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Biomedical subjects

M Baldini

Publications and source records attributed to M Baldini.

At least 73 records · Page 4Linked to original sources
PubMed1989

Selenium intake with diet in Italy: a pilot study.

Selenium is an element essential to man. The main environmental pathway of Se-exposure for the general population is through food. As is true for all essential elements, not only deficient but also excessive exposure results in adverse health effects. Between these extremes there is a range of safe and adequate Se intakes. In 1980 the Italian National Research Council recommended 50-200 micrograms/day as an interval adequate to meet nutritional requirements, being at the same time below the threshold of toxic effects. Therefore the evaluation of dietary Se intake has become very important. The purpose of this work is the estimation of dietary intakes of Se using data on the amount and composition of an average Italian diet. Complete meals from a factory canteen were analyzed and calculations of weekly intake of Se carried out. Analyses were performed by means of Inductively-coupled Plasma Atomic Emission Spectrometry. The results obtained, related to the average and indicative food consumption of Italian people, showed that the daily intake is well within the recommended range.

Diet↗
PubMed1988

Effect of methyldopa on prolactin serum concentration. Comparison between normal and sustained-release formulations.

In a group of ten hypertensive patients, the effects of methyldopa administration in two different formulations on serum prolactin (PRL) were studied. A single oral dose of normal release methyldopa significantly increased serum prolactin levels, peak concentrations occurring 3 to 6 h after drug administration. On the contrary, administration of sustained release methyldopa at the same dose was only followed by slight and not significant fluctuations in prolactin plasma levels. Both formulations produced a significant decrease of systolic and diastolic blood pressures, without significant differences between sustained and normal release methyldopa effects.

Adult↗
PubMed1986

Improvement of diabetes after treatment with somatostatin analogue SMS 201-995 in an acromegalic patient.

The beneficial effects of long acting somatostatin analogue SMS 201-995 in an acromegalic patient affected by severe diabetes mellitus are reported. Neither human insulin alone nor human insulin plus bromocriptine allowed satisfactory metabolic control though, with the latter treatment, virtually normal plasma GH levels were reached. Conversely, addition of SMS 201-995 to insulin treatment led to normalization of blood glucose. This result was obtained with a dose of SMS 201-995 of 400 micrograms/day and only after 3 weeks of therapy.

Acromegaly↗
PubMed1985

Direct imaging of live human platelets by flash x-ray microscopy.

A 100-nanosecond pulse of long-wavelength x-rays was used to produce high-resolution stop-motion images of living human platelets. Although some aspects of the structure conform to those seen in dehydrated specimens, novel features are apparent. The technique should permit detailed stop-motion examination of the interaction of platelets with their surrounding medium as well as exploration of the phagocytic and secretory activities of a wide variety of other cells.

Blood Platelets↗
PubMed1985

Haemangioblastoma of the brain. Computed tomography and angiographic studies in 17 patients.

Between 1975 and 1983, 17 patients who underwent surgery for haemangioblastomas of the brain (16 lesions occurring in the posterior fossa) were studied with CT scans (17 cases) and vertebral angiograms (15 cases). The CT scans were superior for demonstrating a cystic tumour, its topography in the posterior fossa, its relationship to the fourth ventricle, and the presence and degree of an obstructive hydrocephalus. The vertebral angiographies were more sensitive and specific than CT for revealing the vascular nature, and were imperative in order to establish the supply and drainage of the tumours. It is clear that CT and angiography each make an important contribution toward defining these tumours. Their association is necessary.

Adolescent↗
PubMed1985

Evidence for differing dopaminergic activity in childhood- or adult-onset obesity.

In order to investigate dopaminergic activity in two types of human obesity, childhood- and adult-onset, we have studied the responses of plasma TSH and prolactin to domperidone, a dopamine receptor antagonist, in 12 patients obese since early childhood, 12 patients with adult-onset obesity, and in 12 lean controls. All subjects were females. In childhood-onset obese patients the responses of plasma prolactin and TSH to antidopaminergic stimulation were lower than those of adult-onset obese patients and lean controls. Conversely, the stimulus elicited a normal response of plasma prolactin and an exaggerated response of plasma TSH in adult-onset obese patients. These data indicate the presence of differing dopaminergic tone in the two types of human obesity.

Adolescent↗
PubMed1984

Gonadotropin response to gonadotropin releasing hormone in acute schizophrenia.

To evaluate hypothalamic-pituitary-gonadal axis in acute schizophrenia, plasma FSH and LH concentrations were estimated both in basal conditions and after stimulation with gonadotropin releasing hormone (GnRH, 200 micrograms i.v.) in 14 young male patients with acute schizophrenia and in a age-matched group of 14 healthy male controls. Basal plasma PRL and testosterone levels were also measured. The mean basal levels of LH and FSH were slightly lower in schizophrenics, while the mean testosterone and prolactin levels were similar in the two groups. The FSH response to GnRH was significantly reduced in patients with acute schizophrenia, while the response of LH was similar in schizophrenics and in the controls. The possible significance of these findings is discussed in the contest of the complex neuroendocrine regulation of gonadotropin secretion and the overactivity of dopaminergic systems in acute schizophrenia.

Acute Disease↗
PubMed1983

Intrasellar meningioma.

Two purely subdiaphragmatic intrasellar meningiomias are described. The rarity of this unusual intrasellar tumor is stressed, and the differential diagnosis of intrasellar meningioma versus pituitary adenoma is discussed. The good results of the rhinoseptal route for surgery are emphasized.

Adenoma↗
PubMed1982

Meralgia paraesthetica following weight loss. Case report.

The authors report on a case of persistent meralgia paraesthetica of the left side, following a weight loss of 8 kg in one month. Not only volumetric changes of the panniculus adiposus in the inguinal region but also a slight arrangement of the inguinal ligament and a state of undernourishment contribute to the compression of the lateral femoral cutaneous nerve. By microsurgical epineurectomy and interfascicular neurolysis the disappearance of the meralgia and preservation of the sensation on the antero-lateral aspect of the thigh are obtained.

Adult↗
PubMed1981

Diagnostic value of objective campimetry.

The results obtained in ten normal subjects with a new method of pupillocampimetry are described and compared with those obtained with routine campimetry. Once the relationship between the two methods was established, ten subjects suffering from pregeniculate or postgeniculate lesions of the optic pathways were examined by pupillocampimetry. This study shows the value of this new method, particularly for the differential diagnosis of pre- or postgeniculate lesions.

Adaptation, Ocular↗
PubMed1980

Charcterization and measurement of normal platelet-associated immunoglobulin G by fluorospectrophotometry.

Platelet-associated immunoglobulin G of normal healthy subjects was measured and its binding characteristics studied by use of a newly developed assay which is rapid, quantitative, sensitive and inexpensive. The assay is based on fluorospectrophotometry. Fluorescein isothiocyanate was used as a fluorescent marker to label IgG. Measurement of platelet-associated IgG by this method showed that normal platelets have at least two types of binding sites for IgG of normal healthy subjects. High- and low-affinity binding sites numbering 410 +/- 200 and 1800 +/- 500, respectively, were identified. Specificity of binding was shown by competition between fluorescein isothiocyanate-labeled IgG and nonlabeled IgG. The effect of pH and temperature and the kinetics of binding were also investigated.

Binding Sites↗