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Biomedical subjects

L Kreel

Publications and source records attributed to L Kreel.

At least 163 records · Page 9Linked to original sources

Computer tomography in the evaluation of pulmonary asbestosis. Preliminary experiences with the EMI general purpose scanner.

Thirteen individuals with varying lengths of exposure to asbestosis were examined by computer tomography with the EMI Scanner. Various pleuroparenchymal abnormalities were found, many not being seen on standard chest films. In some cases, with normal chest radiography, definite pleural involvement could be demonstrated, particularly that in the posterior sulci on the diaphragm and at the mediastinum. Tissue attenuation measurements in regions of parenchymal involvement reached 90 EMI units above normal lung tissue. The normal gravity effect is abolished in cases of parenchymal disease caused by asbestosis. Parenchymal disease was much more obvious on the CT scans than on conventional chest films.

Asbestosis↗

Intralobar septal oedema: 'D' lines.

A combined radiological and autopsy study of pulmonary oedema enables recognition of oedema lines other than Kerley 'A', 'B' and C lines. These have been designated 'D' lines. At least three varieties have been noted: (i) thick, long often angular lines seen mainly anteriorly overlying the heart shadow on the lateral film. These may also appear as horizontal or vertical band shadows, on the frontal view. (ii) Short and straight lines, occurring basally and often slightly thicker at the pleural surface, which on autopsy lung radiographs are associated with puckering of the pleura. They have also been recognised on lateral films where they resemble the pleural end of a fissure but have been seen in positions where fissures do not mormally occur, or in addition to the normal fissure. (iii) A subpleural reticular pattern surrounding spaces 1-2 cm in diameter. This has been noted only on autopsy-inflated lungs and not detected on in vivo chest radiographs. The long 'D' lines or D(i) lines occur in areas where 'B' lines are inconspicuous or absent and vice versa. Whereas 'B' lines are most prominent in areas of macroscopic alveolar pulmonary oedema, D(i) lines occur where macroscopic alveolar pulmonary oedema is often inconspicuous. The recognition that lines other than 'A', B and 'C' occur in case of pulmonary oedema greatly assists in the interpretation and diagnosis of the shadows on chest radiographs associated with pulmonary oedema.

Autopsy↗

Pulmonary oedema at necropsy: a combined pathological and radiological method of study.

Fixation of lungs at necropsy by inflation with formaldehyde vapour was used in a combined radiological and pathological study of pulmonary oedema. Pulmonary oedema was found in 79% of lungs examined. The earliest phases affect the interstitial tissue with oedematous connective tissue planes and distension of pulmonary lymphatics. These changes may be associated with reduction in the compliance of the lung. Alveolar filling is a late stage in the accumulation of oedema fluid in the lungs.

Adult↗

Pharmaco-radiology in barium examinations with special reference to glucagon.

The reasons for and objections to the use of drugs as adjuncts in barium meal and follow-through examinations are briefly reviewed. Physiological factors related to gastric emptying are considered, including the volume, temperature and osmolarity. The drugs considered include those that speed gastric emptying and small bowel transit such as metoclopramide, those that delay gastric emptying such as propantheline and gastrointestinal hormones such as glucagon. Glucagon first produces gastric and duodenal dilatation and subsequently speeds transit through the small bowel. The indications, contra-indications and side effects of these drugs are also considered and tabulated.

Barium Sulfate↗

The Budd-Chiari syndrome: correlation between hepatic scintigraphy and the clinical, radiological, and pathological findings in nineteen cases of hepatic venous outflow obstruction.

From 1965 to 1972, 19 patients with the Budd-Chiari syndrome were investigated. An underlying diagnosis was made in 10 cases, polycythemia rubra vera being the commonest etiology. Percutaneous liver biopsy confirmed the diagnosis in 18 patients, and in 14 the site of hepatic vein obstruction was defined or its presence suggested by hepatic venography. Hepatic scintiscanning showed predominant central localization of radiocolloid in 7 patients. In another 8 patients this appearance was present in association with other less specific features. These findings were correlated with inferior vena cavography in 13 patients in whom a characteristic narrowing and distortion of the vein throughout its intrahepatic course was noted. In 3 other patients, the vein was found to be occluded. Autopsy evidence in 6 patients suggests that the central concentration of radiocolloid on scintiscanning and the narrowing and distortion of the inferior vena cava were due to disproportionate enlargement of the caudate lobe. Additional studies indicated that the separate venous drainage of the caudate lobe may be preserved when the main hepatic veins are occluded and that hypertrophy of the caudate lobe occurs because of its relatively more efficient perfusion. Demonstration of the enlarged caudate lobe by scintiscanning and inferior vena cavography provides valuable diagnostic support for the Budd-Chiari syndrome.

Adult↗

Use of intravenous urography.

Studies on 1,476 intravenous urographic examinations done in a 15-month period showed that the proportion of abnormal results varied widely-from 20% in patients with abdominal pain other than renal colic to 92% of those in prostatism. Patients with the strongest clinical evidence of haematuria were the most likely to have abnormal urograms, and to undergo cystoscopy with abnormal findings on this examination. All six patients with renal hypertension showed abnormalities other than on the urogram. Prior use of other tests may increase the effectiveness of urography.

Abdomen, Acute↗