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Biomedical subjects

M B Stern

Publications and source records attributed to M B Stern.

At least 55 records · Page 3Linked to original sources
PubMed1989

Parkinsonism secondary to bilateral striatal fungal abscesses.

A 24-year-old man with an 11-year history of i.v. drug use rapidly developed parkinsonism clinically indistinguishable from MPTP toxicity and Parkinson's disease. Although tests were negative for the human immunodeficiency virus, radiologic evaluation revealed bilateral striatal lesions. Stereotactic biopsy demonstrated septate hyphae consistent with either aspergillosis or mucormycosis. Gradual improvement followed systemic therapy with amphotericin B.

Adult↗
PubMed1989

Magnetic resonance imaging in Parkinson's disease and parkinsonian syndromes.

High field strength magnetic resonance imaging (MRI) provides a noninvasive means of evaluating patients with parkinsonism. Using strict clinical criteria, we began a prospective study of patients with Parkinson's disease (PD) and parkinsonian syndromes (PS) including progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and atypical parkinsonism (ATYP). We detected moderate to severe putaminal hypointensity more frequently in PS than in PD and controls, although putaminal hypointensity did not distinguish between MSA, PSP, or ATYP. Signal intensity in the lateral substantia nigra did not differ significantly among patients with PD, PS, or controls and was therefore not a useful MRI marker. Pars compacta width was significantly narrower in both PD and PS. Subcortical and periventricular hyperintense foci were more abundant in PD and PS than controls. Atrophy of the brainstem occurred only in patients with PS.

Aging↗
PubMed1989

MR imaging of Parkinson disease with spin-echo and gradient-echo sequences.

High-field MR with both spin-echo and gradient-echo sequences was performed in 21 patients with (idiopathic, drug-responsive) Parkinson disease. The use of gradient echoes allowed more sensitive detection than did spin echoes of susceptibility changes in the putamina and substantia nigra. No statistically significant difference in putaminal hypointensity on long TR/long TE spin-echo sequences or on T2*-weighted images using gradient-echo sequences was observed between Parkinson patients and controls. There was also no statistically significant difference in the frequency of restoration of the signal intensity of the substantia nigra between the two groups of patients. The width of the pars compacta of the substantia nigra in patients with Parkinson disease was 2.12 + 0.82 mm (mean +/- SD). This value in age- and gender-matched controls was 2.67 +/- 0.5. Comparing these two groups with an unpaired t test resulted in a p value less than or equal to .005. Our MR study with spin-echo and gradient-echo images in Parkinson and control patients was able to substantiate and elaborate on previously described MR features of Parkinson disease.

Adult↗
PubMed1989

Early experience with percutaneous lateral discectomy.

Seventeen patients were treated by percutaneous lumbar discectomy for a herniated disc and sciatica. The criteria for inclusion in this series included: (1) a protruding disc in the lumbar area causing neural compression; (2) persistent sciatica; (3) failure of conservative treatment; (4) magnetic resonance imaging, computer tomographic, or myelographic confirmation of the protrusion; and (5) chronic low-back pain with definite evidence of a protruding disc at the appropriate level. The only contraindication to the procedure is the presence of an extruded fragment. There were ten male and seven female patients, with an average age of 40 years. The operation was performed under local anesthesia and by the method of Hijikata. Six cases were at L5-S1, nine at L4-L5, four at L3-L4, and one at L2-L3. Fourteen of 16 patients were relieved of their symptoms. One operation was aborted due to the inability to pass the cannula beneath arthritic facet joints. One complication occurred early while using general anesthetic. An L5 nerve root was injured, causing a permanent drop foot. Major possible complications include infection, nerve root injury, and vascular injury. The success rate with an average follow-up period of six and one-half months was 87.5%.

Adult↗
PubMed1987

Comminuted intertrochanteric fractures treated with a Leinbach prosthesis.

A series of 105 Type III and IV comminuted intertrochanteric fractures were treated by the insertion of a Leinbach prosthesis and followed for an average of 8.1 months. Based upon the results, the insertion of a Leinbach prosthesis is recommended for the elderly patient with a comminuted intertrochanteric fracture. Function is restored within a short period of time and allows unrestricted weight-bearing almost immediately. The hospital stay is shortened. The incidence of secondary operations, thrombophlebitis, pulmonary embolism, decubiti, and pneumonia is relatively low.

Aged↗
PubMed1986

Low-dose, slow-increase bromocriptine in patients with progressive Parkinson's disease and complications of levodopa therapy.

We studied the effect of adding low-dose bromocriptine to levodopa/carbidopa (Sinemet) in 26 patients suffering from progressive Parkinson's disease with loss of levodopa effectiveness or levodopa-induced fluctuations. Despite the high incidence of drug intolerance and low response rates, a significant proportion of patients with the wearing-off effect and dystonia improved. Low-dose, slow-increase bromocriptine is warranted as adjunctive therapy in these patient subgroups.

Aged↗
PubMed1980

Hemangiopericytoma of the cervical spine: report of an unusual case.

A hemangiopericytoma of the cervical spine in a 31-year-old woman is possibly the first reported in the orthopedic literature. There is some confusion about the most efficacious treatment. Based on six cases in the medical literature, it would appear that adjunctive radiation, postoperatively, helps to decrease the recurrence rate of the tumor.

Adult↗
PubMed1979

Primary treatment of comminuted intertrochanteric fractures of the hip with a Leinbach prosthesis.

The authors present 43 cases of comminuted intertrochanteric fracture, treated by replacement with a Leinbach prosthesis. The average age of the patient was 81 years, the average time of operation was 70.8 min, and the average blood loss was 502 cc. 88% of the patients were walking within 4--10 days. One deep infection occurred requiring removal of the prosthesis five months later. Based on this experience, the authors recommend consideration of the use of a Leinbach prosthesis in the primary treatment of the elderly patient with a comminuted intertrochanteric fracture of the hip.

Female↗