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Biomedical subjects

M B Shvyrkov

Publications and source records attributed to M B Shvyrkov.

36 records · Page 2Linked to original sources
PubMedDate not supplied

[The dependence of the osteoinductive activity of the bone matrix on the mass and area of the transplant].

White rat experiments have demonstrated that bone matrix osteoinductive activity (the matrix ability to induce ectopic osteogenesis) is in direct proportion with the transplant mass in cases when this mass is within 0 to 0.16% b. m. A higher transplant mass is not associated with elevated osteoinductive activity. When the transplant masses are equal, their osteoinductive activities are in proportion with their sizes. These regularities should be borne in mind when choosing the transplant mass and shape.

Animals↗
PubMedDate not supplied

[Role of the destructive phase of regeneration in reparative osteogenesis].

Experiments were conducted on mongrel male rats to study the dependence of the character of maxillary fracture consolidation on the content of osteo-inducing (01) and osteo-inhibiting (I) proteins in the bone tissue as well as the effect of agents intensifying (parathormone) or reducing (methyluracil) the resorption phase of bone regeneration. It is shown that the ratio of OI and I proteins in the bone tissue determines the healing of the fracture according to the type of uncomplicated or slow consolidation in untreated animals, whereas parathormone administration increases the number of animals with uncomplicated consolidation of the fracture and raises the strength of union of the fragments. Methyluracil fails to produce such on effect. It is suggested that improved regeneration of bone in intensification of the phase of resorption is due to more effective excretion of OI proteins from the injured bone tissue.

Animals↗
PubMedDate not supplied

[The elimination of mandibular defects by an osteoplasty method using local tissues].

Mandibular body defects 0.5 to 4.5 cm long were eliminated in 33 patients. Fracture edges were brought together to meet by means of compression distraction apparatus; when the surfaces were congruent, they were compressed. 10-12 days later distraction was started at a rate of 0.25 mm 4 times a day. Bone and soft tissue defects were replaced in the course of distraction. Soft tissue insufficiency that usually prevents free osteoplasty in this case favors local tissue osteoplasty.

Bone Nails↗
PubMedDate not supplied

[Changes in the osteoinductive activity of the bone matrix in ontogeny].

Correlation between the animal's age, degree of mineralization of its bone tissue and the osteoinductive activity of the bone organic matrix was established in experiments with rats of the same litter at an age of 2, 4, 8, 16 weeks. The osteoinductive activity was estimated by the capacity of matrix to induce ectopic osteogenesis using biochemical methods. Bone mineralization increased and the capacity for osteoinduction decreased roughly 1,5-fold with the age of donor animals. It is suggested that the reduction of osteoinductive potencies is based on the decrease in lability of the bond between the protein osteoinducer and the collagen matrix, as shown by unequal sensitivity of bone matrix of rats of different age to the doubling of the shortest possible time of bone demineralization.

Aging↗