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Biomedical subjects

L Laroche

Publications and source records attributed to L Laroche.

At least 217 records · Page 12Linked to original sources
PubMed1984

[Retinal vasculitis in systemic lupus erythematosus].

The authors report three patients with systemic lupus erythematosus (S.L.E.) who developed primary retinal vasculitis. All patients showed evidence of four American Rheumatism Association diagnostic criteria for S.L.E. The first case consisted of a woman with retinal central vein occlusion. Auto-immunization against retinal S antigen was present. She improved under heparin therapy. In the second case, a young girl had chronic optic disk vasculitis for seven years. In the third case, retinal arterial occlusive disease was present with optic nerve involvement. The differential diagnosis with multiple sclerosis is discussed. S.L.E. is considered as autoimmune disease where circulating immune complexes play a major role in the pathogenesis. The ocular complications are probably a manifestation of the widespread systemic disease in patients without arterial hypertension. The authors summarize the ocular findings in S.L.E.: venous obstruction, constriction of retinal arteries, capillary vasculitis and disc neuritis. In some cases, there may be the first manifestations of the disease.

Adolescent↗
PubMed1983

[The role of evoked potentials in the diagnosis of multiple sclerosis].

Diagnosis of multiple sclerosis is based mainly upon evidence of inflammation in the cerebrospinal fluid and of diffuse neurological involvement. The second feature is often lacking at onset. It is important to establish the diagnosis as early as possible. In this respect, evoked potentials (visual, auditive or somatosensory) in the brainstem are useful to demonstrate asymptomatic lesions. Our recordings taken in 43 patients are conclusive. The diagnostic reliability of simultaneous recordings of all three types of evoked potentials is similar to that of the study of cerebrospinal fluid.

Evoked Potentials↗
PubMed1983

Ocular findings following intravitreal silicone injection.

In three cases of intraocular silicone oil injection in which the histologic picture is observed at different time intervals, emphasis is given to the fact that fibrous tissue formation around silicone vesicles is a rather constant complication and of early occurrence. Thus, we believe that the removal of liquid silicone from the eye should not take place later than two or three months after the injection. In our first reported case, there was an association of silicone oil injection and vitrectomy with retinal detachment procedures and sympathetic ophthalmia. In the absence of evident histologic or clinical proof, we do not consider silicone oil injection itself as having induced the mechanisms of sympathetic ophthalmia.

Adolescent↗
PubMed1983

Immunological characterization of an ocular adnexal lymphoid T tumor by monoclonal antibodies.

The phenotype of a lymphoid orbital tumor is described, using monoclonal antibodies of the OKT series. The majority of tumor cells lacked surface immunoglobulins and bound OKT3, hence they arose from the T lineage. These cells belonged to the mature helper T cell subpopulation since a great proportion was recognized by OKT4 antibody. In contrast, a decrease in the peripheral blood OKT4+ pool was observed. The results demonstrate the importance of using a panel of markers, such as monoclonal antibodies, for the identification of cell derivation of lymphomas.

Aged↗
PubMed1983

Sezary syndrome. I. Specific skin-directed migration of peripheral blood lymphocytes.

The in vitro migration of peripheral blood lymphocytes (PBL) from Sezary syndrome (SS) patients and from controls was studied using a migration assay under agar. Only PBL from SS patients migrate to normal allogeneic skin. This migration is organ specific. It requires the integrity of lymphocyte membrane receptors. Serum factors are not involved. Studies of the nature of these migrating lymphocytes using monoclonal antibodies suggest that they belong to a subset of helper T cells. These data indicate a functional impairment of SS lymphocytes, which enables them to respond to a skin-derived signal.

Blood Physiological Phenomena↗
PubMed1983

[Retinal arteritis in Liebow's lymphomatoid granulomatosis].

A case is reported of central retinal artery obstruction appearing during the course of a Liebow lymphomatoid granulomatosis. Extrapulmonary manifestations of this necrotizing angiitis, and the differential diagnosis with Wegener's granulomatosis are discussed.

Adult↗
PubMed1983

[Acute insufficiency of the chorioretinal circulation].

This is a study of 6 cases of sudden drop in visual acuity manifested by a central scotoma. Fundus examination showed ischemic oedema of the posterior pole and in 3 cases the presence of cotton wool bodies. Fluorescein angiography shows a constant delay in choroidal injection associated or not with a delay in central retinal arterial injection. All these patients have carotid artery circulatory insufficiency. We present a discussion of the pathogenesis, the possible role played by choroidal artery obstruction in the macular injury.

Adult↗
PubMed1983

[Sympathetic ophthalmia and microsurgery of the posterior segment].

Clinical, angiographic and histologic findings in a case of sympathetic ophthalmia are reported. There was a time interval of two years between injury and onset of symptoms of sympathetic ophthalmia. The incidence of sympathetic ophthalmia after posterior segment surgery is discussed. The risk is low (0.01 p. cent) when vitrectomy is performed in the absence of ocular wounds, but increases for complex and repeated surgical procedures (0.16 p. cent).

Fluorescein Angiography↗