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Biomedical subjects

M A Lemp

Publications and source records attributed to M A Lemp.

At least 73 records · Page 4Linked to original sources
PubMed1980

The effect of extended-wear aphakic hydrophilic contact lenses after penetrating keratoplasty.

I fitted nine aphakic patients who had undergone penetrating keratoplasty with extended-wear hydrophilic contact lenses (55% to 80% water content). All patients had edematous host corneas. Eight of nine developed vascularization of the graft after two to 30 weeks of contact lens wear. One patient developed a presumed Candida keratitis. The development of vascularization of the graft suggests that patients with grafted corneas are at special risk with extended-wear hydrophilic contact lenses.

Aged↗
PubMed1978

Bandage lenses and the use of topical solutions containing preservatives.

Eight patients with severe keratoconjunctivitis sicca and filamentary keratitis requiring treatment with continuous wear bandage lenses and frequent instillation of artificial tears were studied. The lenses were removed after wear from 3 to 8 weeks and subjected to ultraviolet spectrophotometric evaluation for the presence of the preservative, benzalkonium chloride. No evidence of benzalkonium chloride in the lenses was seen and no clinical evidence of corneal damage was noted. The use of topical medication containing benzalkonium chloride as a preservative in conjunction with hydrophilic lens appears to be clinically acceptable.

Benzalkonium Compounds↗
PubMed1977

Autoimmune phenomena of the conjunctiva and cornea. A case report.

A 20-year-old woman had erosions of the corneal and conjunctival epithelium and sterile stromal ulcerations of the cornea necessitating multiple corneal grafts, which were unsuccessful. An immunopathological basis for her disease was suggested by the demonstration of tissue-fixed antibodies and complement in her own conjunctival epithelium by direct immunofluorescence. In addition, circulating antibodies to normal corneal and conjunctival epithelium were demonstrated in the patient's serum by indirect immunofluorescent techniques and the titer of circulating antibodies was found to correlate with disease activity. The involvement of the fellow eye after evisceration of the first eye and reduction of systemic steroids in association with a greatly elevated level of circulating antibodies provided additional evidence for an autoimmune process. A background of immunological susceptibility was found in the patient and her family by history and immunological examination.

Adult↗
PubMed1977

Rapid development of band keratopathy in dry eyes.

In three patients, calcium deposits rapidly developed within the superficial corneal stroma. All eyes had severe desiccation, a bacterial corneal ulcer, and frequent instillation of an artificial tear preparation. Calcium deposition within the ulcer base occurred within two to three weeks.

Aged↗
PubMed1976

Cornea and sclera.

Explore the source record for details and available documents.

Acetylcysteine↗
PubMed1976

Nocardia asteroides keratitis. A case report.

An 11-year-old girl developed a corneal ulcer five days after sustaining a corneal abrasion from a fishline sinker. After more than three weeks, the epithelial defect had closed, but superficial stromal opacities in a ring-like distribution had not cleared on topical gentamicin, prednisolone 1% and atropine. Several scrapings disclosed the presence of branching hyphae on smear, eventually identified as Nocardia asteroides by culture. Although sensitivity studies suggested that subconjunctival ampicillin and hourly sodium sulphacetamide would constitute effective treatment, resolution was only partial on this regimen. Only when penicillin G drops were added did the cornea clear maximally and the epithelium heal.

Ampicillin↗
PubMed1975

Polymer adsorption at the ocular surface.

A new method for measuring ocular adsorption of polymers in solution and their resistance to removal by rinsing has been developed. The adsorptive properties of artificial tear solutions and mucin have been determined. Several solutions display properties similar to mucin and two seem to resist removal by rinsing.

Adsorption↗
PubMed1975

The effect of tear substitutes on tear film break-up time.

Twelve commercial artificial tear solutions and a newly developed one were evaluated as to their effect on tear film breakup time (BUT) in ten normal subjects. Instillation of one drop of these solutions altered the BUT in such a way that serial BUT measurements could be used as an index of retention time. Results demonstrated significantly longer retention time for three related products (Adapt, Adapette, and Adsorbotear) and a newly developed product (Alcon 0413) [Tears Naturale (Alcon TM)]. This method appears to be an accurate nonirritative way of assessing retention time of tear substitute/vehicles and demonstrate values much longer than previously reported by other methods.

Cellulose↗