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Biomedical subjects

L Scott

Publications and source records attributed to L Scott.

At least 451 records · Page 25Linked to original sources
PubMed1993

Neutralizing antibodies to human interleukin 6 reverse hypercalcemia associated with a human squamous carcinoma.

Bone resorbing cytokines may be associated with abnormalities in bone cell function and calcium homeostasis in a number of pathological conditions. One of these cytokines is interleukin 6 (IL-6), which is a multifunctional cytokine which has been shown to be associated with increased formation of bone resorbing osteoclasts in vitro. In this report, we demonstrate that neutralizing antibodies to human IL-6 lower the blood calcium in nude mice carrying a human tumor associated with increased IL-6 production. There was no effect on blood calcium in hypercalcemic nude mice carrying tumors not associated with increased IL-6 production and normocalcemic tumor-bearing nude mice. These results suggest that increased production of IL-6 may contribute to disturbances in calcium homeostasis in some malignancies, and suggest that neutralization of IL-6 effects can lower the serum calcium in these tumors.

Animals↗
PubMed1993

The influence of maternal nicotine exposure on neonatal lung alveolar epithelial status: an electron microscope study.

The aim of the present study was to investigate the effect of maternal nicotine exposure (1 mg nicotine/kg body mass/day) on neonatal lung alveolar epithelial cells. Rats (Wistar descendants) were used. The data illustrate that maternal nicotine exposure during pregnancy and lactation resulted in alveolar fenestrations, blebbing and rupturing of the blood-air barrier. The type I pneumocyte appears to be more sensitive to the effect of nicotine than the type II pneumocytes.

Animals↗
PubMed1993

Combined intrauterine triplet and ectopic pregnancy following pronuclear embryo transfer in a patient with elevated serum progesterone during ovulation induction.

We present a case of heterotopic pregnancy occurring after ET of pronuclear-stage embryos. This case demonstrates that pronuclear embryos have a good implantation potential and suggests that the potentially adverse effect of high follicular-phase serum progesterone levels on endometrial development might be offset by early ET of pronuclear embryos. This, however, is speculative and deserving of formal scientific evaluation. Finally, we are reminded that heterotopic pregnancy complicates 1 to 3% of IVF-ET pregnancies and that, even with a high index of suspicion, most heterotopic pregnancies are diagnosed after rupture. All assisted reproductive programs should be reminded frequently that ectopic and heterotopic pregnancies do occur and can lead to serious consequences if left undetected.

Adult↗
PubMed1993

Self-discrepancies in clinically anxious and depressed university students.

Self-discrepancy theory proposes that anxiety and depression are the result of different types of conflicting self-beliefs. This study examined self-discrepancies in four groups of university students who completed a questionnaire assessing levels of self-discrepancy and were characterized by the following disorders: (a) depression, (b) anxiety, (c) both anxiety and depression, or (d) no psychiatric disorder. As predicted, subjects with anxiety or depressive disorders had higher levels of self-discrepancy than normal subjects. Depressive subjects had higher levels of actual:ideal discrepancies than nondepressive subjects. Anxious subjects (with or without depressive disorders) had higher levels of actual:ought discrepancies than nonanxious subjects (normals and depressed-only subjects). Results provided general support for self-discrepancy theory in accounting for depressive and anxiety disorders.

Adult↗
PubMed1993

Nutritional correlates of atrophic glossitis: possible role of vitamin E in papillary atrophy.

Atrophy of the filiform papillae of the tongue is a sign of malnutrition. However, papillary atrophy has not been correlated with laboratory indices of nutritional status. We studied photographs of tongues from 30 elderly subjects and determined the percentage of normal papillary development (%NPD) relative to a reference photograph. We also determined 16 nutritional blood levels and used stepwise multiple linear regression to examine their relationship to %NPD. We found that %NPD correlated significantly (p < 0.0031) with levels of vitamin E and prealbumin, but not with 14 other laboratory indices. Subjects with overt atrophic glossitis (%NPD < 50%) tended to have multiple nutritional deficiencies. The high correlation of plasma vitamin E levels with %NPD may be related to its role as an antioxidant and in the maintenance of cellular membrane integrity.

Aged↗