Biomedical subjects
Publications and source records attributed to L L Smith.
Hb-Manitoba was discovered in 1970 [1] in a Canadian family of British origin. Recently we observed the same variant in a second family, and found that the oxy-derivative of Hb-Manitoba is slightly unstable at 65 degrees C, dissociates less readily at alkaline pH than does Hb-A, and forms asymmetric hybrids with other hemoglobins which are readily detectable by electrophoresis.
Two patients with spontaneous aortocaval fistulas are described and compared with 67 cases reported in the English literature. Symptoms may vary widely; however, the presence of an expansile abdominal mass with a continuous bruit is usually diagnostic. The only successful management is promt repair of the vena caval defect and the aortic aneurysm. A third patient with spontaneous rupture of an abdominal aortic aneurysm into the left renal vein is alos described. Only five similar cases could be found in the work literature. Left flank pain, pulsatile abdominal mass, continuous bruit, and hematuria is the usual clinical picture. All of these cases involved an anomalous left retroaortic renal vein and all patients survived the necessary surgical correction. The operation of choice is closure of the defect in the retroaortic left renal vein and repair of the aneurysm.
The facile acid-catalyzed conversion of cholest-5-ene-3 beta, 7 alpha-diol (but not of cholest-5-ene-3 beta, 7 beta-diol) in methanol or ethanol solution to the corresponding 7 alpha-methyl or 7 alpha-ethyl ethers and epimerization of the 7 alpha-alkyl ethers to the corresponding 7 beta-alkyl ethers were established. The epimeric cholest-5-ene-3 beta, 7-diols, their 7-methyl ethers, and their 7-ethyl ethers are readily interconverted in acidified solvents, the quasiequatorial 7 beta-epimer predominating in each case. Both 7 alpha- and 7 beta-alkyl ethers may be encountered as artifacts in analyses of sterol mixtures from mamalian tissues.
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The volatile fragments of air-aged cholesterol were analysed by means of gas chromatography-mass spectrometry; The following fourteen compounds were identified: ethanol, acetic acid, acetone, 2-methylpropene, 2-methyl-1-propanol, 2-methyl-2-propanol, 2-butanone, 2-methylpropionic acid, 2-methyl-2-butanol, 2-pentanone, 3-methyl-2-butanone, 2-methyl-1-pentene, 2-methyl-2-pentanol, and 2-methyl-4-penten-2-ol. Their formation via decomposition of initially formed sterol hydroperoxides is discussed.
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The bioassay for erythropoietin-stimulating factor (ESF) was compared in 3 strains of mice. One strain was made polycythemic by hypertransfusion and the other 2 by hypoxia. An erythropoiesis-generating factor (EGF) measured in the 3 strains generated approximately the same amounts of ESF, determined with log dose-log response curves for the respective techniques, after incubation with normal rabbit serum (NRS). The amount of ESF generated by EGF without prior incubation with NRS was also approximately the same in the 3 strains of mice.
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After oral administration of a lethal dose of paraquat to rats the plasma concentration remained relatively constant over four to 30 hours and was related to the paraquat content of the small intestine over the first 16 hours. During the first 30 hours the concentration of paraquat in the lung rose progressively above that of the plasma to levels which are known to cause pulmonary damage. A treatment has been devised which prevents the absorption of paraquat into the plasma and prevents accumulation of paraquat in the lung. This treatment consists of a stomach was followed by four administrations of bentonite plus purgatives at two- to three-hour intervals. Even when treatment was delayed until 10 hours after administration of paraquat 80% survival was obtained. The relevance of this treatment to paraquat poisoning in man is discussed in the light of the finding that slices of human lung accumulate paraquat in the same way as those of rat lung.
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