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Biomedical subjects

L S Levin

Publications and source records attributed to L S Levin.

At least 145 records · Page 8Linked to original sources
PubMed1979

Adenomatoid odontogenic tumor: ultrastructural demonstration of two cell types and amyloid.

A typical adenomatoid odontogenic tumor removed from a 13-year-old female was studied by light and electron microscopy. The tumor was composed of two types of epithelial cells: Type I cells were cuboidal and occurred in nests or formed ductlike structures and Type II cells were smaller and spindle shaped. The formation of extracellular masses of amyloid was found in association with Type I epithelial cells, and amyloid formation was not observed in association with Type II cells. Results suggest that the lesion is of enamel organ origin, derived from cells of the inner enamel epithelium at the pre-ameloblastic stage, stellate reticulum and stratum intermedium. The origin of this amyloid material is unknown; however, it may be of enamel protein origin which, like amyloid, may have a beta-protein conformation.

Adolescent↗
PubMed1978

Treatment of the ameloblastoma: a controversy.

Treatment of the ameloblastoma should be re-evaluated based on microscopic behavior. We suggest that conservative therapy is the initial treatment of choice. Although medullary bone is invaded by tumor cells, compact bone only is eroded. Therefore, treatment should be directed at removal of involved medullary bone, leaving as much medial and lateral cortical plates and inferior mandibular border as possible. Four patients with ameloblastoma treated conservatively are presented. Evaluation from 21 months to seven years after initial therapy revealed marked bone regeneration. Three of the four had smaller lesions remaining, requiring less radical surgery than would normally have been performed initially. No tumor was evident on rebiopsy of the fourth patient. Conservative treatment and proper follow-up were acceptable methods of initial treatment in our cases.

Adult↗
PubMed1978

The Rieger syndrome.

Fourteen patients with hypodontia and the ocular features of the Rieger syndrome were examined for the presence of systemic anomalies. A periumbilical defect that consisted of failure of the periumbilical skin to involute was seen in ten of the thirteen evaluated for the defect. Three others had scars over the umbilical area and had a history of surgery for herniation. In addition, four males in one family and one male from another family had hypospadias. None of several other anomalies reported to be components of the Rieger syndrome by other authors was detected in the fourteen patients. The mode of inheritance in the familial cases studied was compatible with autosomal dominance. The results of this study indicate that the Rieger syndrome is an autosomal dominant syndrome whose cardinal features are hypodontia, goniodysgenesis, and failure of the periumbilical skin to involute properly.

Abnormalities, Multiple↗
PubMed1978

Digital sensibility following replantation.

The amputated digit serves as an excellent model for the examination of digital nerve repair. When amputation is complete, there is no question of cross-over or anomalous innervation. The sensibility of 35 replanted digits in 29 patients was evaluated. Sensory return was related most closely to restored digital vascularity, as measured by Allen test, pulse volume flow, and Doppler. Level of amputation, mechanism of injury, and age of patient also affected ultimate sensation. All patients experienced cold intolerance and some were considerably disabled because of it. The severity of cold intolerance with pain and requiring prolonged rewarming was directly proportional to digital vascularity. When one digital artery thrombosed, ipsilateral digital sensation was not diminished as long as flow through the contralateral vessel was adequate. Two-point discrimation in our series was not as good as that reported for digital nerve repair in the nonamputated digit. Establishing and maintaining adequate digital flow at the time of replantation is essential to obtain good digital sensibility and to avoid symptoms of cold intolerance.

Adolescent↗
PubMed1977

Hearing patterns in Morquio's syndrome (mucopolysaccharidosis IV).

The hearing status of 18 patients with Morquio's syndrome (mucopolysaccharidosis IV) was evaluated. All three patients under age 8 years had a conductive hearing loss. Fourteen of 15 patients 8 years of age and older had a mixed or sensorineural hearing loss; one had normal hearing. Six patients wore hearing aids. By the end of the first decade of life, most persons with Morquio's syndrome may be expected to have either a mixed or sensorineural hearing loss. Amplification may be required.

Adolescent↗
PubMed1977

A postaxial polydactyly-dental-vertebral syndrome.

Three patients with postaxial polydactyly and other abnormalities of the hands and feet, hypoplasia and fusion of the vertebral bodies, and dental abnormalities are reported. Two were sisters born to normal unrelated parents; the other patient was the male offspring of a consanguineous marriage. We suggest that this constellation of abnormalities represents a recessively inherited syndrome.

Abnormalities, Multiple↗
PubMed1977

A heritable syndrome of craniosynostosis, short thin hair, dental abnormalities, and short limbs: cranioectodermal dysplasia.

Five children are reported with dolichocephaly (with sagittal suture synostosis in three), sparse, slow-growing, fine hair, epicanthal folds, hypodontia and/or microdontia, short span, brachydactyly and brachypodia, and narrow thoraces. Radiologic abnormalities were noted chiefly in the skull, chest, and limbs. Intelligence was normal. The pattern of inheritance is compatible with an autosomal recessive trait.

Abnormalities, Multiple↗
PubMed1977

Forces and issues in the revival of interest in self-care: impetus for redirection in health.

Most health and medical care is provided by families and individuals to themselves. Self-care has become a salient public issue because of the emergence of chronic diseases as leading causes of death and disability; a new awareness of the limitations of conventional medical care; and social changes which emphasize greater personal control. Challenges arise in definition of professional roles in relation to organized self-care efforts, economic implications, and development of appropriate social policies. A negative potential exists for exploitation by interests which would limit movements for more equitable and higher quality health services, but should not obscure the positive potential for a strengthened partnership in health between the lay and professional worlds.

Acute Disease↗