Glandular fever-like syndrome, pulmonary eosinophilia and asthma associated with carbamazepine.
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Biomedical subjects
Publications and source records attributed to L Rosenbloom.
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In the two years following the implementation in Liverpool of a case conference system for dealing with non-accidental injury to children, 76 children were discussed at 73 such conferences. Factors in both the children and their families were identified as predisposing to non-accidental injury, notably male sex, illegitimacy, low birthweight, previous injuries in the children, the mothers having become pregnant at an early age, and the families having environmental stress factors. The evolving rôle of the case conference system in providing support for affected families is discussed.
Of the infants with spina bifida referred to a neonatal surgical unit over three years and denied early closure of the myelocele, a significant proportion survived long enough for procedures to drain hydrocephalus to be needed. The key decision in the management of this condition is not whether myeloceles should be closed but whether hydrocephalus should be treated.
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The effects of vigabatrin were studied over a 6-month period in 43 patients with intractable epilepsy. Children with complex partial seizures, with or without secondary generalization, responded best with more than one-half achieving a greater than 50% reduction; generalized tonic-clonic seizures also improved but there was no significant change in absence or myoclonic seizures. Four patients are seizure-free on monotherapy with vigabatrin. The drug was well tolerated with few side effects.
Clinical patterns, aetiological factors and utilization of services were studied in 40 families who had more than one handicapped child. By retrospective review of the case notes and interviewing consenting parents (90%), data relating to diagnosis, investigations, genetic counselling, social circumstances and help received were obtained. Both children had the same disorder in 31 families, however in only nine of these families did the children have a specific diagnosis. Non-specific mental retardation was the commonest disorder (40 children). Of the 673 special investigations performed, only 14 were diagnostic. Genetic counselling had been given to only 19 families. Thirty-two of the families had remained as stable units and of the children, 51 received attendance allowances and 21 had periods of respite care. The implications of these findings are discussed.
The Liverpool Visual Assessment Team (VAT) was established in 1975 as a multidisciplinary service for the evaluation of the disabilities of visually handicapped children. Team membership and patterns of practice are described. Two hundred and fifty-four children have now been seen by the VAT over a 10-year period. The mean age of referral was 4.2 years; only 46% of the children had an isolated visual handicap. The aetiology of disabilities was known in 58% of the children. Genetically determined visual handicap was likely to be associated with normal intelligence. Ophthalmological diagnoses are described. In comparison to what would be predicted, there were fewer children with retinopathy of prematurity and more with cerebral (cortical) blindness. The educational needs and placements of the children are described and the implications of the implementation of the 1981 Education Act for visually handicapped children are discussed.