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Biomedical subjects

L Vacca

Publications and source records attributed to L Vacca.

At least 55 records · Page 3Linked to original sources
PubMed1977

Effect of maternal vitamin A excess on S-100 in neonatal rat cerebellum: a preliminary study.

Pregnant rats were administered a teratogenic dose of vitamin A excess on Days 17 and 18 of gestation and intubation controls received the vehicle alone. Pups were sacrificed at birth or on postnatal Days 5 or 10; the cerebellum was removed, frozen, and fixed in preparation for immunohistochemical localization of the brain specific protein, S-100. Vitamin A produced a transient delay in the appearance of S-100 in the external granular layer which was no longer evident on Days 5 and 10. These findings corroborate autoradiographic evidence that vitamin A temporarily interferes with neurogenesis. However, the early damage results in permanent behavioral deficits in adulthood despite apparent cytochemical repair.

Animals↗
PubMed1976

[Development of the internal ear in albino rat embryos subjected to transverse acceleration at + 3 G. Note 3: First observations on the ultrastructural picture of the labyrinth. 1st ultrastructural studies of the labyrinth].

Marked body size reduction (minus 50.5%), and delayed head and body skeletal development were noted in albino rat embryos following exposure of the mother to +/- 3 G acceleration for 3 hr/day between the 10th and 19th day of pregnancy. In addition, electron microscope examination of the inner ear showed signs of greater functional activity of the labyrinth, unaccompanied by reduction of development. Semicircular canal cells and size, in fact, were normal in the crests and at a distance from the latter. There was a marked increase in the number of mitochondria in the cells, in ER area and volume, and A and B glycogen granule richness compared with the controls, these being all signs of considerable activity. The findings substantiate prior histological and histochemical observations: the physiological stimulus offered by acceleration is highly specific for the inner ear structure, particularly that of the labyrinth, to the point where the handicap imposed by the circulatory hypoxia caused by such acceleration, by disturbing the mother-foetus circulation, is overcome.

Acceleration↗
PubMedDate not supplied

New data on the genetic structure of the population of Sicily: analysis of the Alia population (Palermo, Italy).

The distribution of 13 genetic markers (AB0, Rh, ACP, ADA, AK, ESD, GLO, PGD, PGMl, SOD, GC, TF, and PI) were studied in a sample from the Alia population of Sicily, Italy. A total of 34 alleles were detected. In comparison with other Sicilian populations, Alia always appeared genetically distinctive, either in terms of overall genetic diversity or for the number of unique alleles present. The results are consistent with previous studies that show no genetic uniformity within the island. More specifically, the data support the genetic divergence of the eastern and western halves of the island and highlight genetic boundaries that run through Sicily and divide it into three distinct areas.

Alleles↗