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Biomedical subjects

L S Levin

Publications and source records attributed to L S Levin.

At least 163 records · Page 9Linked to original sources
PubMed1976

Lymphagiomas of the alveolar ridges in neonates.

Blue-domed, fluid-filled lesions on the alveolar ridges of neonates were noted in 3.7% of all normal black newborns examined. None were found in whites. On microscopic examination of eight such lesions, the diagnosis of lymphangioma was made. These lymphangiomas should not be confused with Epstein's pearls, Bohn's nodules, eruption cysts, or mucous retention phenomena. The natural history of such lymphagiomas is unknown. However, spontaneous regression was noted in several cases.

Alveolar Process↗
PubMed1975

Oral findings in the Morquio syndrome (mucopolysaccharidosis IV).

The Morquio syndrome is characterized by a specific pattern of platyspondylia, corneal opacities, keratosulfate excretion in the urine, and dental abnormalities. Oral examinations were performed on twelve patients with the condition. The maxillary anterior teeth were widely spaced and flared. The posterior teeth were tapered and had pointed cusp tips. The enamel was of normal hardness, and in some patients the surface was pitted. In roentgenograms, the enamel was less than one fourth its normal thickness but was of normal radiodensity. The prevalence of caries may have been reduced. The hard palates were broad and flat. The dental abnormalities in the Morquio syndrome are of a type that is unique among the group of genetic mucopolysaccharidoses. Our findings therefore support the conjecture that the biochemical defect in this condition is different from that which occurs in the other mucopolysaccharidoses.

Adolescent↗
PubMed1975

Periodontosis in sibs.

Periodontosis is an idiopathic degeneration of the periodontium which results in migration and loss of teeth. The disease begins in the regions of the incisors and first molars. Late in the disease, other areas of the dental arches may be involved. The gingivae are not initially inflamed, and there are no associated systemic abnormalities. Local irritants cannot account for the marked alveolar destruction which leads to the tooth loss. Several heritable syndromes and periodontitis also may be associated with alveolar bone destruction. Periodontosis can be differentiated each of these on the basis of negative laboratory tests, lack of associated anomalies, distinctive pattern of bone loss and timing of onset of gingival inflammation. A family in which periodontosis was present in three of six sibs and in which ichthyosis was segregating independently of periodontosis is reported.

Adolescent↗
PubMed1975

A survey of air and population lead levels in selected American communities.

The concentration of lead in the ambient atmosphere was determined at 59 sampling sites in eight American communities during the period 1968-71. Nineteen sampling sites had existed in a similar survey in 1961-62. At 14 of these sites the lead-in-air value was found to be higher in the current study than in 1961-62. The observed annual mean atmospheric concentration of lead varied from 0.14 mug/m3 (Los Alamos) to 4.55 mug/m3 (Downtown Los Angeles). Higher lead values were associated with urbanization. The concentration of lead in the blood of specific well-defined populations was determined. Such populations lived in geographic proximity to specific air sampling sites. In the three metropolitan areas from which both urban and suburban population groups had been obtained, the mean blood lead levels were significantly higher in the former. In two of the three areas the blood lead level was higher in urban smokers and non-smokers than in the corresponding suburban populations, classified by smoking habits. At each location the concentration of lead in the blood of smokers was greater than that in the blood of non-smokers. The magnitude of the observed urban-suburban difference (for populations comparable in smoking habits) ranged from 0.9 mug/100 gms to 4.5 mug/100 gms. It is probable that these observations partially reflect lead absorption from ambient atmospheres differing in lead concentration. There was no significant concordance between the ranking by site of mean air lead levels and that of the mean blood lead levels prevalent in the related populations. The observation that urban levels of blood lead and higher than suburban levels, but that air concentrations of lead are not clearly reflected in blood lead levels on a general national basis, suggests that factors other than the atmospheric lead level are of relatively greater importance in determining the blood lead levels in population groups. No relationship was established between age of participant and the blood lead level. In husband-wife pairs, presumably exposed to similar diets and atmospheres, the males had significantly higher blood lead levels than did the females. This difference could not be attributed to smoking habits or to hematocrit levels. The possibility that the difference was due to dissimilar quantities of foods in the respective diets of men and women was not examined. Studies of dietary lead levels showed them to be generally lower than commonly reported in the literature, 100 mug/day being a closer approximation in the population studies than the widely quoted 300 mug/day.

Air↗
PubMed1975

Carcinoma in the Gardner syndrome: a case report.

Carcinoma of the colon is commonly seen in the Gardner syndrome and familial polyposis of the colon. Therefore early detection of these symdromes in families and careful follow-up are important. During a study of families at high risk of developing colorectal cancer, an asymptomatic 19-year-old female was found to have the Gardner syndrome. Although barium enema examination was negative, colonoscopy revealed the presence of polyps; biopsy of one polyp revealed carcinoma-in-situ.

Adult↗
PubMed1975

Otodental dysplasia: a "new" ectodermal dysplasia.

Otodental dysplasia is an ectodermal dysplasia characterized by abnormal crown morphology of the teeth and sensorineural hearing loss. It was documented in six generations of a kindred of Italian extraction. Thirty-three of the 119 examined family members were affected. Twenty-six persons had characteristic dental anomalies combined with a hearing loss. Two had the dental anomalies alone, four had a hearing loss only and one of those with dental anomalies could not be tested for hearing. The teeth of the 29 with dental anomalies had large, bulbous crowns. The normal relationship between cusps and grooves was obliterated. Molars, both deciduous and permanent, were involved. Deciduous canines were large and bulbous. Absence of premolars was documented in 14 of the 29 individuals with abnormal teeth. Those premolars which were present were frequently small. Radiographs of the teeth showed denticles and taurodontia. Twenty-six of the 30 individuals with a hearing loss had concomitant dental anomalies. Of the four with isolated hearing loss, one was proven to have the syndrome. The remaining three were conjectured to be affected. The age of onset of the hearing deficit ranged from early childhood to middle age. The results of a chi-square test supported autosomal dominant inheritance. The pleiotropy in this syndrome is postualed to be due to a genetic defect in the neuroectoderm.

Adolescent↗