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Biomedical subjects

L Jakab

Publications and source records attributed to L Jakab.

At least 73 records · Page 4Linked to original sources
PubMed1980

Serum proteins in processes associated with an increase in the monoclonal and polyclonal immunoglobulin levels.

The sera of patients with IgG-myeloma, IgM-macroglobulinaemia and with processes accompanied by high polyclonal Ig-levels were measured by radial immunodiffusion for immunoglobulins, coeruloplasmin, alpha-2-macroglobulin, C3-component, transferrin, alpha-1-antitrypsin, alpha-2-haptoglobin and haemopexin. In the presence of typical changes in the immunoglobulin concentrations, elevation of alpha-2-macroglobulin was found only if polyclonal Ig was increased. The concentration of the C3 component was reduced only in IgM macroglobulinaemia, that of transferrin only in IgG-myeloma, that of alpha-2-haptoglobin only in IgM-macroglobulinaemia and in case of increased polyclonal Ig.

Adult↗
PubMed1978

Circulating B and T lymphocytes in chronic active liver disease.

The number of circulating total lymphocytes and the number of B and T lymphocytes from the blood were estimated in 22 patients with biopsy-verified chronic active liver disease. The total number of lymphocytes and the number of rosette-forming cells (T lymphocytes) were decreased in patients with liver disease. The number of IgG,- IgA- and IgM-bearing lymhocytes (B cells) did not change significantly while the number of null cells increased in patients vs. a control group.

Adult↗
PubMed1978

[Immunoglobulins and glycoproteins in lymphogranulomatosis].

In the serum of 27 patients with malignant lymphogranulomatosis the authors determined the serum level of glycoproteid-carbohydrate components (hexose, hexosamine, sialin acid, and seromucoid) and the concentration of 11 different glycoproteids. In the early stage of the disease the immunoglobulin level is moderately increased in the serum, whereas a diminution can be observed in stage IV. The concentrations of ceruloplasmin, alpha-2-macroglobulin and orosomucoid were already increased significantly in stage III. The increase did not continue in stage IV. In the final stage of the disease the concentrations of alpha-1-antitrypsin and haemopexin turned out to be increased considerably. A significant decrease in the transferrin level could be registered in stage III with this diminution also continuing in the further course. Changes of beta-C-globulin and haptoglobin concentrations could not be evaluated statistically. The content of carbohydrate components in the glycoproteids will already increase in the early stage of the disease with this increase continuing in the further course. Among histological types there was a more significant increase of immunoglobulins in those forms rich of lymphocytes.

Adult↗
PubMed1977

[Serum immunoglobulin and glycoprotein concentration and mesenchymal reaction in chronic hepatitis and liver cirrhosis].

In the liver needle biopsy specimens of 45 patients with hepatitis chronica persistents, hepatitis chronica aggressiva and cirrhosis of the liver the number of lymphoid cells and fibroblasts, and in the serum of the same patients concentration of IgG, IgA, IgM, alfa-2-macroglobulin and coeuroplasmin was examined. It was established that 1. the number of lymphoid cells and fibroblasts in the liver tissue of patients with hepatitis chronica aggressiva and cirrhosis of the liver increases significantly, 2. there exists a correlation between the number of lymphoid cells and the concentration of IgG, 3. the serum level of the alfa-2-macroglobulin increases parallely with the number of fibroblasts of the liver in hepatitis chronica aggressive and in cirrhosis of the liver.

Ceruloplasmin↗
PubMed1976

Effect of immunosuppressive therapy on the serum glycoprotein levels in chronic aggressive hepatitis.

The sera of 24 patients with chronic aggressive hepatitis receiving combined immunosuppressive therapy were studied for the concentrations of the carbohydrate components of glycoproteins and the IgG, IgA, IgM, alpha-2-macroglobulin, coeruloplasmin, beta-1-C-globulin and transferrin levels over a period of 2 years. Liver biopsy was performed repeatedly in 50% of the cases. On the evidence of the results, combined immunosuppressive treatment is regarded as apt to normalize the serum concentrations of IgG, IgA, IgM and to reduce those of alpha-2-macroglobulin and coeruloplasmin. Among the carbohydrate components of glycoproteins only the amount of hexose was reduced.

Adult↗
PubMed1976

Serum lipids and lipoproteins in chronic liver disease.

Serum cholesterol, triglyceride, total lipids and the lipoprotein pattern were studied in 169 cases chronic liver disease confirmed by biopsy. On the ground of the immunological and morphological results the patients were classified into five groups. In chronic persistent hepatitis no significant abnormality was found. In chronic aggressive hepatitis and in cirrhosis of the liver the serum cholesterol level was significantly reduced. In fatty infiltration of the liver the serum cholesterol, triglyceride and total lipid concentrations were significantly increased, as compared with the normal values and with the figures obtained in the cases of chronic inflammatory liver disease. In the cases of cirrhosis with additional diabetes the lipid values were likewise increased. In chronic aggressive hepatitis and in cirrhosis of the liver the levels of pre-beta and alpha lipoprotein were decreased, in fatty infiltration of the liver those of beta and pre-beta lipoprotein were increased.

Adolescent↗
PubMed1976

Chronic hepatitis; prognostic aspects.

Chronic hepatitis was diagnosed on the basis of biochemical, immunological and morphological criteria in 153 cases. On the evidence of observations for a mean period of four years the prognosis of chronic persistent hepatitis is regarded as favourable, no progression to chronic aggressive hepatitis or to cirrhosis having been observed in any of the cases. On the other hand, chronic aggressive hepatitis was found to progress to cirrhosis in 12 out of 65 cases. Cirrhotic transformation was more frequent in hyperactive processes (8 out of 25 cases). The sera of patients with primary hepatocellular carcinoma showed low immunoglobulin concentrations, with increased coeruloplasmin and reduced transferrin levels.

Adolescent↗
PubMed1976

Serum glycoproteins in autoimmune diseases.

The concentration of IgA, IgG, IgM, coeruloplasmin, alpha-2-macroglobulin, beta-1-C-globulin, transferrin as well as of alpha-2-haptoglobin, orosomucoid and haemopexin has been studied in the serum of patients with disseminated lupus erythematosus, chronic progressive polyarthritis and immunopathological syndromes. The concentration of the carbohydrate components bound to serum proteins was also determined. In disseminated lupus erythematosus, the concentration of IgA, IgG, IgM, coeruloplasmin, and hexose, hexosamine and sialic acid bound to proteins, as well as of seromucoid was increased. In chronic progressive polyarthritis the IgA, IgG, IgM, coeruloplasmin, alpha-2-macroglobulin and beta-1-C-globulin concentration and the carbohydrate components bound to serum proteins rose. In immunopathological syndromes, too, the serum IgA, IgG, IgM, coeruloplasmin, and protein-bound hexosamine and sialic acid levels were increased. Under the effect of treatment, the elevated glycoprotein concentrations usually decrease, but the level of carbohydrate components bound to serum proteins hardly changes. The pathogenic and diagnostic significance of serum glycoproteins is discussed.

Adult↗