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Biomedical subjects

M Anthony

Publications and source records attributed to M Anthony.

At least 73 records · Page 4Linked to original sources
PubMed1977

Sodium valproate and clonazepam in the treatment of intractable epilepsy.

Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months. Each agent was used sequentially in an overlapping group of 32 patients. Both agents have proven effective in the control of petit mal absences and myoclonic jerks, although some patients responded to one and not to the other. Clonazepam has given better results than valproate in temporal lobe and other partial (focal) epilepsies, while valproate has given better results in grand mal seizures and atonic attacks. Both preparations were more effective in patients with spike and wave paroxysms in their EEG recordings, the correlation being more conspicuous with valproate. Both medications appear to be safe and useful additions to anticonvulsant therapy.

Adolescent↗
PubMed1977

Plasma sodium valproate levels and clinical response in epilepsy.

Serial plasma levels of sodium valproate were estimated in 12 epileptic patients and 10 normal subjects after a single dose of the drug, whilst random estimations were performed in another group of 32 patients already stabilised on sodium valproate. The tentative conclusions arrived at by this study were: 1) In the majority of patients and normal subjects peak plasma levels were reached by the end of the first or second hour. 2) The majority of clinically controlled subjects showed a plasma level above 40microgram/ml. 3) Similar doses of sodium valproate (mg/kg) produced higher plasma levels in normal subjects than in the epileptic patients. Whether this is an effect of other anticonvulsants the patients were taking at the same time is a matter for conjecture. 4) Dosage and plasma levels did not appear to show a close correlation. 5) Random estimation of plasma levels are of little value for monitoring therapeutic efficacy, unless timed in relation to the dose, for reasons already mentioned above.

Anticonvulsants↗
PubMed1976

Zinc nutrition of preschool children in the Denver Head Start program.

Low income diets provide relatively little zinc. This study was designed to evaluate the zinc nutritional states of 74 low income preschool children enrolled in the Denver Head Start Program. Zinc is necessary for normal growth, hence children were selected on the bases of low height percentiles. The mean (+/- SE) hair zinc concentration was 87.0 +/- 5.9 mug/g, and the mean plasma zinc concentration was 74.5 +/- 1.5 mug/100 ml. These levels were both lower (P is less than 0.005) than those of middle income children of similar age. Sixty-eight percent of the study group had a hair zinc concentration less than 70 mug/g and/or a plasma zinc concentration less than 68 mug/100 ml. These results indicate that inadequate zinc nutrition may be common among preschool children with low growth percentiles from low income families.

Body Height↗
PubMed1976

A unique case of derangement of vitamin B12 metabolism.

The case is described of a child, age 6 1/2 years, with retarded mental development, mild neurological signs and abnormal metabolism of sulphur-containing amino acids and methylmalonate, due to an inborn error in the formation of vitamin B12 coenzymes. The patient was treated for almost three years with hydroxycobalamin, folic acid, pyridoxine and choline. Though physical growth was normal, she continued to demonstrate a moderate degree of mental retardation. A brother of the patient died at the age of 5 years, probably of a similar, but undiagnosed, disorder. As far as we are aware there are only four other reported cases similar to the case described here. Two of these patients died and in other other two the defect was so mild that no treatment was necessary and who, in fact, showed appreciable improvement during the follow-up period, which to date amounts to 3 years and 3 months. For reasons detailed in the discussion, it is suggested that the diagnosis of homocystinuria is not complete until studies of folate and vitamin B12 metabolism are undertaken at the same time, so as to identify the metabolic defect(s) responsible for the condition.

Child, Preschool↗
PubMed1975

A study of the Indian valve for ventriculo-atrial shunts in the treatment of hydrocephalus.

Because of the high costs of importing commercially-available shunts, a hand-made ventriculo-atrial shunt was devised in India for the treatment of hydrocephalus. Modifications have been made to the original design and these shunts are now being produced commercially at a fraction of the cost of other available shunts. Hydrodynamic testing indicates that they compare favourably with the other shunts at present in use.

Cerebrospinal Fluid Shunts↗
PubMed1975

Amine turnover in migraine.

Excretion of the vaso-active amines tyramine, serotonin, noradrenaline, adrenaline and histamine and blood levels of serotonin, noradrenaline, adrenaline and histamine, were estimated in 10 patients before, during and after an attack of migraine. During the headache process there was a statistically significant fall in the excretion of tyramine and a similarly significant rise in the excretion of serotonin. Excretion of the other 3 amines showed no significant fluctuation during the various phases of the migraine attack. Blood levels of serotonin were significantly lower during headache than during freedom from headach. whilst whole blood histamine was significantly higher only during the postheadach phase. The meaning of the latter observation is not obvious. The above results are discussed in the light of recent reports that tyramine is the substance responsible for headache attacks in patients who have a history of dietary migraine. Reasons are offered as to why this is unlikely to be the case.

Biogenic Amines↗
PubMed1975

Sodium valproate in the management of intractable epilepsy: comparison with clonazepam.

Sodium valproate 400 mg.-1800 mg. daily has been used for 1-4 months in the management of 35 patients with intractable epilepsy. This preliminary report indicates that the agent is a useful addition to anti-convulsant therapy with beneficial effect to the majority of patients with gran mal, petit mal, nyoclonus and akinetic attacks. Temporal lobe epilepsy and other focal cortical seizures responded less well. There were some minor gastrointestinal and neurological side-effects which subsided with time or the reduction of dosage. The transition period while other anticonvulsants were being withdrawn was accompanied by grand mal seizures in 6 patients. It appears that sodium valproate requires 7-10 days to becoms fully active and that other anticonvulsants should be withdrawn only after the patient is established on a maintenance dosage. Comparison with clonazepam suggests that the latter is more effective in the control of petit mal and temporal lobe epilepsy but has more persistent sedative effects. Most patients transferred from other anticonvulsants to sodium valproate felt more alert and able to concentrate better.

Adolescent↗
PubMed1971

Cluster headache.

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Headache↗