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Biomedical subjects

M Anderson

Publications and source records attributed to M Anderson.

At least 415 records · Page 23Linked to original sources
PubMed1982

Intracranial tuberculomas: correlation of computerized tomography with clinico-pathological findings.

Ten patients with intracranial tuberculomas, seen between 1976 and 1980, are described. Four Indian immigrants presented with features of space-occupation and responded well to supervised adequate combined anti-tuberculous chemotherapy. Six patients, four of whom were English, developed tuberculomas in the course of tuberculous meningitis; three of these six patients died, highlighting the dangers of this complication if infection is not promptly and adequately dealt with at presentation. The value of computerized tomography in the diagnosis and management of such patients is emphasized, and the persistence of intracranial tuberculous infection in Britain is stressed.

Adolescent↗
PubMed1981

Inhibition of lipolysis in bovine milk by proteose peptone.

The ability of total milk proteose peptone and individual proteose peptone components to inhibit lipolysis in milk was examined. Proteose peptone (1.5 mg/ml) when added to milk inhibited lipolysis, and component 3 was a more effective inhibitor than component 5 or component 8-fast. Inhibition by proteose peptone also occurred when the milk was treated with between 2 and 20% v/v bovine blood serum or with 5 micrograms/ml heparin. In vitro activity of milk lipoprotein lipase and its stability were not affected by proteose peptone. It was concluded that proteose peptone does not interact with lipase or its activator and that the mechanism of inhibition involves the substrate.

Animals↗
PubMed1981

Cytotoxic effects of dental cements on two cell culture systems.

Four dental cements and one bis-GMA composite were tested in cultures of human periodontal ligament fibroblasts and mouse 3T3 fibroblasts. It was found that these cell types reacted to the cements with different intensities, and that there were differences in evaluation by phase contrast microscopy and succinic dehydrogenase histochemistry.

Animals↗
PubMed1980

Conjugal disharmony: a hitherto unrecognised cause of strokes.

Two women of reproductive age suffered strokes. Neither was taking oral contraceptives, and investigations showed no other causal factors. The radiological findings were characteristic of traumatic internal carotid artery occlusion, but neither patient gave a history of trauma. Only after further inquiry into the patients' social circumstances did it emerge that each had survived an attempt at strangulation by her husband. Such a cause of stroke in young women should be considered when other causes of carotid artery occlusion cannot be identified.

Adult↗
PubMed1980

Ultrastructure of the antennal sensilla of aphids. II. Trichoid, chordotonal and campaniform sensilla.

An electron microscopical study of aphid antennal sensilla has revealed two types of trichoid sensilla. Type I, innervated by a single neuron is mechanoreceptive; type II, innervated by three to five neurons is both mechanoreceptive and chemoreceptive with possibly a third function. Johnston's organ in the pedicel comprises a peripheral ring of scolopidia inserted into the joint with the flagellum; two non-peripheral groups of scolopidia lie in the lumen with attachment points in the wall of the third segment. The fine structure of a campaniform sensillum on the pedicel is described together with two homologous and previously unknown sense organs at the joint between the fifth and sixth antennal segments. An unusually placed scolopidium in the lumen of the sixth segment has also been found. The function of this scolopidium is unknown but Johnston's organ, the campaniform sensillum and joint receptors are suggested to act as antennal proprioceptors.

Animals↗
PubMed1980

Gliomatous transformation and demyelinating diseases.

The clinical and pathological details are described of three patients with demyelinating diseases associated with a glioma, the effects of which proved fatal. The findings suggest that the tumours developed from neoplastic transformation of glia in areas of established demyelination.

Brain↗
PubMed1980

Radiation-induced large intracranial vessel occlusive vasculopathy.

Two patients who developed large intracranial vessel occlusion after standard radiation therapy for brain tumor are described. This form of vascular occlusion is usually seen in patients who have previously been treated by radiotherapy for intracranial tumor who then develop a relatively acute change in neurologic status. Histology of the lesion mimics accelerated focal arteriosclerosis. The clinical and radiographic manifestations of one case were highly atypical. The vasculopathy became evident shortly after termination of radiation therapy for a fourth ventricular ependymoma, and the angiographic picture stimulated a diffuse arteritis. The second patient was more typical, with clinical symptoms developing 12 years after radiation therapy for an oligodendroglioma. Occlusion of a proximal vessel that had been included in the radiation port was demonstrated radiographically and confirmed by pathologic examination. The clinical, angiographic, and histologic features of these two cases are discussed and previously reported cases are reviewed.

Adult↗
PubMed1980

Primary nursing in an organizational context.

This article analyzes primary nursing critically and comprehensively. Synthesizing past and present data, the authors suggest a new definition for primary nursing that takes the organizational context into consideration. They illustrate how organizations influence the effectiveness of primary nursing care. The documented information presented here will save nursing administrators hours of reading and analyzing, and will help them make informed decisions about primary nursing.

Humans↗
PubMed1979

Aliphatic ketones are acetylcholinesterase inhibitors but not transition state analogs.

A number of C4--C9 aliphatic ketones are acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) inhibitors, with Ki values in the 0.7--5 mM range. Comparison to analogous substrates would suggest that these ketones are transition state analogs; e.g. 2-pentanone binds to the enzyme approx. 550 times more tightly than ethylacetate. However, a number of other criteria contradict this conclusions: (1) the binding is insensitive to ketone structure: isomeric ketones, cycloalkanones, and sterically hindered ketones have similar inhibitory potencies. (2) Analogous alcohols are also good inhibitors even though they cannot form hemiketals with the enzyme. (3) Representative ketones are relatively ineffective at blocking inactivation of the enzyme by methylsulfonyl fluoride, indicating that ketones do not bind principally at the hydrolytic site. (4) A competition experiment shows that binding of tetramethylammonium chloride excludes binding of 2-pentanone, suggesting that ketones bind to the anionic rather than the hydrolytic site. Thus, observation of tight binding relative to a substrate is not a sufficient criterion to establish that an inhibitor is a transition state analog.

Animals↗
PubMed1979

Ultrastructure of the antennal sensilla of aphids. I. Coeloconic and placoid sensilla.

An electron microscopical study was made of the coeloconic and placoid sensilla on the antennae of the aphids Aphis pomi, Macrosiphum euphorbiae, Nasonovia ribis-nigri, and Pemphigus bursarius. Scanning electron microscopy revealed some variation in morphology which may be functionally important but is more likely to reflect the evolution of these species. The placoid sensilla were shown by tranwo or three neurons is surrounded by two ensheathing cells. The ciliary regions of the dendrites pass through a vacuole into a cavity between an outer and an inner cuticle where they may be connected to the dendritic branches although such connections were no seen. Small pores (8 nm diameter) partially penetrate the cuticle implying that these sensilla have an olfactory function. They are suggested to be important in host selection by alate aphids. The coeloconic sensilla are poreless pegs with nonsensory cuticular projections at their tips. The distal portions of their dendrites contain densely packed microtubules and the cellular arrangement of the sensila is similar to that of the placoid sensilla. It is suggest that they may function as thermoreceptors.

Animals↗
PubMed1979

Ultrastructural evidence for disuse atrophy in insect skeletal muscle.

The changes which occur in the ultrastruct of the mesothoracic retractor unguis muscle of the cockroach Periplaneta americana as a result of disuse are described. Breakdown of myofibrils, sarcoplasmic reticulum, and mitochondria are all marked, this degeneration only being apparent 9 weeks after the operation.

Animals↗