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Biomedical subjects

M Baratz

Publications and source records attributed to M Baratz.

86 records · Page 5Linked to original sources
PubMed1974

Gardner's syndrome: report of a family.

Two cases of Gardner's syndrome in one family are presented. The father presented all three stigmas of the syndrome, while in the daughter no osseous manifestations were found. In the first patient, the diagnosis was made only after the second abdominal operation, when a mesenteric fibrous mass was seen. In the second case, the intestinal polyposis was clinically suspected, considering the hereditary aspects of this syndrome, and the episode of bloody diarrhea presented by this patient. Both patients were treated by subtotal colectomy with ileo-rectal anastomosis. Both of them presented fibrous tumors after the abdominal operation (the father after six years and the daughter after one year). The authors stress the importance of postoperative followup for the detection of fibrous masses that may appear due to the surgical stimulus. The literature on Gardner's syndrome is reviewed and summarized.

Adolescent↗
PubMedDate not supplied

Radioimmunoguided surgery benefits for recurrent colorectal cancer.

BACKGROUND: Despite new adjuvant therapy, 50% of patients with colon cancer will have recurrent disease. This study investigated the use of a radiolabeled monoclonal antibody in locating occult tumor during surgery for recurrent colorectal cancer. METHODS: Twenty-two patients with recurrent colorectal cancer underwent surgery using the radioimmunoguided surgery (RIGS) system. All patients were subjected to abdominal and chest computed tomography (CT). Before surgery, patients were injected with the CC49 monoclonal antibody (MoAb), anti-TAG antibody labeled with 125I. Ten patients with elevated carcinoembryonic antigen (CEA) levels and no CT findings had a scintigraphy scan with an anti-CEA MoAb labeled with 99Tc. Human antimouse antibody levels of these patients were within normal limits. Surgical exploration including liver ultrasound examination was followed by survey with a gamma-detecting probe (GDP). RESULTS: There was MoAb tumor localization in 100% of the patients. CT found nine tumor sites, traditional surgical exploration 30, and the GDP 51, with 44 confirmed by pathology (hematoxylin and eosin). The RIGS system found occult tumor in 10 patients (45.4%) and resulted in major changes in surgical procedure in 11 patients. In the 10 patients who had scintigraphy scans, 10 tumor sites were identified, whereas RIGS found an additional eight sites. CONCLUSION: RIGS technology offers a substantial benefit for patients undergoing surgery for recurrent colorectal cancer and a better chance of finding recurrent tumor intraoperatively in patients who have elevated CEA levels with no other CT findings.

Abdominal Neoplasms↗
PubMedDate not supplied

Irradiation-induced colonic stricture and colitis cystica profunda: report of a case.

A 57-year-old patient was operated upon for a colonic stricture that appeared 18 years after removal of a clear-cell carcinoma of the kidney, followed by irradiation therapy. In addition to typical irradiation-induced changes and fibrotic stricture, colitis cystica profunda was discovered. Review of the literature showed no similar case.

Colitis↗
PubMedDate not supplied

Leiomyosarcoma of the colon and rectum.

Leiomyosarcoma of the colon is an uncommon lesion and may appear throughout the colon. Early diagnosis is seldom accomplished before complications such as bleeding or obstruction appear. Sometimes it is histologically difficult to distinguish between a benign and a mlaignant leiomyoma. Some leiomyomas have biologic evidence of malignancy. Five cases of leiomyosarcoma are described, one of which was histologically diagnosed as a leiomyoma, but two years later, at laparotomy, metastases were found.

Adult↗
PubMedDate not supplied

Rectal bleeding due to amebic colitis diagnosed by multiple endoscopic biopsies: report of two cases.

Recurrent rectal bleeding over a period of seven and 12 months, respectively, was the main and unusual manifestation of amebic colitis in two patients. The difficulty in establishing the diagnosis led to one patient's receiving potentially dangerous steroid therapy. Only by taking multiple colonoscopic biopsies was the amebic colitis recognized. This and serologic tests, should be routine in all cases of inflammatory bowel disease before initiating therapy.

Adolescent↗
PubMedDate not supplied

Endoscope-induced colitis: description, probable cause by glutaraldehyde, and prevention.

Six cases of acute, self-limited colitis that occurred after screening flexible sigmoidoscopy were deduced to be iatrogenic, probably caused by glutaraldehyde residues in the endoscopes after disinfection in an automatic disinfecting machine. The concentration of these residues was indirectly estimated by conductivity measurements of electrolyte concentration in the rinse-water tank of the disinfecting machine during and after five cycles and also in fluid remaining on the surface of the endoscopes and in the endoscope channels. After five cycles, residues in both the rinse water and fluid in the endoscope channels contained the equivalent of 0.2% glutaraldehyde. This was the result of a combination of technical and human errors. It can be prevented by changing the rinse water after each cycle, using forced air to dry the instruments, and washing the endoscopes before use. Users of the automatic disinfecting machine should be aware of the potential accumulation of toxic levels of residues that remain in endoscopes after disinfection.

Acute Disease↗
PubMedDate not supplied

Mediterranean lymphoma -- an unusual course.

A case of Mediterranean lymphoma with an unusual short and stormy course complicated by spontaneous perforation of the small bowel in a 32-year-old Jewish Moroccan-born male is presented. Such a course has not been described previously. Literature pertinent to the subject is reviewed.

Adult↗
PubMedDate not supplied

Induction of acute synovitis in the rat by human interferon.

Intra-articular injection of human interferon (alpha, beta or gamma) into rat knee joints induced increases in knee diameter, synovial effusion and synovial membrane weight. An inflammatory cell infiltrate was also noted in synovial membranes. Hydrocortisone diminished the inflammatory response when injected together with interferon. Mouse beta interferon did not produce synovitis in rat knees. These results further support the hypothesis that interferon may play a role in the pathogenesis of human arthritis.

Animals↗
PubMedDate not supplied

Stimulation of prostaglandin E production by rat synovium induced by intraarticular injection of measles virus.

Measles virus was injected into the joints of rats. Prostaglandin E in organ cultures of synovial tissue removed from injected joints was evaluated. A 9-fold increase of prostaglandin E concentration was found in cultures of synovial membranes from joints injected with measles virus as compared to controls. Histologic examination revealed inflammation in the synovial membranes of joints injected with virus. We suggest that prostaglandin E may mediate joint inflammation induced by measles virus.

Animals↗