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Biomedical subjects

M Auriol

Publications and source records attributed to M Auriol.

At least 109 records · Page 6Linked to original sources
PubMed1986

[Approach to age determination based on dental morphological criteria obtained in microradiography, stereomicroscopy and scanning electron microscopy].

The determination of the age owing to the morphology of permanent teeth has been done in 14 men and women, using criteria proposed by Gustafson. It was faithful, the difference between age determined by this method and the true age of these patients being never superior to 3 years. The application of scanning electron microscopy allows to improve some of the criteria used for this determination, especially that based upon the dentinal senescence.

Adult↗
PubMed1986

[Tissue lesions in dental displacement].

Following the observation of alveolar, periodontal and dental lesions following dental displacement, the authors performed histological examinations. Lacunae of root resorption were observed in the pressure zones. The ligamentous fibres were less organised and, when strong pressures were exerted, they became parallel to the tooth. Osteoclasts and bone resorption were observed in the alveolar bone. Osteoblasts and bone apposition were observed in areas of stretched ligaments. These tissue reactions were not always reversible; dental displacement should be considered to be a high risk procedure.

Alveolectomy↗
PubMed1986

[Odontogenic myxoma. A histoenzymologic and ultrastructural study. Apropos of 5 cases].

The myxoma of the jaws represent 8% of the odontogenic tumours in our series (324 cases). The 5 cases described here were studied by histoenzymological and electron microscopic methods. The first method demonstrated in the majority of tumoral cells a high level of activity of alkaline phosphatases and ATPases similar to that noted in odontoblasts of the dental pulp. In addition, an acid phosphatase activity was also present in numerous cells but usually at a low intensity. Ultrastructurally, the tumour was composed of 3 main cellular types: young round cells with numerous ribosomes; stellate secretory cells with well-developed granular ergastoplasma and Golgi apparatus; fusiform cells with characteristics of fibroblasts. Some macrophages and myofibroblasts were also present. The intercellular substance was granulofilamentous and in one of our cases calcifications were obvious upon some collagen fibers. All these results seem to corroborate the hypothesis of odontogenic nature of the tumour. Early odontogenic induction induces the transformation of fibroblasts into cells with enzymatic activities similar to those of odontoblasts and the calcification of collagen fibers seen in one of our cases would express an early mineralization.

Esterases↗
PubMed1986

[Basal cell adenoma of the parotid. An ultrastructural study].

The monomorphic basal cell adenoma of parotid gland is a rare tumor of salivary glands. Its diagnosis is difficult with adenoid cystic carcinoma. In the case reported here, a peculiar type named membranous adenoma, the thickness of basement membranes, their penetration inside the epithelial lobules, form true cylinders as in adenoid cystic carcinoma. The histoenzymology and the electron microscopy provide important diagnostic arguments: activity of alkaline phosphatases lower than in cystic adenoid carcinoma; cells of adenoma more differentiated (epidermoid or secretory cells) than those of cystic adenoid carcinoma. The prognosis of the tumor is good, though recurrences may occur.

Acid Phosphatase↗
PubMed1986

[Merkel-cell tumor associated with a spinocelluar epithelioma. Apropos a case report].

One case of Merkel cell carcinoma is reported in a 71 years-old woman. Lately treated by surgical excision (14 years after the occurrence of the tumour), this tumour was already associated with inguinal lymph node metastases. Its evolution was lethal within 3 months after local recurrence, cutaneous and visceral (lung, liver) metastases. This tumour, characteristic histologically and ultrastructurally (secretory granules), was accompanied by an infiltrative epidermoid carcinoma. This association and the presence of cytokeratin in tumoral Merkel cells are arguments for the common origin of keratinocytes and neuroendocrine Merkel cells from a common young epithelial cell.

Aged↗
PubMed1986

[Essential and iatrogenic gingival hyperplasia. Its morphology and significance].

11 specimens were carried out in patients with idiopathic gingival hyperplasia (3 cases), gravidic hyperplasia (1 case), iatrogenic hyperplasia (5 cases after cyclosporin A administrated in patients with cardiac grafts, 2 cases after treatment by Adalat). By optic microscopy, the deep collagen base is thickened, associated sometimes to an inflammatory process. By histoenzymology, the fibroblasts have high activities of their oxidative enzymes and also of the enzymes of protein synthesis. The electron microscopy corroborates the numerous globular fibroblasts with well-developed rough endoplasmic reticulum. These results prove the main role of fibroblasts in these lesions and the etiopathogenesis of this hyperplasia is discussed.

Adolescent↗
PubMed1986

[Angiolymphoid hyperplasia with eosinophilia (Kimura's disease). Apropos a case report with ultrastructural and histoenzymological study].

One case of angiolymphoid hyperplasia with eosinophilia is related in a 30-years old woman. This observations has all the characteristics of the disease: telangiectasic oedema, nodules and infiltrated areas located in the cervico-facial skin and also in the nasal and buccopharyngeal mucosa. Histologically, the proliferation is made of adult or young capillaries surrounded by inflammatory cells. The results of the peculiar morphological methods used here prove the endothelial nature of cells: high enzymatic activities of alkaline phosphatase and ATPases; factor VIII present on the cells; ultrastructural features characteristic of more or less differentiated vessels. Besides their nosologic interest, these methods may be useful for the diagnosis of this disease with the other vascular tumors.

Adult↗
PubMed1986

Ultrastructural study of the lacrimal gland in a case of Sjögren's syndrome.

A 78-year-old woman, affected by a Gougerot-Sjögren's syndrome, had a typical keratoconjunctivitis sicca associated with xerostomia. A biopsy of lacrimal and accessory salivary glands was studied by conventional histological methods. In addition, the lacrimal gland was studied by electron microscopy. The two varieties of gland showed lesions of the same intensity with a similar decrease of lactoferrin and lysozyme. However, the ultrastructural features noted in the lacrimal gland were suggestive of an immunological reaction different from that noted in salivary glands. The attrition of ductal epithelia by lymphocytes was obvious but was never followed by regeneration and ductal ectasia. The massive infiltration of lymphocytes in the lobules and the early sclerosis of gland tissue appeared to be the main factor. Apparently, the sclerosis was not consecutive to the activity of periductal myoepithelial cells but resulted from the activity of fibroblasts in the production of basal membranes and collagen connective tissue.

Aged↗
PubMed1986

[Renal lesions induced by cyclosporin. Apropos of 4 renal biopsies and 22 necropsies of recipients of heart transplant].

The morphological study of kidney in patients without any preexistent renal disease and treated by cyclosporine corroborated the nephrotoxicity of this immunosuppressive drug. 4 biopsies (in 2 patients with Behçet's disease, in 1 recipient of allogenic medullary graft and 1 recipient of heart transplant) were performed for acute renal failure observed in a variable time after the beginning of treatment (7th day to 14 months). In two cases, they demonstrated obvious vascular lesions (arteriolar or glomerular thrombosis, fibrinoïd necrosis) and they detected constantly changes of proximal convoluted tubules (epithelial vacuolization or necrosis, calcifications). In addition, the ultrastructural study performed in all cases showed a striking increase of lysosomes and some giant mitochondria. The 8 autopsies of recipients with heart transplants treated by cyclosporine for more than 1 month corroborated also these renal changes which were always correlated with biological perturbations of the renal function (increase of level of serum creatinine). Besides the proximal convoluted tubular lesions (vacuolization, necrosis and calcifications), an obvious increase of the interstitial tissue proportional to the long time of treatment was always detected.

Adolescent↗
PubMed1986

[Basal cell adenoma of the parotid. Apropos of a case with an ultrastructural study].

A case of Basal cell adenoma occurring in a 42 year-old woman is reported. Histological examination showed trabeculae of basaloid cells with thick Basal Membrane at the periphery. By Electron Microscopy most of the cells displayed numerous desmosomes and intracytoplasmic tonofilaments indicating epidermoid differentiation. In addition some glandular cells were observed. No myoepithelial cell were present. Electron Microscopy may be useful to differentiate basal cell adenoma from Adenoid cystic carcinoma which is made up of a majority of poorly differentiated cells.

Adenoma↗
PubMed1985

Human cardiac transplants. Diagnosis of rejection by endomyocardial biopsy. Causes of death (about 30 autopsies).

1,000 endomyocardial biopsies performed in 110 patients treated by cardiac graft were reviewed. These biopsies permitted early detection of acute rejection after cyclosporin treatment and a good appreciation of its intensity. By this method, almost all rejection episodes were resolved after adequate treatment. Chronic rejection was diagnosed by arteriography used in vivo or in cardiac transplants removed by surgery or necropsy. Rejection provoked an obliterative fibrous endarteritis often complicated by atherosclerosis and its ischaemic consequences. 34 autopsies were performed in patients dead at a variable time after cardiac or cardio-pulmonary transplantation. In early death (14 cases), graft failure and systemic disorders were observed. Acute and chronic rejection was noted less frequently (9 cases). Systemic infections (10 cases) occurred either early (post-surgical complications) or late (bacterial, fungal and parasitic lesions). In one case, death was due to a contemporaneous bladder carcinoma. The complications of cyclosporin treatment are briefly discussed.

Acute Disease↗
PubMed1985

Histoenzymological features of epithelial cells in lesions of oral mucosa in cysts and ameloblastomas of jaws.

A histoenzymological study was carried out on 41 tissue specimens removed at biopsy and for surgical operations of the following lesions: benign hyperkeratosis, lichen planus, severe epithelial dysplasia, carcinoma in situ, epidermoid carcinoma, radicular cyst, odontogenic keratocyst and ameloblastoma. The purpose of this study was to study some possibly significant variations in levels of activities of oxidative enzymes, diaphorases, acid phosphatases and Naphthol esterases in such lesions (normal oral mucosa and epidermis serving as controls). In the lesions of the oral mucosa, these histoenzymological variations were not sufficiently characteristic to contribute to histological diagnosis. In lichen planus, some vacuolated or necrotic basal cells lacked enzyme activities, whereas in the upper layers, enzyme activities were irregularly present. Benign hyperkeratosis showed enzymatic activities similar to those of the normal epidermis, namely high oxidative activities particularly prominent in basal cells and in granular layer, and esterase activity beneath the keratinized layer. In severe epithelial dysplasia, carcinoma in situ and epidermoid carcinoma, numerous variations of activities of oxidative enzymes, esterases and acid phosphatase were seen from one cell to the other. In cystic diseases of jaws, enzymatic activities were equally nonspecific in the epithelial lining of the radicular cyst and the odontogenic keratocyst (activities similar to those of normal oral epithelium and epidermis, respectively). But in common ameloblastoma, there was diffuse uniformly low oxidative enzymatic activities in the epithelium and high widespread activity of alkaline phosphatase in the stroma. The latter may be useful in differentiating the cystic acanthomatous variety of ameloblastoma from odontogenic keratocysts of the jaws.

Ameloblastoma↗
PubMed1985

[Classification of benign tumors and cysts of the jaws].

On the basis of 324 cases of maxillary tumours, the authors review the classification of these neoplasms. The most frequent tumours are benign epithelial odontogenic tumours, which represent 55% of all tumours. The most common of these tumours is the ameloblastoma, followed by the odontomas. Most of the tumours of non-dental origin are benign (72% of this group). Amongst the malignant tumours, osteosarcomas are much more common than chondrosarcomas. The authors also discuss the various types of cyst and their respective relative frequency.

Ameloblastoma↗
PubMed1985

[Mandibular mucoepidermoid tumor].

One case of mandibular mucoepidermoid tumour was observed in a 57 years old man. A progressive swelling of the mandible was shown with an osteolytic feature on roentgenograms. It was treated by hemimandibulectomy. Grossly, the neoplasm was partly cystic. Histologically, it was mainly composed of intermediate clear cells. Its ultrastructure was quite similar to that of mucoepidermoid tumours in other sites. Heterotopic salivary lobules, though lacking in our case, seem to play the major role in the genesis of these tumours.

Carcinoma↗