[Changes in nasal mucociliary clearance in normal subject and in patients with various nasal pathologies].
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Biomedical subjects
Publications and source records attributed to M Armengot.
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We have operated eight patients with nasal obstruction secondary to internal valvular incompetence. In three of them an alar collapse were associated. Diagnosis was made by anamnesis and clinical exploration. Open rhinoplasty approach was employed. Surgical technique was the transposition of lateral over alar cartilage. In the three patients with alar collapse, a fixation graft of septal cartilage were added to the previous technique. Nasal obstruction and valvular incompetence missapeared in all the patients.
Transsphenoidal approach is the most commonly employed surgical technique for the resection of pituitary tumors. We present our experience in the transnasal-transsphenoidal approach in 30 patients undergoing pituitary surgery from 1998 to 2002. Ten patients underwent surgery via a sublabial-transeptal-transsphenoidal approach, 15 patients via a transeptal-transsphenoidal approach and 5 patients via a pure endoscopic transnasal-transsphenoidal. The pathological study showed 29 pituitary adenomas and 1 Rathe's cleft cyst. We conclude that the pure endoscopic transnasal-transsphenoidal approach guided by a navigator-system is safest and more effective approach. We reserved the transeptal-transsphenoidal approach for cases with obstructive septal deflection and poor pneumatized sphenoid sinuses. We do not recommend the use of the sublabial-trans-sphenoidal approach.
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We studied histophatological parameters and DNA content in 27 supraglottic and 37 glottic T-1 squamous cell carcinoma of the larynx. The DNA content was determined by the Hedley method in paraffin-embedded sections of formalin-fixed blocks in an EPICS Profile flow cytometer. We studied 14 histopathological parameters and only 3 were statistically different in both groups of tumors: Differentiation, infiltrative degree and mitoses. There weren't statistical differences in DNA content (DNA index and proliferation index).
DNA content of tumor cells determined by flow cytometry has been correlated to biologic behavior and to prognosis for many solid tumors, but insufficient data has been accumulated for squamous cell carcinoma of the larynx. In order to know the predictive value of this parameter in the prognosis of T-1 vocal cord squamous cell carcinoma, we have studied 27 patients submitted to cordectomy. The patients outcome was followed for a minimum of five years or until death, DNA content was determined by Hedley method in paraffin-embedded sections of formalin-fixed blocks in an EPICS Profile flow cytometer. 24 of these tumors were diploid (89%) and 3 aneuploid (11%). We didn't find statistical correlation between ploidy and survival, local failure or someone of the pathological parameters.
Transcranial magnetic stimulation method permits the study of the facial nerve in all its aspects (motor cortex-alpha moto-neurone-facial muscle) in an non invasive and painless way. We studied 12 patients using two levels of stimuli, the first was at an occipital level and the second at the primary motor cortex in the frontal lobe. We compared the results of this technique with those obtained by electric stimulation of the nerve.
Twenty vocal cords were studied. The used animals were rabbits. Beta-blockers and beta-stimulants were perfused by the jugular vein. Variations in endogenous peroxidase were observed in electron microscopy. The activity of endogenous peroxidase can be used according to our results as tracer of the autonomic innervation of the vocal cord.
The authors present one case of elongated Styloid process which surgeons was undertaken due to intense symptomatology. Oropharyngeal approach was used and showed to be the election way for resection.
Osseus hemangioma is a rare tumor. Its concept and a etiology are not well established. We preset a review and a case of this tumor located in the upper maxilla. Clinical, of this exploration and pathology are studied in this paper. Antigen in factor VIII has been observed. Considerations on different diagnosis are made.
Nasal mucociliary function has been studied in 21 children suffering recurrent airway infections. Previously, cystic fibrosis, immune deficits and allergy were discharged. 38 per cent of these patients had alterations in the mucociliary transport and in this group, it was observed an increase of bronchiectasis, permanent rhinorrhea and serous otitis media.
A clinical and morphological study about neuroblastoma with olfactory differentiation are made. This study includes: TAC, vanimil mandelic acid urine determination, optic microscope, immunohistochemical technique, neuropeptidal, in situ hybridization, DNA analysis by flow cytometry and electronic microscope.
We have studied the tubaric mucociliar transport time using a saccharin solution in: 1. A control group with normal eustachian tubes being the transport time smaller than 20 minutes. 2. A group of 30 ears with chronic middle ear disease with a central perforation; 23% of them had a transport time within normal range, in 46% the transport time was prolonged and in 30% transport was absent.
We have study the nasal mucociliary clearance in 150 normal persons. Four methods have been used: vegetable charcoal powder, saccharin, seroalbumine-Tc99m and pertechnetate-Tc99m. The time and speed of mucociliary nasal transport are related to the solubility of the tracer. The insoluble substances have a faster transport. The mean transport time for charcoal powder is 8.3 +/- 2.6 min. and for the saccharin is 17.4 +/- 5.5 min. The mean velocity for seroalbumine is 8 +/- 1.8 mm/min. and for the pertechnetate is 5 +/- 0.2 mm/min.
The increased frequency of Pseudomonas aeruginosa in suppurative chronic otitis media makes this bacillus interesting. We consider the biological pathogenic and biochemical mechanisms, as well as some aspects of the interaction between PA and antibiotic therapy.
We show our experience during four years, with a new technique used in the management of bilateral vocal cord paralysis. We expose clearly the surgical technique, and the obtained results. We have done 15 cordopexy techniques to 10 patients with bilateral vocal cord paralysis, from different etiology, being the thyroid gland surgery, the most frequent.
In this paper we present a follow up of 24 patients that underwent total laryngectomy with Herrmann's technique of phonatory voice prosthesis. We discuss the complications and the facts that provoqued the removal of the prosthesis.
Ten newborn children and one diagnosed of Kartagener syndrome where studied by the Tc99m-labelled human serum albumin technique. In our results, this technique probed to be extremely useful and showed stasis of mucous in the pathologic case.