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Biomedical subjects

L Kisbenedek

Publications and source records attributed to L Kisbenedek.

32 records · Page 2Linked to original sources
PubMed1980

[The value of rectal examination in the diagnosis of prostatic cancer (author's transl)].

Rectal examination is the basic step in the diagnosis of carcinoma of the prostate. However its accuracy is limited because cancerous nodules are often difficult to differentiate from certain benign conditions which cause areas of induration. Needle biopsy is necessary for establishing the diagnosis of cancer. 699 men with palpable lesions of the prostate underwent transperineal biopsy. Out of 251 patients with advanced lesions only 171 (68.1%) had a histologically proved carcinoma of the prostate. Out of 119 men with an isolate firm nodule 50 (42%) had a positive biopsy whereas in only 62 (18.8%) of 267 biopsies of glands with changes in consistency and indurations histological examination confirmed the diagnosis of prostatic carcinoma.

Humans↗
PubMed1977

Buschke-Loewenstein tumour of the penis.

Three cases of Buschke-Loewenstein tumour are reported. The clinical features of the process are described, its therapeutic aspects are outlined, the diagnostic problems involved by its microscopic structure are discussed. The features of the first case were typical of the process. The intermediate form between the Buschke-Loewenstein tumour and squamous cell carcinoma was exemplified by the second case. The small size of the tumour in the third case was compatible with an organ-saving surgical intervention.

Adult↗
PubMed1976

[Transurethral resection of bladder neoplasms].

The technique of removal of bladder tumours is discussed on the basis of experience with transurethral resection performed on 200 patients suffering from bladder tumour (113 benign and 87 malignant tumours). The indications for the intervention are as follows. With benign tumours, resection has to be given preference over exposure. When malignant tumours are operable and situated on the mobile part of the bladder, radical surgery is recommended. When the tumour is in some other position, transurethral resection is the procedure of choice.

Female↗
PubMed1975

Treatment of prostatic cancer with Estracyt (estramustine phosphate).

The experience gained with Estracyt, kindly supplied by AB LEO, Sweden, is reported. On the basis of former data in the literature we only used the drug in estrogen resistant and advanced cases. Estracyt (estramustine phosphate) is a nitrogen mustard derivative of the urethan type, attached to oestradiol-17-phosphate. In histologically verified cases, it was administered in daily doses of 300 mg intravenously for three weeks, followed by maintenance doses of 300 mg a week in tablets for three months. During treatment, liver and bone marrow function was checked systematically. The changes in morphological picture were studied by means of biopsies during and at the end of treatment. In agreement with the data in the literature a favourable effect was observed in estrogen resistant patients, with no toxic effect whatever on the bone marrow. At the same time GOT and GPT and BSP retention examinations demonstrated a hepatotoxic side effect. The pathological values returned to normal after withdrawal of the drug. Histological examinations showed that the tumour cells had changed but failed to disappear after treatment.

Clinical Trials as Topic↗
PubMed1975

Granulomatous orchitis and spermatic granuloma.

One case of granulomatous orchitis and three cases of spermatic granuloma are described and the clinical and pathologic features of the two syndromes are discussed. Since no certain diagnosis is possible on clinical grounds alone, it rests on the evidence of pathology. Both granulomatous orchitis and spermatic granuloma are of practical importance to the specialists, the first being apt to mimic tumours, and the second to tuberculous epididymitis. Histological study, possibly of biopsy specimens, permits to differentiate either process from malignancy and from tuberculosis with certainty. It is to be emphasized that in many cases of chronic epididymitis with clinical suspicion of tuberculosis careful histological search reveals spermatic granuloma. Since the processes under discussion are unresponsive to antibiotics, their therapy is surgical.

Adult↗
PubMed1975

[Resection syndrome following transurethral resection of the prostate].

The essence and clinical aspects of the resection syndrome occurring in association with transuretheral prostate resection and the possiblity of determining the direction of the absorption of the washing solution are discussed. By means of radioisotope tests a direct correlation was detected between the extent of the haemorrhage and the intravasation of the washing solution. Great importance is ascribed to the vesico-renal reflux often occurring during resection, which might have a major role in the development of post-resectional pyelonephritis.

Aged↗