fluid. They were blocked by inhibitors of thromboxane synthetase, cyclooxygenase, and phospholipase, as well as by substances that interfere with calcium-calmodulin function. alpha-Toxin induced selective release of potassium, but not lactatedehydrogenase into the medium. Calcium depletion of the intravascular space did not suppress the toxin-dependent potassium release but did abrogate the pressor response and the release of the arachidonic acid metabolites. When calcium was reintroduced into the circulation without the application of a second toxin stimulus, marked pressor responses paralleled by the release of arachidonic acid metabolites occurred. The conclusion drawn from these studies is that staphylococcal alpha-toxin provokes pulmonary vascular hypertension which is apparently mediated by thromboxane A2 formation, which surpasses the biological effect of the simultaneously formed prostaglandin I2. The triggering of the arachidonic acid cascade is strictly dependent on extracellular calcium and may be mediated by a nonphysiological calcium bypass through transmembrane toxin channels with subsequent stimulation of phospholipase activity.

Animals↗
PubMed1984

Width of the normal ankle joint.

An investigation of the talocrural joint was performed in 160 normal adults, 80 males and 80 females. The joint space was measured on films at six locations, three in the antero-posterior and three in the lateral view of the ankle. The average joint space in men was 3.4 mm and in women 2.9 mm, which is a significant difference (p less than 0.001). The joint space was wider in the medial part when evaluating the antero-posterior view, but did not change with age.

Adolescent↗
PubMed1984

[Nuclear magnetic resonance in the Hallervorden-Spatz syndrome].

Two patients (mother and son) with Hallervorden-Spatz's syndrome were examined both via CT and Nuclear Magnetic Resonance (NMR), using different measuring modes. In the patient with progressing disease pathological findings were seen in the right and left putamen with CT and NMR. All examinations in the mother with a less progressive syndrome were without any result. Information obtained via NMR did not yield significantly more relevant data than computed tomography.

Adolescent↗