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Biomedical subjects

M Baba

Publications and source records attributed to M Baba.

At least 847 records · Page 47Linked to original sources
PubMed1982

Bile reflux: a possible cause of stomach ulcer in nontreated mutant mice of W/WV genotype.

The chronic antral ulcer developed spontaneously in (WB X C57BL/6)F1-W/WV mice. Natural history of the ulcer was investigated to make clear the mechanisms involved in the development of ulcer in this mutant mouse. Although no histopathologic abnormalities of the stomach were detected at the fifth day after birth, erosions developed at the tenth day and the severity of the ulcerative lesions advanced with age. Antral pH of the W/WV mice was higher than that of the congenic +/+ mice, and the content of gastrin in the glandular stomach of the former was lower than that of the latter. Therefore, hyperacidity cannot be the cause of the ulcer in the W/WV mice. Bilirubin was demonstrable in the stomach contents of the suckling W/WV mice. After subcutaneous injection of [35S]sulfobromophthalein, the 35S radio-activity in the stomach contents of the 10-day-old W/WV mice was about 40 times as great as that observed in the +/+ littermates. As the peak of the bile reflux occurred shortly before the development of obvious ulcer that penetrated beyond the muscularis mucosae, the bile reflux could be a cause rather than a result of the ulcer.

Animals↗
PubMed1982

[Penetrating transorbital intracranial foreign body].

About a month prior to admission to our hospital, a 25-year-old man had a quarrel with his friend and was stabbed in his left eye with a cracked bottle of beer. He underwent emergency operation for the injured left eye. Subsequently he was admitted to an ophthalmological ward in our hospital for plastic surgery of an artificial eye. An intracranial foreign body was pointed out, and he was soon transferred to our neurosurgical ward. Plain x-ray films and tomograms of the skull and CT scan showed a foreign body at medial portion of the left superior orbital fissure. Carotid angiography revealed no significant implication of the cerebral vessels. As there was a strong suspicion of cerebral contusion or liquorrhea, a pterional craniotomy was so designed as to do removal of thie foreign body and repair of the dura mater in one stage. The post-operative couse was uneventful without liquorrhea or miningitis. It was emphasized that pterional approach used by Hamby (1970) for surgery of malignant exophthalmos was useful and felicitious in this case. It was additionally reported that cerebrospinal orbitorrhea observed in this case was rare and it might be the third case in the literature.

Adult↗
PubMed1981

Electrocochleographic study of patients with cerebral vascular lesions.

Electrocochleographies were performed on three patients with deafness resulting from cerebral vascular lesions. Recording was made by the transtympanic needle electrode technique. In a patient who had anterior-inferior cerebellar artery aneurysm that showed fluctuating hearing loss, auditory nerve action potential (AP), cochlear microphonics (CM), and summating potential fluctuate in amplitude in concert with episodes of ischemic hearing loss. This indicates the pathophysiology of reversible impairment of the cochlear nerve and of sensory epithelium of the inner ear caused by disturbance of blood flow into the inner ear. It was also conjectured that the cochlea is hardly impaired in the case with normal AP and CM responses despite the increased threshold in pure-tone audiometry and that the cochlea undergoes irreversible organic changes in the patient who has no AP or CM response in tests after a long period.

Action Potentials↗
PubMed1981

Anticomplement immunofluorescence for the titration of antibody to varicella-zoster virus.

Anticomplement immunofluorescence (ACIF) was tested for its use for the titration of antibody against varicella-zoster virus (VZV). ACIF antibody responses of patients with VZV infection were specific for VZV antigen and heterotypic responses to herpes simplex virus type-1 and cytomegalovirus antigens were not observed. Comparative studies of ACIF, membrane immunofluorescence (MIF) and indirect immunofluorescence (IF), using acetone-fixed antigen, were carried out with nonimmune sera and convalescent sera of patients who had recovered from varicella, herpes zoster and Rumsey Hunt disease. Nonspecific staining occurred with some nonimmune sera at a 1:4 dilution in the MIF and IF tests, after freezing and thawing of the serum, but not in the ACIF test. The antibody titers in convalescent sera agreed well in these three methods and the highest titer was obtained by MIF. The titers in ACIF and IF were similar but the ACIF antibody decreased earlier than the IF antibody during convalescence. On the other hand there was a discrepancy between the titers of ACIF and those of MIF and IF antibody in the sera of healthy adults, all sera with titers higher than 10 in the MIF and IF tests had titers below 10 in the ACIF test. The average titer of ACIF antibody declined to less than 10 with increasing age (13 to more than 20 years), whereas the MIF antibody increased during the same period of life.

Adolescent↗
PubMed1981

[Canine parvovirus infection in a group of beagles (author's transl)].

An outbreak of canine parvovirus infection in a group of 26 beagles was described. The disease characterized by acute intestinal involvement was highly contagious but fatality was low (1/26). Transient leukopenia was recorded in some animals. All the convalescent sera were positive in agar gel diffusion test using feline panleukopenia virus antigen. Histopathological examination on fetal dog revealed regressive change associated with formation of amphophilic intranuclear inclusion bodies in the enterocytes of the Lieberkühn's crypt and regressive change in the lymphoid tissues. Pathologic picture exhibited strikingly resemblance with that of feline panleukopenia.

Animals↗
PubMed1981

Time-dependent changes in open-loop gains of baroreflex systems after massive hemorrhage.

To quantify the effects of massive hemorrhage (5 ml/kg body weight) on the individual arterial baroreflex systems in the dog, changes in the open-loop gains of the intact arterial pressure control system (Gintact), the carotid sinus baroreflex system (GCS), and the vagally mediated and aortic arch baroreflex systems (GV) were measured repeatedly from the response to quick mild hemorrhage (2 ml/kg body weight) before and after massive hemorrhage. Fifteen mongrel adult dogs were divided into 3 groups. i.e., the control, vago-aortic nerve-severed, and carotid sinus-denervated groups. The dogs anesthetized with Nembutal (35 mg/kg body weight) were bled by 2 ml/kg body weight within 2 sec through a catheter inserted into the abdominal aorta. The arterial pressure change after mild hemorrhage was monitored via a catheter placed in the aortic arch. The open-loop gain of the baroreflex system was assessed as (delta API/delta APS--1), where delta API and delta APS are the immediate and steady-state falls in arterial pressure following mild hemorrhage. The mean values of Gintact, GCS, and GV before massive hemorrhage were 7.8, 2.0, and 1.8, respectively. Since Gintact is not a simple summation of GCS and GV, it is speculated that the carotid sinus baroreflex system interacts in a facilitatory way with the vagally mediated and aortic arch baroreflex systems. After massive hemorrhage, Gintact changed along a time course of parabolic form, whereas GCS did not change and GV decreased. These results suggest that the time-dependent change of Gintact after massive hemorrhage depends on the change in the open-loop gain of the baroreflex system making a facilitatory interaction.

Animals↗
PubMed1981

Inhibition of gastrin secretion by pirenzepine (LS 519) in treatment of gastric ulcer.

The effects of pirenzepine on the serum gastrin levels in the basal state and in response to a liquid test meal were investigated in nine patients with gastric ulcer. Single-dose administration of the drug caused a significant decrease in the basal gastrin level and significant inhibition of the serum gastrin response. When measured 12 h after the end of drug treatment for 7 days, the serum gastrin levels in the basal state and in response to a test meal tended to be high, but the differences were not statistically significant.

Adult↗