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Biomedical subjects

L Massimo

Publications and source records attributed to L Massimo.

114 records · Page 7Linked to original sources
PubMedDate not supplied

[Cystic lymphangioma of the spleen (author's transl)].

The spleen is the least common intra-abdominal site for the development of cystic disease. A lymphoangioma of the spleen was first reported in 1885 by Fink; since that time 47 cases of lymphoangioma or lymphoangectasia have been reported. This report concern a case of cystic lymphoangioma of the spleen consisting of a large splenic cyst with associated multiple small subcapsular cysts and lymphangectasia. The diagnosis and treatment of splenic cysts are discussed and a new classification of splenic cysts is proposed.

Child↗
PubMedDate not supplied

[Sepsis related to a permanent central venous catheter in children with neoplastic disease: practical implications of a continuous surveillance of the etiology].

Indwelling central venous catheter-related bacteremias are an important complication in patients with cancer. In general they are due to Staphylococcus aureus and Candida, while bacteremias caused by Gram-negatives are less common and often related to infusate contaminans. We describe a survey of etiological surveillance of Broviac catheter-related infections at G. Gaslini Children's Hospital of Genoa, Italy. In the period 1989-1992 an increase of Broviac catheter-related bacteremias due to Gram-negatives was demonstrated as compared with previous years (1985-1988). At home parental management was suspected as an important risk factor, since this complication was frequently due to infusate contaminants and no epidemic cluster or positive surveillance culture was observed in the Hospital. Therefore at home management was changed, especially regarding heparin storage. The subsequent, prospective follow-up from July 1993 to December 1995 showed a significant decrease in catheter-related bacteremias due to Gram-negatives (P = 0.003, chi-square test). In conclusion, a strict control on at home catheter management procedures must be maintained in order to reduce the risk of indwelling central venous catheter-related infections in children with cancer.

Bacteremia↗
PubMedDate not supplied

[Leukemia in pediatric age].

The prognosis for children with leukemia has improved dramatically in the last 20 years based on prospective clinical investigations of best choice and scheduling of combinations of several agents, considering the risk factors of each patient. The authors review childhood leukemia with respect to epidemiology, classification, laboratory findings (including studies of morphology, cytochemistry, immunologic surface markers, biochemical cytoplasmic markers, cytogenetics with the most frequent chromosome anomalies, molecular biology, immunoglobulin gene and T cell receptor gene rearrangements), clinical manifestations, differential diagnosis, prognostic factors treatment. In respect of patients, it is actually followed the concept of a "total therapy", which includes the purpose the eradicate the invading leukemic cells preserving the expression of normal progenitors, and the psychological and social aspects. The authors consider the clinical trials, the role of bone marrow transplantation (BMT), the supportive care, the evaluation of the minimal residual disease, the study of sequelae and late effects in the survivors, the ethical aspects.

Chromosome Aberrations↗