[Relations between chromosome anomalities and variations in immunity reactions].
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Biomedical subjects
Publications and source records attributed to L Massimo.
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G.L.D. is a rare syndrome characterized by chylothorax, chylous ascites and lymphedema associated to minor symptoms following from lymphangiectasis or to lymphangiomatosis. This syndrome is caused by congenital dysplasia of lymphatic vessels and has, generally, an extremely severe prognosis. In the present papers the authors describe one case of G.L.D. in a six months old infant with chylous ascites, chylothorax, lymphedema, hemangioma and a history of fetal ascites. The preservative (dietetic and evacuative) therapy was not resolutive, therefore an exploratory laparotomy was necessary, but no surgical solution was possible because of the absence of chylous vessels in the anatomical region of the principal lymphatic route. However, laparatomy led to a progressive recovery of ascites and chylothorax, probably due to thrombosis of dysplasic lymph vessels and to neoformation of collateral circulation.
Four subjects, three males and one female, suffering from Kawasaki disease, were studied clinically, immunologically and instrumentally since from the early stages of the disease through 6-10 months. According to data reported in the literature, all the patients showed marked immunological disorders. Microaneurysms of coronary vessels were detected by echocardiography in one of the patients; such finding, constantly present through the follow-up, did not have any clinical and/or electrocardiographic correlate. Moreover, it is worth recording the rapid remission in all subjects of the principal clinical and humoral systems following the treatment with ASA + high dosage Ig given via intravenous.
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