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Biomedical subjects

M B Stern

Publications and source records attributed to M B Stern.

64 records · Page 4Linked to original sources
PubMedDate not supplied

Attention and sentence processing deficits in Parkinson's disease: the role of anterior cingulate cortex.

Parkinson's disease (PD) is a complex neurodegenerative condition involving a motor disorder that is related to reduced dopaminergic input to the striatum. Intellectual deficits are also seen in PD, but the pathophysiology of these difficulties is poorly understood. Regional cerebral blood flow (rCBF) was studied in neurologically intact subjects during the performance of attention-demanding, sentence processing tasks using positron emission tomography (PET). The results demonstrated significantly increased rCBF in a distributed set of cerebral regions during the detection of an adjective or a particular agent in a sentence, including anterior cingulate cortex, left inferior and middle frontal cortex, left inferior temporo-occipital cortex, posterolateral temporal cortex, left caudate, and left thalamus. We identified defects in this cerebral network by studying PD patients with two PET techniques. Resting PET studies revealed a significant correlation between regional cerebral glucose metabolism in anterior cingulate cortex and deficits in attending to subtle grammatical aspects of sentences. Studies of PD patients with the PET activation technique revealed little change in anterior cingulate and left frontal CBF during performance of the adjective detection or agent detection tasks. These data suggest that a defect in anterior cingulate cortex contributes to the cognitive impairments observed in PD.

Aged↗
PubMedDate not supplied

Femoral neuropathy as a complication of heparin anticoagulation therapy.

Femoral nerve compression by retroperitoneal hematoma is an uncommon but significant complication of Heparin anticoagulation. The orthopedic surgeon today, utilizing anticoagulation more frequently than ever, must be ever mindful of the early warning signs and symptoms of this syndrome.

Adult↗
PubMedDate not supplied

Intratendinous ganglionic cyst.

The authors present a review and case presentation of an intratendinous ganglionic cyst. This rare entity is discussed with emphasis on its pathogenesis, microscopic anatomy, and clinical occurrence to aid in the differential diagnosis with other cystic type lesions that may occur in the foot. A case report is presented to demonstrate this unusual lesion, and the surgical approach used to excise the affected peroneus brevis tendon.

Adult↗
PubMedDate not supplied

The anterior interosseous nerve syndrome (the Kiloh-Nevin syndrome). Report and follow-up study of three cases.

Three surgically treated cases demonstrate that this syndrome is a compressive neuropathy of the anterior interosseous branch of the median nerve rather than a neuritis, as originally believed. All symptoms were in the dominant hand and included deterioration of handwriting, pain, weakness of the flexor policis longus, the flexor digitorum longus to the index finger, and the pronator quadratus. Electromyograms were abnormal in two of the three cases. All forms of conservative treatment failed over a three- to five-month period. All lesions were demonstrable at surgery, and recovery was complete in all cases within five months of surgery. At an average follow-up evaluation of seven years there was no recurrence in any case. The loss of ability to write was characteristic of all three cases and is being reported for the first time.

Accidents, Occupational↗
PubMedDate not supplied

Eosinophilic granuloma of the proximal tibial epiphysis.

This is a 3-year follow-up report of an eosinophilic granuloma of bone occurring in a growing epiphysis. The lesion occurred in a 6-year-old boy and is only the third such case reported in the literature. Eosinophilic granuloma should be considered in the differential diagnosis of lytic lesions of the epiphysis in childhood.

Child↗