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Biomedical subjects

L Scott

Publications and source records attributed to L Scott.

At least 469 records · Page 26Linked to original sources
PubMed1992

Hospitals gird to fight 'disease of the future'.

With cancer expected to strike one in three Americans now living, the disease is transforming the way hospitals are organized and the directions in which they will grow in the 1990s. Not only is cancer altering the way hospitals treat patients, but it's channeling patients into two arenas that hold the best chances for future growth--outpatient services and preventive medicine.

Ambulatory Care↗
PubMed1992

The personnel touch in mapping strategies.

Human resources departments are playing an increasingly important role in planning their hospitals' long-term competitive strategies, according to this year's MODERN HEALTHCARE survey of employee benefits and human resources issues. A human resources executive is a member of the strategic planning team at 52% of the hospitals that responded to the survey, and the human resources department assists in planning at half of the other hospitals.

Data Collection↗
PubMed1992

Winning designs shed lots of light.

From an outpatient surgery center in Minnesota to a teaching hospital in South Korea, each of the nine projects recognized in the 1992 Design Awards Competition uses sunlight well, one quality desirable in contemporary architecture. The winning designs also share clear organization, the ability to expand easily and exteriors that complement their surroundings.

Architecture↗
PubMed1992

1992 up & comers.

Explore the source record for details and available documents.

Awards and Prizes↗
PubMed1992

Contract management survey.

More hospitals are looking to contract management firms for help in controlling rising costs and handling complex reimbursement systems. Companies are responding to hospitals' changing needs by providing innovative services. Total hospital contracts rose 10.4% last year, according to the 94 companies responding to MODERN HEALTHCARE's 1992 contract management survey.

Commerce↗
PubMed1992

Atlanta's Grady renovating for the future.

Grady Memorial Hospital in Atlanta has opened a new emergency-care center, designed around a fast-track system. It's only part of a massive $318 million renovation affecting nearly every department in the public hospital. When the project is completed in 1995, it will allow Grady to meet building codes, increase its total number of beds to 1,024 and eliminate duplicative services.

Efficiency↗
PubMed1992

Construction & architects survey. Providers may see lower building bills.

Stagnation in the construction industry could spell increased competition and lower prices for healthcare projects in the next few years. Architects forecast that the number of projects will remain steady despite the soft economy, with continued emphasis on ambulatory-care facilities and critical-care areas. These are among the findings of Modern Healthcare's annual survey of healthcare design and construction.

Architecture↗
PubMed1992

Characterization of a light-regulated gene encoding a new phycoerythrin-associated linker protein from the cyanobacterium Fremyella diplosiphon.

Cyanobacteria utilize multimeric protein complexes, the phycobilisomes, as their major light-harvesting antennae. Associated with the chromophorylated phycobiliproteins in these complexes are nonpigmented proteins, designated linker proteins. These linker proteins are believed to mediate assembly of the phycobilisome and energy transfer to the photosynthetic reaction center. We cloned and sequenced a gene, cpeE, encoding a previously uncharacterized linker protein which is expressed in green light in Fremyella diplosiphon. This gene is part of an operon containing two other phycoerythrin-associated linker genes, cpeC and cpeD. Transcription of the cpeCDE operon in green light results in two predominant species of mRNA of approximately 2,100 and 3,200 nucleotides. The shorter transcript encodes only CpeC and CpeD, while the longer contains the coding regions for all three linker proteins. By altering the pH of the resolving gel and the running buffer during sodium dodecyl sulfate-polyacrylamide gel electrophoresis, this third linker protein CpeE can be resolved from the rod-core linker and the other rod linker proteins. The three proteins have an overall similarity of approximately 62%, and the genes encoding the three proteins are approximately 59% identical.

Amino Acid Sequence↗
PubMed1990

Endothelial cell stimulation of smooth muscle glycosaminoglycan synthesis can be accounted for by transforming growth factor beta activity.

Endothelial cell conditioned medium (ECCM) contains a factor which markedly stimulates smooth muscle cell (SMC) glycosaminoglycan (GAG) synthesis. We report here that the factor responsible is transforming growth factor beta (TGF-beta) as assessed by (1) protease and thiol sensitivity, (2) heat and acid enhancement of ECCM activity, and (3) neutralisation of ECCM activity by anti-TGF-beta-immunoglobulin. Anti-TGF-beta-neutralisation was effective against increases in both sulphated and non-sulphated GAG. Previous studies showed that ECCM from EC of varying densities stimulated individual GAG to varying degrees. ECCM from low density EC preferentially stimulated hyaluronic acid (HA) whereas ECCM from intermediate and high density cultures stimulated increasing amounts of sulphated GAG. Exposure of SMC to varying concentrations of TGF-beta produced a similar pattern Exposure of SMC to varying concentrations of TGF-beta produced a similar pattern of response. Very low amounts of TGF-beta (less than 10-500 pg/10 cells) stimulated a marked and significant increase in HA synthesis. Increase in chondroitin sulphate 4/6 was most marked at TGF-beta levels from 500-1000 pg/10(6) cells. At levels above 1000 pg/10(6) cells both HA and sulphated GAG synthesis decreased but still remained elevated above controls. These findings indicate that TGF-beta alone can account for the changes in SMC GAG synthesis stimulated by ECCM. It was also found, however, that heat-treated SMC conditioned medium stimulated SMC GAG synthesis, thus SMC may contribute to the control of their own GAG synthesis through autocrine TGF-beta activity.

Animals↗
PubMed1990

Clinical evaluation of an acetaminophen meter for the rapid diagnosis of acetaminophen intoxication.

STUDY OBJECTIVES: To test the accuracy of a newly developed meter that determines serum acetaminophen concentration after a 30-second analysis of one drop of whole blood. DESIGN: Sixty-six blood samples from patients with known or suspected drug overdose were analyzed for the presence of acetaminophen. In all cases determination of serum acetaminophen concentration was performed simultaneously with the meter and by a reference laboratory. SETTING: Eligible patients were those who presented during a nine-month period to the emergency departments of two tertiary care hospitals (including a pediatric hospital). RESULTS: Thirty-one specimens had a laboratory-confirmed detectable acetaminophen concentration. The meter identified these toxic specimens in all cases; there were no false-negatives (sensitivity, 100%). Among the 35 specimens not containing acetaminophen, the meter invariably confirmed a nondetectable serum acetaminophen concentration (specificity, 100%). Acetaminophen measurements by the meter correlated strongly with laboratory determinations (r = .985, P less than .001). Repeated testing of one specimen documented the precision and reproducibility of the meter's analysis; mean coefficient of variation was .08 in measuring toxic acetaminophen concentrations. Drug coingestion had no significant effect on the accuracy of the meter. Instrument accuracy was maintained after more than 100 uses without recalibration. CONCLUSIONS: This meter identifies the possibility of rapid and accurate determinations of serum acetaminophen concentration. The instrument is ideally suited for patients with acetaminophen poisoning in whom expeditious and appropriate administration of antidotal therapy is desired.

Acetaminophen↗
PubMed1990

Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia.

A randomized, double-blind, placebo-controlled, parallel-group clinical trial was carried out to compare 24-week periods of treatment with 1 g acetyl-l-carnitine twice daily and placebo in the treatment of patients with dementia of the Alzheimer type. A total of 36 patients entered the trial, of whom 20 patients (7 active, 13 placebo) completed the full 24 weeks. Whilst several of the efficacy indices showed little change in either group during the trial, there was an apparent trend for more improvement in the acetyl-l-carnitine group in relation to the Names Learning Test and a computerized Digit Recall Test, both related to aspects of short-term memory. Similarly, there was a trend for reaction time in the computerized classification test to show less deterioration in the active treatment group. Changes within groups, and changes between groups, failed to reach statistical significance, at least partially because of the small number of patients available for analysis. Two indices of overall therapeutic benefit showed a trend for less deterioration in the active-treatment group than in the placebo group. Nausea and/or vomiting occurred in 5 patients in the acetyl-l-carnitine group. Laboratory tests revealed no signs of drug toxicity. The results suggest that acetyl-l-carnitine may have a beneficial effect on some clinical features of Alzheimer-type dementia, particularly those related to short-term memory.

Acetylcarnitine↗