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Biomedical subjects

L Walker

Publications and source records attributed to L Walker.

At least 253 records · Page 14Linked to original sources
PubMedDate not supplied

Human fetal pancreas transplants.

Human fetal pancreatic islet tissue has several advantages as a transplant source for the amelioration of insulin deficiency in patients with Type I diabetes mellitus. It is now possible to obtain viable tissue, store and ship the tissue without adverse effects on the insulin secretory capacity, and transplant either minced tissue or isolated islet-like cell clusters following digestion and culture into animal models or man. A number of centers have undertaken studies of human fetal pancreatic allografts in man. Optimal results have occurred when pooled tissue from six to 20 donors has been implanted and a number of sites have been studied. The author's own experience in four recipients who did not receive immunosuppression has documented insulin secretion for up to 1 year in the absence of an anticytoplasmic islet cell antibody response on the part of the recipients. Nevertheless, the procedure has not resulted in insulin independence for the recipients and the implanted tissue has not secreted insulin in response to a glucose-amino acid challenge in a normal physiologic pattern. Thus, human fetal pancreatic transplantation for the treatment of Type I diabetes remains an experimental approach.

Animals↗
PubMedDate not supplied

Effects of retention interval length on young and elderly adults' memory for spatial information.

Adult age differences in spatial memory following retention intervals of various lengths were examined in 47 young and 56 elderly subjects who recalled spatial information following either a 3-, 15-, or 30-min retention interval. The elderly adults were significantly less accurate than the young adults following the 30-min retention interval only; there was no statistically significant effect of age at the 3-min and 15-min retention intervals. It is concluded that younger adults experience greater temporal stability of spatial memory than do older adults, and the relevance of the present findings for Craik's environmental support hypothesis is discussed.

Adolescent↗