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Biomedical subjects

M Asakawa

Publications and source records attributed to M Asakawa.

At least 163 records · Page 9Linked to original sources
PubMed1985

Mercuric reductase enzymes from Streptomyces species and group B Streptococcus.

Mercury volatilization (Hg2+ reductase) activity has been found with Hg2+-resistant isolates of three Streptomyces species and with three Hg2+-resistant strains of group B Streptococcus from clinical sources in Japan. Hg2+ reductase activities in crude cell extracts showed the temperature sensitivity, the requirement for an added thiol compound and the characteristic dependence on NAD(P)H cofactors of similar enzymes isolated from other bacteria.

Drug Resistance, Microbial↗
PubMed1984

Benzethonium chloride resistance in Pseudomonas aeruginosa isolated from clinical lesions.

The benzethonium chloride resistance of 341 strains of Pseudomonas aeruginosa isolated from Jikei University Hospital was determined. The distribution pattern of the susceptibility to benzethonium chloride clearly revealed two peaks, and the resistance was differentiated by 1000 micrograms/ml (0.1%) of benzethonium chloride. The frequency of resistance to benzethonium chloride was 51.6%. Furthermore, the frequencies of resistance to SM, TC, CP, KM, GM, PIP, Hg, Cd, As and chlorhexidine were 42.5, 15.8, 41.3, 29.6, 14.0, 8.2, 88.3, 97.9, 97.1, and 74.5%, respectively.

Anti-Bacterial Agents↗
PubMed1984

Survey of resistance to metals and volatilization activity of Hg-resistant R plasmids in Citrobacter isolated from clinical lesions in Japan.

Clinical isolates of Citrobacter (277 strains) were studied for the resistance to four metals and four drugs. The distribution patterns of their susceptibility to Hg, Cd and As clearly revealed two peaks, but only a single peak of resistance to Pb. The frequencies of resistance to Hg, Cd, As, SM, TC, CP and KM were 31.8, 94.2, 57.8, 51.3, 44.8, 35.7 and 28.9%, respectively. And we selected 88 mercury resistant strains, and they were tested for their ability to transfer the resistance to the mercury and drug sensitive recipients of E. coli K12-ML1410-Nx and E. coli JE17-Rif. Among 88 strains of Hg resistant Citrobacter, 80 R plasmids with Hg resistance could be demonstrated. It should be noted that transferable R plasmids with Hg resistance were demonstrated in 91% of the Hg-resistant isolates. Furthermore, we tested the volatilization of mercury by strains containing these mercury resistance plasmids, by using radioactive 203Hg2+. All of these isolates of Citrobacter have volatilization activity of Hg2+. Also, all of these volatilization activity is inducible.

Anti-Bacterial Agents↗
PubMed1983

A case of bronchioloalveolar carcinoma. Ultrastructural and lipid-biochemical studies.

A case of bronchioloalveolar carcinoma was studied electron microscopically and lipid biochemically. Electron microscopic examination revealed that the tumor was composed of three different types of cells, undifferentiated cells, cells possessing lamellar inclusion bodies within the cytoplasm, and cells containing mucus droplets. The characteristic findings in the phospholipid profiles of this case of bronchioloalveolar carcinoma were a high content of saturated classes of phosphatidylcholine, especially of the dipalmitoyl type, and the occurrence of appreciable amounts of phosphatidylglycerol. These observations indicate that some of the tumor cells examined in this study had the characteristic feature of alveolar type II cell differentiation which is responsible for production of pulmonary surface-active materials. The value of phospholipid analysis in assessing such tumors is emphasized.

Adenocarcinoma↗
PubMed1983

[A case of Buschke-Loewenstein tumor].

A 67-year-old man with a tumor resembling carcinoma of the penis was seen at our Department. The tumor appeared clinically to be malignant and partial amputation of the penis was therefore performed. But biopsy specimens from parts of the mass were benign and histological examination revealed Buschke-Loewenstein tumor.

Aged↗
PubMed1981

Isolation of two endo-beta-N-acetylglucosaminidases from fig latex.

Two endo-beta-N-acetylglucosaminidases (mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase, EC 3.2.1.96) (type F-I and type F-II) have been isolated from fig latex. At pH 7.0, type F-1 was retained by the DEAE-Sephadex A-50 column, whereas type F-II was not adsorbed by the column. The optimum pH of type F-I was found to be pH 5.9 and type F-II, pH 5.4. Type F-I enzyme hydrolyzes the tri-mannosyl derivatives di-N-acetylglucosaminylasparagine faster than the penta- or hexa-mannosyl compounds. Type F-II hydrolyzes the penta- and hexa-mannosyl derivatives, but not the tri-mannosyl compound.

Acetylglucosaminidase↗
PubMed1981

Dirofilaria immitis infection in man: report of a case of the infection in heart and inferior vena cava from Japan.

Two slender nematodes were incidentally found at autopsy in the heart and inferior vena cava of a 36-year-old Japanese man who died of liver cirrhosis. The parasite from the heart measured 29.5 cm by 0.87 mm, and that from the inferior vena cava 26.5 cm by 0.85 mm. The worms were identified as non-gravid adult female Dirofilaria immitis. This is the fourth case of infection with D. immitis in the heart and large vessels.

Adult↗
PubMed1981

[Clinical studies of cefoxitin for the treatment of chronic respiratory tract infections (author's transl)].

1. Serum and sputum concentrations of cefoxitin were measured at fixed intervals following a one hour drip infusion of 2 g to a total of three patients with chronic respiratory tract diseases. The peak levels in serum were found to be 142.1-273.6 microgram/ml at the end of the infusion and those in sputum were found to be 0.92-2.30 microgram/ml at 2 to 4 hours after initiation of the infusion. 2. Cefoxitin was administered to a total of five patients with chronic respiratory tract infections who had failed to respond to the previous treatments with conventional antibiotics. The results were that in one case the therapeutic effect was judged as excellent, in three cases as good, and in one case it was difficult to evaluate. In all cases, there was no significant abnormality indicative of side effects regarding clinical symptoms and laboratory tests of renal and hepatic functions. In a view of the findings stated above, it is considered that cefoxitin is a new antibiotic which can be used for the treatment of chronic respiratory tract infections.

Aged↗