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Biomedical subjects

L Levi

Publications and source records attributed to L Levi.

At least 109 records · Page 6Linked to original sources
PubMed1975

Circadian rhythms of catecholamine excretion, shooting range performance and self-ratings of fatigue during sleep deprivation.

Circadian rhythms in urinary catecholamine excretion, performance and self-ratings were studied in two experiments with a total of 29 subjects who were deprived of sleep for 72 hr. Adrenaline excretion and fatigue ratings showed the most consistent circadian variations; noradrenaline and performance rhythms were more irregular. The average crest phase for adrenaline excretion was around 1400 hr, for noradrenaline about 0800 hr, for performance 1700 hr and for fatigue 0500 hr. Twenty-four hour levels of performance and 'subjective arousal' decreased over the three days of sleep deprivation, while adrenaline excretion levels increased.

Adult↗
PubMed1975

Ibuprofen versus buffered phenylbutazone in the treatment of osteoarthritis: double-blind trial.

In a double-blind multiclinic trial, a new nonsteroidal anti-inflammatory agent (ibuprofen) was compared with an established therapeutic agent (phenylbutazone-alka) for the treatment of osteoarthritis. Of the 159 patients from the 17 contributing clinics, 144 completed the four weeks of therapy. More than 60 per cent of them reported improvement in exercise-related pain by week 4, and there was no significant difference between treatment groups. The patients' and the physicians' evaluations of the total state of disease, as well as range-of-motion and functional tests, demonstrated similar degrees of improvement in both treatment groups. The incidence of side effects was within acceptable limits, and the frequency distribution was similar in both groups. Of the 70 reported side effects, 29 were considered by the investigator (blind trial) to be drug-related-11 in association with ibuprofen and 18 with phenylbutazone-alka. Hematologic and blood chemical studies, as well as urine and stool examinations, yielded normal results with the exception of a reduced mean value for serum uric acid and a slightly elevated mean value for SGPT in the phenylbutazone-alka group.

Alanine Transaminase↗
PubMed1968

Plasma lipids and urinary excretion of catecholamines in man during experimentally induced emotional stress, and their modification by nicotinic acid.

33 male volunteers were studied in the morning after fasting overnight. 11 (the control group) were allowed to sit comfortably for three consecutive 2-hr periods, no stressors or treatment being introduced. The remaining 22 were divided into two groups, each being exposed to standardized, emotional stressors during the second of the three 2-hr periods. The subjects in one of these groups were each given a total dose of 3 g of nicotinic acid during the first 3 hr of the experiment, whereas the other group received no treatment. Stress was accompanied and followed by increased levels of free fatty acids and triglycerides in arterial plasma, by an increase in catecholamine excretion, and a rise in heart rate and systolic and diastolic blood pressure. No such increases were seen in the control group. The stress-induced rise in free fatty acids was inhibited by nicotinic acid, and the triglyceride rise was turned into a fall. The stressor-induced increase in catecholamine excretion was not significantly affected by nicotinic acid, neither were the increases in heart rate and blood pressure. The hypothesis is discussed, from a qualitative as well as a quantitative viewpoint, that there is a direct relationship between the increased concentration of free fatty acids accompanying emotional stress in man and the eventual development of the stress hyperlipoproteinemia.

Adipose Tissue↗