Primary biliary cirrhosis and Sjögren's syndrome: case report.
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Autoimmune Diseases↗
Biomedical subjects
Louis Mandel
Publications and source records attributed to Louis Mandel.
Serum electrolytes in bulimic patients with parotid swellings.
OBJECTIVE: The purpose of this study was to determine whether electrolyte levels can be used to diagnose bulimia nervosa (BN). STUDY DESIGN: Four patients with bilateral parotid swellings and BN or suspected BN were examined. Their serum electrolyte levels were retrospectively reviewed. RESULTS: In this limited study, hypochloremia, hypokalemia, and metabolic alkalosis were present in 1 patient. One patient showed both hypochloremia and hypokalemia, whereas a third patient had only hypochloremia and a low normal serum potassium. The fourth patient demonstrated suspiciously low serum levels of Cl(-) and K(+). CONCLUSION: Because BN patients tend to be secretive regarding their disorder, serum electrolyte levels may serve as useful tools in diagnosing parotid swellings initiated by bulimia.
Adolescent↗
Radioactive iodine and the salivary glands.
Radioactive iodine ((131)I) targets the thyroid gland and has been proven to play an effective role in the treatment of differentiated papillary and follicular cancers. Simultaneously, this radioisotope hones in on the salivary glands where it is concentrated and secreted into the saliva. Dose related damage to the salivary parenchyma results from the (131)I irradiation. Salivary gland swelling and pain, usually involving the parotid, can be seen. The symptoms may develop immediately after a therapeutic dose of (131)I and/or months later and progress in intensity with time. In conjunction with the radiation sialadenitis, secondary complications reported include xerostomia, taste alterations, infection, increases in caries, facial nerve involvement, stomatitis, candidiasis, and neoplasia. Prevention of the (131)I sialadenitis may involve the use of sialogogic agents to hasten the transit time of the radioactive iodine through the salivary glands. However, studies are not available to delineate the efficacy of this approach. Recently, amifostine has been advocated to prevent the effects of irradiation. Treatment of the varied complications that may develop encompass numerous approaches and include gland massage, sialogogic agents, duct probing, antibiotics, mouthwashes, good oral hygiene, and adequate hydration.
Amifostine↗
Chronic parotitis.
Chronic parotitis is initiated when a salivary obstruction or decrease in salivary production leads to an inadequate ductal lavage. Such a condition favors a low-grade, ascending duct infection originating from the oral cavity. With the ensuing inevitable duct damage, repeated infectious flareups can be anticipated.
Adult↗
Sialadenosis associated with diabetes mellitus: a case report.
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Diabetes Complications↗
Bilateral parotid swelling: a review.
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Adenolymphoma↗
Regression of HIV parotid swellings after antiviral therapy: case reports with computed tomographic scan evidence.
Parotid swellings have been noted in approximately 5% to 10% of patients with HIV-1. These swellings are a result of lymphoproliferative activity or lymphoepithelial cyst formation in response to a viral parotid presence. Two patients with cosmetic concerns regarding parotid swellings are presented before and after antiviral therapy. Regression of the swellings after treatment is substantiated with clinical photographs and computerized tomographic scans. The successful outcome was a reflection of a diminution in viral load and some degree of immune restoration.
AIDS-Related Opportunistic Infections↗
Bilateral parotid swelling caused by sarcoidosis.
BACKGROUND: Sarcoidosis is a multisystem granulomatous disease characteristically causing bilateral hilar lymphadenopathy. Salivary gland swellings also are seen, which mandate recognition by the dental profession. CASE DESCRIPTION: The authors describe a patient whose diagnosis of sarcoidosis was tenuous. Ocular involvement and an elevated serum angiotensin-converting enzyme level suggested a diagnosis of sarcoidosis. Confirmation with a tissue biopsy was achieved only when the clinicians recognized that salivary gland swelling probably represented a manifestation of the disease. Steroid therapy was instituted. CLINICAL IMPLICATIONS: It is important for the dental practitioner to be familiar with the salivary gland manifestation of sarcoidosis. Early recognition and intervention aborts or slows disease progression.
Adolescent↗
Somatoform salivary complaints. Case reports.
Patients with salivary gland complaints are seen with a large array of signs and symptoms. Usually these patients have an underlying pathophysiological process that can account for their symptoms. However, in a significant number of patients, no known biological process can be found that would account for the patient's complaint. In such cases, somatization is a possible cause. Somatization is a frequently cited feature of patients with various forms of mental illness. In this paper, we will attempt to illustrate the classic signs of a somatoform disorder in three different patients whose diverse salivary complaints fulfill the criteria for a diagnosis of somatoform disease.
Aged↗
Preliminary steps in the diagnosis of the pleomorphic adenoma.
Patients with parotid swellings are often first seen in the dental office. The dental practitioner must be able to differentiate a neoplastic lesion from other causes of parotid swelling. Knowledge of the modalities that are available to distinguish the presence of a tumor and whether the tumor is benign or malignant is mandatory. The authors present a case report to illustrate the techniques that are used in the preliminary diagnosis of the benign pleomorphic adenoma. Final diagnosis awaits the microscopic examination of a surgical specimen.
Adenoma, Pleomorphic↗
Chronic submasseteric abscess: anatomic, radiologic, and pathologic features.
Herein we present five cases of submasseteric abscess that most commonly occurred in patients with a history dental disease. CT has been the main imaging method for diagnosing lesions in the masticator space and adjacent to the mandible; however, we found that, in some of our cases, CT defined the lesion poorly or not at all. In some cases, MR imaging defined the lesion better. Radiologic manifestations of this condition and pathologic correlations are discussed.
Adolescent↗
Primary Sjögren's syndrome.
Columbia University's Salivary Gland Center (SGC) has examined more than 6,000 patients with a variety of concerns stemming from salivary gland disease and/or salivary secretory dysfunction. Not unexpectedly, the most common patient complaint centers around symptoms associated with dry mouth. Such patients are usually first seen by the dental practitioner. Because Sjögren's syndrome (SS) causes dry mouth, and because it is a relatively common entity--encountered in about three million Americans--and because the dental profession has become aware of its classic manifestation of xerostomia, patients experiencing SS are referred in increasing numbers to the SGC for evaluation. Therefore, the authors wish to call attention to the methodology used in accurately diagnosing SS and to illustrate its signs and symptoms with a case report.
Autoantibodies↗
Sublingual salivary gland enlargement.
When examining the mouth floor, sublingual salivary gland enlargement, or hypertrophy, is commonly seen by dentists. It represents an innocuous, asymptomatic lesion that tends to proliferate into edentulous areas. It is often mistaken for a pathologic entity. Recognition avoids concern, misdiagnosis and unnecessary surgery.
Diagnosis, Differential↗
Mucoepidermoid carcinoma in the parotid gland. A case report.
Dental clinicians should be familiar with the modalities used in the clinical setting that can help to identify the presence of a tumor and to distinguish a benign from a malignant lesion. We present a case report to demonstrate the systematic approach and techniques used in the diagnosis of a malignant neoplasm, a mucoepidermoid carcinoma of the parotid gland. Ultimate diagnosis is determined by microscopic analysis of a surgical specimen.
Aged↗