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Biomedical subjects

M Altini

Publications and source records attributed to M Altini.

At least 55 records · Page 3Linked to original sources
PubMed1986

Plexiform granular cell odontogenic tumor.

Two odontogenic tumors characterized by a previously undescribed histologic appearance are reported. Both lesions consisted of interlacing strands of odontogenic epithelium, with each strand being two cell layers thick. The cells were large and polyhedral in shape, with a granular eosinophilic cytoplasm. The nuclei were arranged "back to back" away from the basement membrane. One of the lesions seems to have originated, at least in part, from the basal layer of the oral epithelium. There is some evidence to suggest that these lesions may represent previously undescribed histologic variants of the ameloblastoma. However, the possibility that they represent a new entity cannot be excluded. For the time being the term plexiform granular cell odontogenic tumor is suggested.

Aged↗
PubMed1986

Oral angiolymphoid hyperplasia with eosinophilia.

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an unusual and controversial lesion that occurs primarily in the head and neck area; oral involvement is rare. A case involving the labial mucosa, in which immunoglobulin deposits were found in association with a damaged centrally located artery, is described. The clinical and pathologic concepts presented in the literature are discussed. Suggestions that these lesions should be reclassified as epithelioid or histiocytoid hemangiomas may not apply to all of the cases that are acceptable as ALHE by current criteria. Different entities, which include vascular neoplasms, Kimura's disease, and possibly other reactive conditions, may be encompassed in the Western literature as ALHE. Involvement of a small artery and occasionally a vein, often with evidence of vascular damage, was reported in 24% of the cases of ALHE that were reviewed. Single nonrecurrent lesions were seldom found in association with blood eosinophilia, although in the absence of eosinophilia, single and multiple or current lesions occurred in 60% and 40% of the cases, respectively.

Adult↗
PubMed1986

Botryomycosis of the oral regions.

Botryomycosis is an unusual bacterial infection capable of producing chronic granulomatous inflammation and characterised by the production of distinctive grains formed by the interaction of the infective bacteria with the host tissues. The occurrence of this infection in a healthy individual generally results in locally destructive lesions which can clinically mimic a sarcoma. A case is reported involving the oral regions of a healthy adult male which illustrated these features and a discussion is presented of the diagnostic features of this condition.

Adult↗
PubMed1986

Granular cell reaction to surgical glove powder.

The histopathologic features characteristic of the inflammatory response associated with starch powder used as a lubricant for surgical gloves were investigated by implanting starch granules into 3 separate sites on the right side of 8 male Wistar rats. On the opposite side, a sham-operated site and sites implanted with talc were used as controls. Two rats were killed at 1, 2, 3 & 4-week intervals and tissue from the implanted sites was assessed for distinctive features. It was found that a consistent feature of the starch-implanted sites was the presence of large histiocytes containing prominent PAS-positive, diastase-resistant inclusions. These cells were not found in the control sites and, thus, were considered characteristic of starch contamination in tissue, even in the absence of identifiable starch granules. A possible clinical case of reaction to starch, identified retrospectively, using these results is discussed.

Animals↗
PubMed1985

Ameloblastic sarcoma of the mandible.

Malignant ameloblastic odontogenic tumors have traditionally been classified as either ameloblastic fibrosarcomas, dentinosarcomas or odontosarcomas. This separation is based on the presence of either dentine or dentine and enamel in some lesions. To date, 28 cases of ameloblastic fibrosarcoma, one case of ameloblastic dentinosarcoma, and seven cases of ameloblastic odontosarcoma have been reported in the literature. An additional case of ameloblastic dentinosarcoma is reported in this paper together with a critical review of the clinicopathologic features of previously reported cases of malignant ameloblastic neoplasms. The presence of dental matrix material is not specific and is found in a wide variety of odontogenic tumors in variable amounts. This study supports the concept that the presence of dental matrix material does not alter the basic biologic characteristics of these neoplasms. Accordingly, to simplify a confusing nomenclature, we suggest that malignant tumors of this type be referred to collectively as ameloblastic sarcomas.

Adult↗
PubMed1985

Age-specific and age-standardised incidence rates for intraoral squamous cell carcinoma in blacks on the Witwatersrand, South Africa.

All new cases of intraoral squamous cell carcinoma which occurred in Blacks resident on the Witwatersrand during the 10-yr period 1971-80 were traced by examining the records of all the hospital pathology departments in this area. The population at risk at the mid-point of the study (1975) was calculated from the National Population Censuses of 1970 and 1980, and consisted of 1125960 men and 880269 women. Age-specific incidence rates and age-standardised incidence rates were calculated for each intraoral site for men and women. In the latter calculation a standard World population was used. All rates are expressed as average number of cases per 100000 population per annum. The age-specific incidence rates and age-standardised incidence rates (in brackets) for men and women respectively are: tongue, 1.43 and 0.26 (2.69 and 0.41); gingiva and alveolar ridge, 0.04 and 0.01 (0.07 and 0.01); floor of mouth, 0.87 and 0.22 (1.64 and 0.38); buccal mucosa, 0.05 and 0.04 (0.13 and 0.05); hard and soft palate, 0.34 and 0.05 (0.63 and 0.08). There appears to have been an increase in the incidence of intraoral cancer in Black South Africans since the first survey in 1953-55, which can probably be ascribed to the urbanization process. In Europe, North America and in other population groups in South Africa, the palate is least frequently affected. In contrast, in Black South Africans lesions of the palate are much more common, being less frequent only than tongue and floor of mouth lesions.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1985

A critical evaluation of epithelial dysplasia in oral mucosal lesions using the Smith-Pindborg method of standardization.

Standardization is one of the greatest problems in assessing epithelial dysplasia, as is establishing the relative importance of different clinical and dysplastic features. In this study, 214 cases characterized histologically by varying degrees of epithelial dysplasia, were analyzed for various clinical features: and representative sections were assessed histologically and graded according to the Smith-Pindborg standardized scoring system. Data were analyzed by computer. Seven cases with scores of less than 10 were excluded as not dysplastic. There were 85 cases (41%) with scores of 11-25 which were regarded as mild dysplasia; 60 (29%) with scores of 26-45 were regarded as moderate dysplasia; and 62 (30%) with scores of more than 45 which were reported as severe dysplasia. Peak frequency was in the 6th decade and the severe dysplasias were most frequent in the 8th decade. The M:F was 2:1. Tongue (58 cases), lower lip (36), floor of mouth (32) and cheeks (26) were sites most commonly involved. Of 107 cases, 93 were described as homogeneous leukoplakia, 11 as speckled leukoplakia and 3 as erythroplakia. The distribution of mild, moderate and severe dysplasias did not differ significantly by age, sex or race. Half of all cases involving floor of mouth and oropharynx were severely dysplastic, whereas most lesions occurring in cheek and alveolar mucosa/gingiva were mildly dysplastic; but differences were not significantly different. Severe grades of each dysplastic feature, as might be expected, occurred in lesions classified finally as 'severe dysplasia'.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

Multiple mucous retention cysts of the oral mucosa.

While mucoceles of the oral mucosa are relatively common, multiple mucous retention cysts have not previously been reported. In this article two such cases, in which numerous minor salivary gland ducts had dilated to the point of cyst formation, are described. The number of individual cysts exceeded 100 in each case. Since it is clear that these cysts formed as a result of dilatation of salivary ducts, it would seem that either the ducts were blocked by altered secretion or there was an acquired or congenital weakness in their structure.

Aged↗
PubMed1982

Prediction of aggressive behavior in basal cell carcinoma.

In this study, a series of aggressively behaving basal cell carcinomas has been contrasted with a series of the nonaggressive type (metastasizing lesions were not considered in this study). Aggressive tumors were characteristically more likely to be ulcerative and infiltrative. They were composed of small groups of cells often displaying an irregular spiky appearance; infiltration of cells in cords, only one or two cells thick, could be seen. There was loss of peripheral palisading: the cells tended not to show differentiation. Hyalinization of the stroma was more common in the aggressive tumors. It is postulated that by utilizing these criteria, the pathologist can confidently diagnose the majority of cases and forewarn the clinician that a particular tumor is potentially aggressive. Adequate treatment and careful follow-up then become feasible.

Adult↗
PubMed1982

The follicular primordial cyst - odontogenic keratocyst.

Primordial cysts are often associated with unerupted teeth. Superimposition may result in a 'dentigerous cyst' appearance radiographically. There is usually no direct connection between the cyst lining and the follicle of the unerupted tooth. These have been termed envelopmental primordial cysts. In some instances, however, the primordial cyst actually surrounds the crown and the cyst lining is attached to the neck of the tooth in a true dentigerous relationship. We have called these lesions follicular primordial cysts. That portion of the lining immediately adjacent to the neck of the tooth consists of reduced enamel epithelium whereas the rest of the cyst is lined by typical primordial cyst epithelium. We believe that the follicular primordial cyst is extrafollicular in origin and suggest that it arises following eruption of a tooth into the cyst cavity in exactly the same manner as it would erupt into the oral cavity.

Dentigerous Cyst↗