Biomedical subjects

L Janzon

Publications and source records attributed to L Janzon.

205 records · Page 12Linked to original sources

PubMedDate not supplied

The influence of GGT, COHb% and body weight on the 2-h glucose and insulin response after a standardized oral glucose load.

Relative body weight (A/I weight) serum gamma-glutamyl-transferase (GGT) and carboxyhemoglobin (COHb%) were related to glucose and insulin values at 0 and 120 min in a sizable, consecutive series of oral glucose tolerance tests (OGTTs) in middle-aged males. Partial and multiple correlation coefficients were calculated, and the squared stepwise multiple correlation coefficient was used to estimate how much of the variability of glucose and insulin could be accounted for by the three factors. No less than 14% of the glucose variability and 25% of the insulin variability at 2 h could be attributed to them, emphasizing the importance of keeping these three factors in mind when interpreting the results of OGTTs.

Blood Glucose↗

PubMedDate not supplied

Chronic effects of gastroduodenal surgery on glucose and insulin response to oral glucose tolerance test in a population study.

Oral glucose tolerance test (OGTT) results were compared between 4,667 middle-aged males attending a preventive medical screening and intervention program in Malmö and the subjects in this sample who reported a history of previous operation for gastric or duodenal ulcer (n = 158, or 3.4%). 76% of the operated subjects were smokers in comparison with 50% in the general cohort of males of the same age. The glucose and insulin responses in the OGTT in both the smoking and non-smoking operated cases showed higher early peak values and a subsequent rapid drop of the levels with lower 120-min values of both glucose and insulin compared to the average screening cohort. This type of response to an oral glucose load had previously been well known in the acute and immediate postoperative stages of gastric and duodenal resection, but it had not been shown before that it seems to be a permanent effect and may chronically influence the results of OGTTs in the population. Gastro-duodenal surgery should be included among the factors which may significantly affect the chronic results and thereby also the clinical interpretation of the OGTTs in the population.

Blood Glucose↗

PubMedDate not supplied

A comparison of cognitive ability in normotensive and hypertensive 68-year-old men: results from population study "men born in 1914," in Malmö, Sweden.

Hypertension and its consequences on cognition was analyzed using data from the study "Men born in 1914" in Malmö, Sweden, a prospective cohort study of cardiovascular disease. The baseline examinations took place in 1982/83 where 500 men participated in extensive medical and social examinations. A neuropsychological investigation was completed including five standardized cognitive tests. The specific purpose of the study was to investigate whether hypertension was associated with cognitive performance. By the use of multiple regression analyses, normal blood pressure and three stages of hypertension were analyzed in relation to test performance. Hypertension Stage 3 was associated with lower performance on tests measuring psychomotor speed and visuospatial memory, whereas hypertension Stage 1 was associated with higher performance on tests measuring verbal ability and constructional ability. The associations were unconfounded by clinical manifestations of atherosclerosis, history of stroke, depressive mood, and antihypertensive drug treatment.

Aged↗

PubMedDate not supplied

Influence of carboxyhemoglobin, gamma-glutamyl-transferase, body weight, and heart rate on blood pressure in middle-aged men.

Carboxyhemoglobin (COHb%) and gamma-glutamyl-transferase (GGT) are indicators of tobacco and alcohol consumption; similarly, body weight broadly reflects dietary habits. Relationships between COHb%, GGT, relative body weight, heart rate and blood pressure were studied in 242 48-year-old men attending a general health screening program in Malmö, Sweden. All were without treatment for high blood pressure. Positive correlations were found between blood pressure and body weight, GGT, and pulse, and a reciprocal correlation between blood pressure and COHb%. Use of objective markers for known or suspected risk factors, such as alcohol consumption, smoking, or overweight, were studied to elucidate their usefulness for further prospective studies.

Alcohol Drinking↗

PubMedDate not supplied

Survival in breast cancer and age at start of oral contraceptive usage.

In general, findings in studies on oral contraceptives (OCs) and breast cancer have not indicated prognosis to be worse among users of OCs. In few studies, however, has age at the start of OC usage been considered as a prognostic factor. In the present study, prognosis in breast cancer is compared with OC usage, particularly with age at the start of OC usage, among 193 consecutive patients at the Department of Oncology, University Hospital, Lund. An earlier series of 193 breast cancer patients at Malmö General Hospital is included for comparisons. In the Lund series, five-year survival was 62% among women who started to use OCs before the age of 20.78% among those who started to use OCs between the ages of 20 and 25, and 86% among non-users and those who started to use OCs after the age of 25 (p = 0.009, test for homogeneity). Although age was found to be a prognostic factor in the Lund series (RR = 0.90, p = 0.001), this was not so in the earlier (older) Malmö series. The relationship with age differed significantly between the two series (p = 0.003), suggesting the apparent effect of age at diagnosis to be a cohort effect due to the introduction of OCs during the 'sixties. The age-specific relationship between survival and OC usage would seem to indicate the presence of a biological mechanism in which OCs may participate during precancerous and early stages of breast cancer.

Adult↗

PubMedDate not supplied

Relation between aryl hydrocarbon hydroxylase inducibility, serum gamma-glutamyltransferase and serum cholesterol in middle-aged smokers and non-smokers.

Aryl hydrocarbon hydroxylase (AHH) inducibility, carbon monoxide in expired air (CO), serum gammaglutamyl-transferase (GGT), and total cholesterol were compared in equal-sized, age-matched samples of healthy middle-aged males born in 1921, 1934-1936, and 1946 attending the ongoing preventive medical population program in Malmö. AHH did not differ in various age - and smoking or non-smoking groups, and there were no correlations between AHH, GGT, and cholesterol. The findings provide evidence against the recent hypothesis that low cholesterol may mediate or reflect a carcinogenic mechanism through a state of general enzyme induction in the body.

Aryl Hydrocarbon Hydroxylases↗

PubMedDate not supplied

Smoking, carboxyhaemoglobin, carbon monoxide in expired air and aryl hydrocarbon hydroxylase inducibility. A cross-sectional study and anti-smoking applications in middle-aged men.

In this cross-sectional study we report on the distributions of carboxyhaemoglobin in blood (COHb%), carbon monoxide in expired air (CO), and aryl hydrocarbon hydroxylase (AHH) inducibility in age-matched samples of males born 1934-36 and 1921, attending our ongoing preventive medical health screening program in Malmö. Both COHb% and CO showed great interindividual variations in the smokers; potentially of value as a complement to smoking history to identify smokers at high risk of tobacco-related diseases. They also provide powerful arguments for quitting smoking. Therefore, CO is now measured and discussed by the nurses as part of the screening investigation in all smokers. Neither COHb% nor CO showed correlations to the AHH induction levels. There were no associations between the latter and the smoking category, which supports that AHH inducibility is under genetic control. However, high AHH induction in smokers implies an increased risk of smoking-induced carcinogenesis. Smokers with high AHH inducibility identified in the screening have, therefore, been invited to antismoking information and counselling.

Aryl Hydrocarbon Hydroxylases↗