Search PubMed⌕ Search

Biomedical subjects

L L Smith

Publications and source records attributed to L L Smith.

At least 235 records · Page 13Linked to original sources
PubMed1977

Social work services for radiation therapy patients and their families.

A social worker helps meet the social and emotional needs of cancer patients undergoing radiation therapy at the University of Utah Medical Center and the needs of their families. He makes personal contact with the patient and family on their first visit to the radiation division, answers questions, provides information on community services, and generally lets the patient and family know that they can call on him any time during the treatment process. He also follows up patients who are still seriously ill after treatment, and tries to maintain periodic contact with families of patients who have died.

Aftercare↗
PubMed1977

Some properties of hemoglobin Gun Hill.

Hb Gun Hill has been found in an asymptomatic black female living in Alabama; neither her parents nor her two siblings carry the variant. The deletion of five amino acid residues in the beta chain of Hb Gun Hill (alpha2beta2 91-95 deleted) causes this variant to have a high oxygen affinity, an interaction coefficient of unity and an absence of the Bohr effect. The rate of oxidation of liganded Hb Gun Hill by the ferricyanide ion follows first-order kinetics. Hb Gun Hill is to a great extent dissociated into dimers over a wide range of pH values.

Adolescent↗
PubMed1977

Gamma heavy chain disease: clinical aspects and characterization of a deleted, noncovalently linked gamma1 heavy chain dimer (BAZ).

This report describes the clinical and immunoglobulin features of a patient with gamma heavy chain disease (HCD), who presented with a clinical picture suggestive of an underlying malignancy rather than the usual picture of lymphoma or granulomatous disease. A unique clinical feature was the nearly total replacement of the submaxillary glands by plasma cells. The patient's serum and urine contained a paraprotein, gammaHCD protein BAZ, which belongs to the gamma1 subclass and forms noncovalently linked dimers with a molecular weight of approximately 60,000 daltons. This mutant protein exhibited a deletion which encompassed most of the variable (V) region, the first constant domain (CH 1), and the hinge region. In addition, preliminary structural analyses demonstrated the replacement of alanine by glycine in position 431 of the carboxyterminal octadecapeptide. This substitution may possibly represent another allotypic marker on IgG1 proteins.

Aged↗
PubMed1976

Blood gas and carotid pressure: factors in stroke risk.

The internal carotid back pressure and arterial blood gas measurements have been employed in 269 patients undergoing 332 carotid endarterectomies in an effort to identify individuals at high risk of stroke during surgery. Patients having an internal carotid back pressure less than 25 Torr were operated using an inlying shunt. There were 159 patients having a PaCO2 greater than 45 Torr, 95 individuals with a PaCO2 between 35 to 45 Torr and 78 cases with a PaCO2 less than 35 Torr. The mean internal carotid back pressure was 63 Torr in the hypocarbic group and 45 Torr in the hypercarbic patients which represents a highly significant inverse relationship between PaCO2 and carotid back pressure (P less than 0.0002). There were four neurological deficits following surgery in the hypercarbic group and one each in the normocarbic and hypocarbic groups. These findings suggest a lower stroke incidence in patients having hypocarbic or normocarbic general anesthesia than those receiving hypercarbic general anesthesia. The low overall stroke rate of 2% indicates the safety of selective shunting during carotid endarterectomy.

Aged↗
PubMed1976

Correlation of neurologic complications and pressure measurements during carotid endarterectomy.

There was no significant difference between the mean occluded internal carotid artery pressure in asymptomatic, transient ischemic attack or prior stroke patients. The stump pressure was not consistently elevated at the second operation in those having undergone bilateral procedures. Estimate of back bleeding from the internal carotid artery operation did not necessarily correlate with the stump pressure. Adequate back bleeding was recorded in patients with a low stump pressure, and reduced bleeding was noted in individuals with a high stump pressure. The pressure gradient across the stenosis of the bifurcation of the carotid artery was helpful in assessing the degree of stenosis present. The occluded internal carotid artery pressure seemed to be a helpful aid in indicating those patients with poor collateral flow and, therefore, at high risk of ischemic brain damage. The use of an inlying shunt in those individuals having a low stump pressure may be expected to reduce the over-all neurologic complication rate in patients undergoing carotid endarterectomy.

Blood Gas Analysis↗