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Biomedical subjects

L Simon

Publications and source records attributed to L Simon.

At least 253 records · Page 14Linked to original sources
PubMed1979

[Prostatic osteosis. Retrospective study of 110 cases treated with high-dose estrogens].

On the basis of 110 prostatic osteoses that were histologically proven, constantly painful and demonstrated by X-ray, treated by early estrogenotherapy using very high doses, backed up by a high-dose maintenance estrogenotherapy, the authors study the clinical, radiological, histological and biological profile of this metastatic cancer, as well as the response to treatment. The median actuarial survival time of the patients studied is 18.5 months. No statistically significant prognostic correlation was found. Only patients who are clinically estrogen-sensitive, are suffering from bone metastases without a combined visceral conditions, and have a normal initial rate of alcaline phosphates, tend to have a better prognosis (median actuarial survival 31 months versus 18.5 months for the overall population).

Adult↗
PubMed1979

[Multiple myeloma of bones. Retrospective study of prognostic factors based on a series of 243 patients].

The authors have made a retrospective study of 243 cases of multiple myelomas, most of them treated with alkylating agents. The average age at the time of diagnosis was 65 years (+ 10). The ratio of the sexes was 1 : 1. Seventy two per cent of the patients had a bone rating of 2 or 3 according to the criteria of Durie and Salmon. Fifty-eight per cent of the patients were anemic (Hg 12 g per cent), with less than 15 per cent being leucopenic or thrombopenic. Hypercalcemia (105 mg 0/00) was noted in 27 per cent of cases. The distribution of immunochemical types is as follows : IgG, 51.5 per cent; IgA, 28 per cent; pure Bence Jones, 20.5 per cent. The respective percentages of kappa and lambda light chains were 64.2 per cent and 35.8 per cent. In this series, nearly 80 per cent of the patients were at phase III according to the classification of Durie and Salmon, and 30.8 per cent at phase B. The median survival, including all phases, increased from 8 months without alkylating agent, to 20 months with melphalan and/or cyclophosphamide. The factors influencing the survival of the patients treated were age, the hemoglobin level, calcemia, renal deficiencies, the immunochemical type, the stage of the disease, and the response to alkylating treatment. The value of these different prognostic factors is discussed.

Adult↗
PubMed1979

[Biosynthesis of PGE2 and PGF2 alpha in normal and pathological human synovial fluid].

The biosynthesis capacity of PGE2 and PGF2 alpha in normal and pathological (rheumatoid arthritis and osteo-arthrosis) synovialis was studied using the radio-immunological method, simultaneously on homogenized tissues and the microsome fraction, with or without addition of exogenous arachidonic acid. Among the results obtained, the most significant concern rheumatoid polyarthritis: a net increase in PGF2 alpha and especially in PGE2, more pronounced in the homogenized emulsion than in the microsomial fraction. Exogenous arachidonic acid increases the biosynthesis capacity of the PG. The prospective interest of this model is underlined: the possible introduction in the incubation medium of various drugs, making it possible to study the various factors taking part in the biosynthesis of PG (phospholipase A2 and prostaglandin-synthetase).

Arachidonic Acids↗
PubMed1979

[Rheumatoid foot. Practical podiatric problems].

The rheumatoid foot may obtain relief from practical local measures that prevent the excessive use of drug therapy. These include the decrease in inflammatory phenomena thanks to local injections of corticoids (eventually synoviorthesis), the prevention of deformations through the use of various apparatuses, the protection of the skin of the palms and the nails that are fragile and rapidly altered by local hygiene care. The maintaining of sufficient support and normal walking through the use of plantar prostheses or custommade toe prostheses and by wearing shoes of excellent quality, the maintainance and preservation of articular flexibility and muscular trophicity by adapted kinestherapy and ergo therapy. Major deformations that, while they cannot be modified do not require surgery, can be alleviated with "custom-made shoes" which are at the same time light, adapted and good looking. Whatever the treatment used, local measures are the most effective at any given time.

Adrenal Cortex Hormones↗
PubMed1979

[Value of preoperative investigations in the so-called "cervical myelopathy" (author's transl)].

The particular value of clinical, radiological and electromyographical features is compared in 42 patients with motor deficit related to cervicarthrosic myelopathy or amyotrophic lateral sclerosis. The initial onset of the disease was identical (motor deficit and long tracts pathways involvement). Three different groups were identifyed according to the evolution: -- Group I: (13 cases): true lateral amyotrophic sclerosis which were not operated on. -- Group II (10 cases): myelopathy called "cervicarthrosic" because of radiological findings which were operated on but had the same steady worsened course as a lateral amyotrophic sclerosis. -- Group III (19 cases): cervical myelopathy which had surgery. The operation brought about stabilization or fairly good recovery over the 18 months following at least. From a clinical aspect, the "Lhermitte sign" or objective sensitive deficit are strongly significant for cervical myelopathy. On the contrary, diffuse fasciculations specially in the tongue seem to be mostly found in lateral amyotrophic sclerosis, whereas they are restricted into the paralysed area in cervical myelopathy. Electromyographic examination is decisive: simple activity with high frequency motor units (increased amplitude and polyphasic waves) or "preponderant potentials" into a cranial nerve territory or three segments of the lower limbs are frequently found in lateral amyotrophic sclerosis. These electromyographic features are less significant in the upper limbs. The neuroradiological findings lonely cannot assert definitely the cervicarthrosic origin of the myelopathy but visualize the conflicting situation between the spinal cord and the cervical canal and allow to choose the surgical procedure.

Aged↗
PubMed1978

Mechanism of action of the spasmogenic activity of penthylenetetrazol and of 1,2,3,4-tetrahydroisoquinolines on rat stomach fundus strips.

Spasmogenic activity of penthylenetetrazol (PTZ) and 1,2,3,4-tetrahydro-isochinoline (THI) derivatives was gradually reduced during storage of their solutions as tested on rat isolated stomach fundus strips. Spasmogenic activity of both PTZ and THI derivatives could be modified by prior exposure of the solutions to electrostatic field and to rotating magnetic field or ultrasound treatment. As a consequence of rotating magnetic field treatment, ED50 values for 1-phenyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isochinoline-hydrochloride (S-23), PTZ and for PTZ crystallized from an ether solution of PTZ (PTZA) doubled, i.e. their activity was reduced by 50 per cent. After an exposure to rotating magnetic field, intrinsic activity of S-23 fell only by 10 to 20 per cent, while after the same treatment the fall in intrinsic activity of PTZ was more pronounced (40 to 50 per cent). Activity of PTZA changed similarly as that of PTZ. Activity of S-23 was similarly modified by exposure of its solution to electrostatic or rotating magnetic field. On the other hand, intrinsic activity of PTZ solution exposed to electrostatic field was twice as high as that of the control PTZ solution. Affinity and intrinsic activity of PTZ solutions diminished after ultrasound treatment. The fall in the activity of PTZ solution of low concentration was greater after the same ultrasound treatment, but its convulsive activity measured in vivo remained unchanged. Spasmogenic activity of ultrasound-treated PTZ reappeared after the solution had been dried under vacuum and then the residue crystallized and redissolved in water. These findings allow the conclusion that the observed changes in activity could be the result of spontaneous or field-evoked alterations in molecular state (orientation, association etc.) conformation. The fact that the activity of PTZ solution measured in vivo did not change during storage supports this assumption.

Animals↗
PubMed1978

[Aspects of the crossed thoracobrachial syndrome as seen in rheumatology].

On the basis of 12 personal observations it is pointed out that the thoracobrachial syndrome may become apparent from pain or paraesthesia of the arm. These symptoms typically appear in certain positions or on effort. Essential arterial or venous complications require early diagnosis, which is only possible by vascular exploration (arteriography or phlebography with radiographs with abduction of the arm). The value of clinical changes appears to be very restricted. Simple surgery-resection of the first rib- eliminates all possible multiple compression causes and is indicated in serious or very incapaciting forms of the syndrome.

Adolescent↗
PubMed1978

[Tomodensitometry in osteoarticular pathology. Preliminary results].

From the investigation of 180 patients, the preliminary results of tomo-densitometric study ("scanning") of the locomotor system are presented. The technique permits investigation in the transverse spatial plane, which is ignored in conventional radiology. We feel this to be a major advantage in osteo-articular disease, especially for the spine (measurement of the diameter of the canal, analysis of the posterior structures), the sacro-iliac joints, hip joints (easy-measurement of the angles of anteversion) and patello-femoral joints. The densitometric measurement is the second advantage. It allows the estimation of the degree of bony calcification of any bone in the body with great precision. The preliminary study already demonstrates the limitations of the technique (exploration of a single transverse plane, edge effect, and necessity for a new anatomy).

Bone Diseases↗