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Biomedical subjects

L Rosenbloom

Publications and source records attributed to L Rosenbloom.

At least 37 records · Page 2Linked to original sources
PubMed1988

Cerebral palsy in low-birthweight infants. I. Spastic hemiplegia: associations with intrapartum stress.

Children with and without spastic hemiplegia were identified among a representative sample of 1048 low-birthweight survivors by clinical assessment after three years of age. The hypothesis that hemiplegia was predetermined at birth was tested by estimating the probability of hemiplegia for each infant by logistic regression analysis, using data from hospital records on conditions known at the time of birth. 16 of 42 children with cerebral palsy had spastic hemiplegia. Allowing for the lower birthweights of hemiplegic children, increased prevalence was associated with previous reproductive loss, breech vaginal delivery, later birth-order, prolonged second stage of delivery, emergency caesarean section, and low Apgar scores. These variables identified correctly most children as having a higher or lower estimated probability of hemiplegia. Hemiplegia was also associated with prolonged respiratory disease and intraventricular haemorrhage. In this population it is likely that intrapartum events were closely related to the pathogenesis of hemiplegia; their effects may have been mediated by postnatal events.

Cerebral Palsy↗
PubMed1988

Cerebral palsy in low-birthweight infants. II. Spastic diplegia: associations with fetal immaturity.

Twenty children with spastic diplegia were identified by clinical assessment among a representative cohort of 1048 survivors with a birthweight of 2000g or less. Data from hospital case-records were used to investigate which perinatal conditions might differentiate infants with diplegia from other low-birthweight survivors. Even allowing for a strong association with lower gestational age, diplegic children were more likely to have suffered respiratory disease, necrotising enterocolitis and fits in the neonatal period, than children without cerebral palsy. Among preterm infants, diplegia differed from hemiplegia mainly in a lack of significant association with recorded maternal characteristics and markers of intrapartum stress. Important determinants of diplegia were not identified, but the results suggest that infants born both immature and relatively immature for their gestational age have the highest risk of diplegia. Factors that influence the rate of fetal development may be implicated in the aetiology of diplegia in both preterm and fullterm infants.

Cerebral Palsy↗
PubMed1988

Cerebral palsy: a 1987 perspective.

Changing views on reaching a diagnosis, methods of assessment, and management are apparent for neurological disorders in general, and cerebral palsy in particular. A personal approach to the problems associated with the evaluation and care of children and young people with cerebral palsy is outlined, with particular emphasis on the contributions form, and optimal use of, the multidisciplinary assessment team.

Adolescent↗
PubMed1987

Non-convulsive status epilepticus.

Status epilepticus can complicate any type of seizure activity. A group of 13 children with non-convulsive status has been studied. Five presented with chronic fluctuating neurological features, while eight had intermittent episodes of their atypical status, although each of these lasted for several days. The clinical features, treatment, and outcome for these groups of children are described. Most of the children in both groups are mentally retarded after regressing at the time of their status epilepticus. The recognition and aggressive treatment of atypical status is important in reducing the risk of subsequent mental handicap.

Anticonvulsants↗
PubMed1987

Effects of birth weight, gestational age, and maternal obstetric history on birth prevalence of cerebral palsy.

A register of children with cerebral palsy born to mothers resident in the Mersey region from 1966 to 1977 was compiled from health service records. Frequency distributions and prevalences of birth weight and gestational age differed for those with hemiplegia, diplegia, and quadriplegia. In particular, the children with diplegia showed a bimodal frequency distribution. Children of normal birth weight with diplegia had a higher prevalence of severe mental retardation than those of low birth weight. These differences may be due to survival bias and may not be of aetiological importance. Furthermore, the mothers of diplegic infants had a significantly higher proportion of spontaneous abortions, stillbirths, and low birthweight infants in their obstetric history. This suggests that prenatal factors predominate in the aetiology of diplegia.

Abortion, Spontaneous↗
PubMed1986

Disintegrative psychosis of childhood: teenage follow-up.

Nine patients with disintegrative psychosis of childhood were reviewed after follow-up periods of 11 to 16 years. Eight of the nine had a uniform picture of early normal development for two years or more, followed by subacute regression over a period of a few months, to become functionally severely retarded with autistic behavioural features and overactivity. Neurological investigations were consistently negative. The clinical course has remained largely static for these patients, but two have developed epilepsy. They are likely to remain severely handicapped, but not to deteriorate. It is possible that this remarkably homogeneous clinical picture is the result of unidentified encephalopathic processes occurring during early childhood.

Adolescent↗
PubMed1986

Familial cerebral palsy associated with normal intelligence.

We describe two families affected by a recessively transmitted familial cerebral palsy with onset in infancy. Two sisters in the first family have a severe spastic diplegia. The older sister also has mild mental retardation and hypothyroidism whilst the younger sister is of normal intelligence. Two brothers in the second family have a spastic quadriparesis, fifth finger camptodactyly and normal intelligence.

Adolescent↗
PubMed1983

Intervention in child abuse: experience in Liverpool.

The subsequent life events and development of 50 abused Liverpool children who had been removed from their parents and taken into the care of the Local Authority have been determined. Information was obtained by interviewing the district social worker responsible for each child's supervision. Medical progress and school performance was assessed in each case. Following their period in care, 26 children have had an unsatisfactory outcome indicated by the presence, either alone or in combination, of abnormal physical development, emotional disturbance, poor educational progress and occurrence of further abuse. Rehabilitation at home after varying periods of time was attempted for 25 children, five of whom suffered further abuse. The prognosis was worse the older the child on reception into care and the more placements while in care. The children who best survived their experiences after being taken into care were those for whom an early decision was made to sever parental contact and to place the child permanently with a substitute family.

Adolescent↗