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Biomedical subjects

L Puig

Publications and source records attributed to L Puig.

At least 127 records · Page 7Linked to original sources

Plateletpheresis: a comparative study of six different protocols.

Six different protocols were employed in 710 plateletpheresis employing Haemonetics 30, Fenwal CS-3000, IBM 2997 dual stage channel, IBM 2997 single-stage channel, and Haemonetics V-50 "surge pump" method. When Haemonetics 30 and IBM 2997 single-stage channel procedures were used, 5.4 to 5.9 X 10(11) platelets were collected with significant leukocyte contamination (10.8 to 11.6 X 10(9)). With Fenwal CS-3000, dual-stage channel of IBM 2997 and Haemonetics V-50 "surge pump" there was less leukocyte contamination in concentrates (0.3 to 0.9 X 10(9)) as well as a lower platelet yield (3.4 to 4.3 X 10(11)). No difference in yield was observed when plateletpheresis was performed with ACD-A or ACD-B employing the single-stage channel of IBM 2997. Paresthesias was the most frequently seen side effect in donors, with a higher incidence when using ACD-A and IBM 2997.

Blood Component Removal↗

Granulation tissue proliferation during isotretinoin treatment.

Excessive, pseudotumoral granulation tissue proliferations appeared in three patients receiving isotretinoin for nodulocystic acne. A review of the literature disclosed few reports of this unusual adverse reaction. Two clinical patterns have been reported; one in a periungual location and the other occurring in the sites of acne lesions during isotretinoin therapy. Loose edematous connective tissue with small vessels and chronic inflammatory infiltrate were the histologic findings in all three cases.

Acne Vulgaris↗

Infiltrating angiolipoma: report of two cases and review of the literature.

Infiltrating angiolipoma is an infrequent cutaneous tumor, with skeletal muscle infiltration that should be differentiated from the common encapsulated angiolipoma. We present two cases in young women, and review the literature. Infiltrating angiolipoma may be a locally aggressive neoplasm, which makes its clinicopathologic recognition and appropriate therapy important.

Adult↗

Cutaneous angiomas in POEMS syndrome.

POEMS syndrome is an unusual plasma cell dyscrasia with multisystemic manifestations featuring polyneuropathy, organomegaly, endocrinopathy, M protein and constant skin involvement. We have seen a 58-year-old white man presenting with generalized eruptive angiomas as a rare skin manifestation of this syndrome. We review the literature and discuss the pathogenesis of vascular proliferation in this unusual entity.

Cardiomegaly↗

Multiple fibrofolliculomas and trichodiscomas.

A late-onset, sporadic case of multiple fibrofolliculomas and trichodiscomas is reported. This case and other reports in the literature suggest to the authors that benign neoplasms derived from the mesodermal component of the pilar apparatus may present in various combinations and may also be associated with other hamartomatous skin proliferations. The wide spectrum of published combinations may be due to similarities in clinical presentation and biopsy-sampling uncertainties.

Hair Diseases↗

Adverse effects secondary to the treatment with plasma exchange.

Side effects and their relationship with the material used were analyzed in 748 plasma exchanges (PE) performed in 75 patients. The total incidence of acute and mild adverse effects (chills and/or fever, paraesthesias, allergic reactions, acute anaemia, vasovagal reactions, abdominal pain and hypotension) was 18.04%. Two patients developed an episode of left cardiac insufficiency. One patient in whom all PE were performed with fresh frozen plasma (FFP) developed metabolic alkalosis. Three patients developed sepsis during treatment with repeated PE and immunosuppressive drugs; in these three patients a permanent vascular inlet was used (shunt or catheter). All patients in whom only FFP was used as replacement solution developed non-A, non-B hepatitis. Neither haemorrhagic nor thrombotic episodes were observed in these patients. It is of the greatest importance to choose the most suitable material for each patient and to develop a careful technique in order to avoid these complications during treatment with PE.

Abdomen↗