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Biomedical subjects

L L Wilson

Publications and source records attributed to L L Wilson.

At least 55 records · Page 3Linked to original sources
PubMed1980

Histologic evaluation of the effects of diethylstilbesterol and zeranol on certain lamb tissues.

Forty-eight lambs with equal numbers of rams, ewes, and wethers were used in a growth and metabolism trial. Within each sex, equal numbers were used as controls, and implanted with zeranol or deithylstillbestrol (DES) or both. The lambs were slaughtered 44 days after implanting and the effects of the different implants (or in combination) on certain endocrine glands, urogenital tracts, and other selected tissues were determined. All animals given implants had adrenal cortical hyperplasia. Thyroid gland activity was depressed by DES implants in wethers, and by the combination of zeranol and DES in wethers and rams. Changes in the urogenital tracts of DES-implanted lambs, including the urethra, seminal vesicle, epididymis, testis, and uterus, were similar to those observed following treatment with exogenous estrogens. The results of this evaluation confirm that DES has higher estrogenic activity than zeranol. When these two compounds were used in combination, their estrogenic effects were additive.

Adrenal Glands↗
PubMed1980

Environmental and genetic effects on hematologic characteristics of beef cows.

The objective of this study was to determine the effects of certain environmental and genetic factors on selected hematologic characteristics of beef cows under wintering and grazing conditions in the Northeast. Packed cell volume PCV, hemoglobin concentration (Hb), RBC count, and WBC count were determined in serial blood samples collected periodically during 1976 from 24 young and mature, gestating and lactating, Angus and Angus-Charolais cows. The PCV, Hb, and RBC were significantly correlated (P < 0.001, n = 257; rPCV . Hb = 0.89, rPCV. RBC = 0.74, rHb . RBC = 0.72). Lactating cows grazing mixed swards containing 24% legume had higher (P < 0.001) PCV and Hb than did cows grazing all-grass swards fertilized with 168 kg of nitrogen/ha. The RBC was higher (P < 0.01) in cows grazing all-grass swards, whereas no differences in WBC were observed between groups. Angus cows had lower PCV (P < 0.001) and RBC (P < 0.005) than did Angus-Charolais cows. Individual cows of identical physiologic maturity-breed-diet groups differed (P < 0.05) in PCV, Hb, RBC, and WBC, indicating that there are repeatable differences in these traits among individual cows. Significant effects of season and physiologic state (pregnancy vs lactation) were observed for PCV, Hb, RBC, and WBC (P < 0.01).

Animal Feed↗
PubMed1979

Remler recorder.

Explore the source record for details and available documents.

Australia↗
PubMed1976

Clinical and haemodynamic effects of minoxidil in refractory hypertension.

Thirteen patients whose hypertension had been resistant to conventional drug therapy, had minoxidil added to their regimen in doses from 5 to 60 mg/day. All responded with satisfactory reductions of blood pressure to mean values of 149/90mm Hg (supine) and 143/89mm Hg (standing). A significant portion of their previous antihypertensive therapy was either greatly decreased or withdrawn completely. Although fluid retention occurred in most patients as the dose of minoxidil was increased, this could be successfully checked by the use of diuretics. It was considered that in addition to beta-adrenoreceptor blocking drugs to control the reflexly induced cardiac stimulation, sufficiently aggressive diuretic therapy is mandatory to ensure the successful use of this drug. Haemodynamic evaluations in seven patients clearly showed that lowering of blood pressure was the result of decreases in peripheral vascular resistance as significant increases in the cardiac index occurred in all patients.

Adult↗
PubMed1975

Pathologie changes in endocrine glands and certain other tissues of lambs implanted with the synthetic growth promotant zeranol.

As doses of zeranol implants (0 (control), 12, 24, 48, and 96 mg) were increased, there were increased reaction and activity in target organs (such as urogenital tract and mammary, adrenal, hypophyseal, and thyroid glands) of castrated male sheep (wethers). Hyperplasia and transitional and squamous transformation in the prostate were mild (1+) in the wethers given 12- and 24-mg doses, moderate to marked (2.5+) in the wethers given 48-mg doses, and severe (4+) in the wethers given 96-mg doses. Papillary proliferation and fibrosis increased correspondingly in the seminal vesicle. Changes in the distal penile urethra increased from papillary hyperplasia in the wethers given a 24-mg dose to 100% squamous transformation in the wethers given a 96-mg dose. Mammary gland development was noticeable in the wethers given a 24-mg dose and increased thereafter to progressive alveolar growth and secretory activity in the wethers given 48- and 96-mg doses. Along with a progressive increase of adrenal gland weight and adrenal gland/thyroid gland ratios over the controls, the principals had hypertrophy and hyperplasia of the adrenal cortex. Mean adrenal cortex widths for control wethers and wethers given 24-, 48-, and 96-mg doses were 2,089, 2,140 (adjusted value, 2,194), 2,416, and 2,425 mum, respectively. Mean adrenal gland weights for control wethers and wethers given 12-, 24-, 48-, and 96-mg doses were 2.50, 2.61, 2.53, 2.70, and 2.78 g. respectively. Hyperplasia (nodule formation) plus exhaustive and pyknotic changes of the adrenal cortex increased similarly with increasing zeranol dose. After the thyroid gland weights decreased (2.19, 2.04, 2.00, and 1.72 g, respectively, for control wethers and wethers given 12-, 48-, and 96-mg doses), secretory activity of thyroid epithelial cells decreased. In the glandular portion of the hypophysis, secretory activity and proliferation of eosinophilic cells increased with the larger zeranol doses (48 and 96 mg). There was a corresponding decrease in the number of basophils. These changes are consistent with increased somatotropin and adrenocorticotropin secretion and decreased thyrotropin secretion. Muscle and ligament structures appeared looser and widened in the wethers given the 96-mg dose, and fat cell formation was increased in the muscles along ligament muscle junctions.

Animals↗