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Biomedical subjects

L Missotten

Publications and source records attributed to L Missotten.

At least 145 records · Page 8Linked to original sources
PubMed1985

Ocular penetration of (125I)IVDU, a radiolabeled analogue of bromovinyldeoxyuridine.

Following topical application of (125)IVDU, the radiolabeled analogue of bromovinyldeoxyuridine ([E]-5-[2-bromovinyl]-2'-deoxyuridine), as 0.5% or 0.3% eyedrops, to rabbits, (125I)IVDU appeared in the anterior chamber fluid at drug levels well above the minimum concentration (0.01 microgram/mL) required for inhibition of herpes simplex virus type 1 replication. These findings are consistent with the efficacy of 0.5% bromovinyldeoxyuridine eyedrops in the topical treatment of herpes simplex uveitis.

Animals↗
PubMed1984

Synaptic contacts between bipolar and photoreceptor cells in the retina of Callionymus lyra L.

A combined light and electron microscopic study of Golgi-impregnated retinas of the marine teleost Callionymus lyra L. revealed mixed bipolar cells (M types) contacting rods and cones and pure cone bipolar cells (C types). Five types of mixed bipolar cells can be differentiated on the basis of their synaptic contacts. Two out of the five mixed bipolar cell types contact double cones, single cones, and rods (mixed, dark, pale, single [Mdps and midget-Mdps]). Their endbuds make narrow cleft junctions, with each type of photoreceptor, and in addition, two endbuds end centrally in the synaptic ribbon complexes of the dark and pale double-cone pedicles. Three types of mixed bipolar cells contact only double cones and rods. The endbuds of one type (mixed, dark, pale, ribbon [Mdpr]) end centrally in the synaptic ribbon complexes of the dark and pale double-cone pedicles as well as of the rod spherules. The endbuds of two types (Mdp and midget-Mdp) make wide cleft junctions in dark and pale double-cone pedicles and in rod spherules. All pure cone bipolar cell types contact cones exclusively with narrow cleft junctions. Four types are seen: a type that contacts predominantly pale double-cone pedicles but also a few dark double-cone pedicles (Cp), a type that is connected with dark and pale double-cone pedicles in about equal numbers (Cdp), a type that makes synaptic contacts with pale double-cone pedicles and single-cone pedicles (Cps), and a type that is connected with both types of double cones and to single-cone pedicles (Cdps). A resemblance between the ultrastructural features of mixed bipolar cell synapses in Callionymus and in Carassius auratus is noted.

Animals↗
PubMed1984

Efficacy of bromovinyldeoxyuridine in the treatment of herpes simplex virus and varicella-zoster virus eye infections.

As has been established in rabbits, (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) is superior to 5-iodo-2'-deoxyuridine (IDU) in the topical treatment of epithelial HSV-1 (herpes simplex virus type 1) keratitis, and superior to 5-trifluoromethyl-2'-deoxyuridine (TFT) in the topical treatment of deep stromal HSV-1 keratitis and HSV-1 uveitis. BVDU 0.1% eye drops have also proven efficacious in the treatment of patients with dendritic corneal ulcers, geographic corneal ulcers and stromal keratitis, and combined treatment of BVDU 0.1% eye drops with oral BVDU at 375 mg/day for 5 days led to a prompt healing of keratouveitis and skin lesions in patients with ophthalmic herpes zoster.

Animals↗
PubMed1983

Corneal epithelial dysplasia after trifluridine use.

Prolonged topical trifluridine treatment of herpes simplex keratitis in three elderly patients produced slightly raised dysplastic corneal epithelial lesions. The involved epithelium had a ground-glass appearance and exhibited opaque cells, edema, and spindle-shaped surface cells. Histopathology demonstrated severe cellular atypism, loss of cell polarity, dyskeratosis, parakeratosis, and a few mitotic figures. The pathological change was apparently intraepithelial. After scraping, the edema and opaque cells in the regenerated epithelium gradually disappeared in 3-4 months on cessation of trifluridine therapy. In one patient recurrence of dendritic keratitis, 5 weeks after scraping, was treated by topical bromovinyldeoxyuridine eye drops. Since severe epithelial dysplasia may represent a precancerous condition, prolonged use of trifluridine should be avoided.

Age Factors↗
PubMed1983

Stratification and square pattern arrangements in the dorsal inner plexiform layer in the retina of Callionymus lyra L.

The dorsal inner plexiform layer in the retina of Callionymus lyra consists of successive fibrous F layers and geometrically organized P layers. In the F layers no pattern arrangement of the bipolar synaptic buttons was observed. In the P layers, on the contrary, the bipolar synaptic buttons are grouped by three distinct square patterns. The alpha pattern measures 5 micron and corresponds to the square pattern of the photoreceptor cells. The beta and the gamma pattern measure 7 micron. One of both patterns corresponds to the single cone arrangement, while the other coincides with the crossings of the rows of double cone pairs. The alternation of F and P layers results in the stratified appearance of the inner plexiform layer.

Animals↗
PubMed1983

Interbipolar contacts in the dorsal inner plexiform layer in the retina of Callionymus lyra L.

Several types of direct contacts have been observed between the square pattern-arranged bipolar synaptic buttons in the P layers in the dorsal inner plexiform layer of the Callionymus retina. These contacts are not randomly occurring interconnections, but they are systematically formed throughout the whole of the dorsal retinal zone and they may be the site of direct synaptic interactions between similar as well as dissimilar bipolar axons. Reciprocal ribbon synapses have been found in the P2,2 layer. Morphologically mixed synapses occur in the P5,1 layer. These contact zones show morphologic characteristics of both chemical and electronic synapses. Morphologically mixed synaptic complexes, representing a triple coupling between two adjacent similar bipolar buttons and an amacrine cell process, have been observed in the P1,1, the P2,1 and the P5,2 layer. The morphology of the interbipolar contacts in the P3,2 layer does not clearly point to a synaptic function. Our results suggest a high degree of functional stratification in the inner plexiform layer.

Animals↗