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Biomedical subjects

L Jakab

Publications and source records attributed to L Jakab.

At least 37 records · Page 2Linked to original sources
PubMed1997

[Relapsing polychondritis associated with myelodysplasia and acute eosinophilic leukemia].

Authors report a case in which relapsing polychondritis had been diagnosed two years before myelodysplastic syndrome developed and terminated in eosinophilic leukemia. The observation that relapsing polychondritis may precede myelodysplasia is not in concordance with some of the previous reports regarding relapsing polychondritis as a paraneoplastic phenomenon of myelodysplastic syndrome. The terminally developed eosinophilic leukemia is not supposed to be a blastic phase of the underlying myelodysplasia, much rather a second malignant process. This opinion may be confirmed by the early presence of blast cells in the myelodysplastic process without eosinophilia. It seems interesting to note that both our patient and his daughter suffered from diseases of autoimmune origin: acquired vitiligo and subacute cutan lupus erythematodes, respectively.

Aged↗
PubMed1996

[Acute pancreatitis: inflammatory response of the body].

The author reviews the most important data related with the pathogenesis of pancreatitis acuta, the pathological characteristics, the clinical development of the disease, the more frequent complications are summarized. Within this scope the evolutionary mechanisms of the organ damages are discussed, the diagnostic and prognostic relations are delineated, too. Particular attention is paid to the development and regulation of the defending, preventing reactions of the organisms connected with pancreatitis acuta. The process of leukocyte emigration into the tissue being shortly summarized, the acute phase reaction of the organism and the pathophysiological, clinical significance of the acute phase reactants are likewise presented. The author deals distinctly with the physiological, pathophysiological functions of alpha 2-macroglobulin and with its significance in pancreatitis acuta. The therapeutic outlooks are in a few words touched upon. The acute phase reaction of the organism is inserted in the framework of the possible types of the protecting, preventing responses of the organism.

Acute Disease↗
PubMed1995

Effect of various levels of T-2 toxin in the immune system of growing pigs.

Four groups of seven-week-old pigs weighing about 9 kg were fed for three weeks a prestarter that contained 0.5, 1.0, 2.0 or 3.0 mg/kg of highly purified T-2 toxin. The average daily intakes of toxin by the pigs were 0.38, 0.81, 1.24 and 1.43 mg, respectively. The experimental and control pigs were immunised with 5 ml aluminum hydroxide gel-absorbed purified horse globulin on the first and fourth days of the treatment period. Blood samples were withdrawn on days 7, 14 and 21 and used for the determination of the titre of anti-horse globulin antibody, for an in vitro lymphocyte proliferation test, using purified horse globulin, phytohaemagglutinin and concanavalin-A and for determinations of the immune complex, the cytotoxic reaction and the phagocytic activity and phagocytic index of circulating granulocytes. The samples taken on day 21 were also used to determine the erythrocyte count, the mean cell volume of the erythrocytes, the haematocrit, the blood haemoglobin concentration, the leucocyte count and the proportion of T lymphocytes. At the end of the experiment samples were taken from the thymus, spleen and mesenteric lymph nodes for histological examination. The diets that contained 2 and 3 mg T-2 toxin/kg caused a significant decrease in the red blood cell count, the mean corpuscular volume and the haemoglobin concentration. A significant decrease in the leucocyte count and the proportion of T lymphocytes was observed in all the treatment groups. There were also dose-dependent, significant decreases in antibody formation and in the blastogenic transformation of lymphocytes, and mild to moderate reactive processes were observed histologically in the lymphoid organs.

Animal Feed↗
PubMed1995

Effect of various levels of T-2 toxin on the clinical status, performance and metabolism of growing pigs.

In two sets of experiments eight groups of seven-week-old pigs weighing about 9 kg were fed for three weeks a prestarter that contained 0.5, 1.0, 2.0, 3.0, 4.0, 5.0, 10.0 or 15.0 mg/kg of highly purified T-2 toxin. The feed of the two control groups was free from T-2 toxin. Average daily intakes of toxin by the pigs were 0.38, 0.81, 1.24, 1.43, 0.93, 0.81, 0.99 and 2.5 mg, respectively. The weight gains, the feed intakes, the extent of feed refusal, the parameters of energy and protein metabolism and the serum concentrations of calcium, inorganic phosphorus and magnesium were affected to different extents by the different doses of T-2 toxin, but the data indicated that feed consumption was reduced and the activity of aspartate aminotransferase was increased by the smallest amount of T-2 toxin tested.

Animal Feed↗
PubMed1993

[New aspects of the pathogenesis of progressive chronic polyarthritis (rheumatoid arthritis)].

The author summarizes the newest results and knowledges which are related to the pathogenesis of polyarthritis chronica progressiva. Pursuing the composed target the feasible roles of gamma delta TcR T lymphocytes and stress proteins as well as that of CD5 positive B lymphocytes and IgG-glycosylation status are discussed. Reaching the end of the paper it is established that the solution of etiology and pathogenesis of polyarthritis chronica progressiva, in spite of the increasing theoretical knowledge, awaits for further extensive research work.

Arthritis, Rheumatoid↗
PubMed1993

[Acute phase reaction of the body].

l" with the concept, interpretation and function of the acute phase reaction of the organism. He sums up the general constructive elements of the acute phase response of the organism, the correlations of the specific and non specific defensive mechanisms. He refers slightly in detail to the questions correlating with the structure and biologic functions of the acute phase proteins. Finally the most important criteria of the especially known acute phase proteins are presented.

Acute-Phase Proteins↗
PubMed1992

[Diagnostic value of the determination of serum alpha2-HS-glycoprotein].

Opsonic glycoprotein, alpha 2-HS-glycoprotein concentration was studied in the serum of 753 patients with various hematological, malignant, immunological, metabolic, endocrine and liver diseases and 68 healthy controls. Decreased serum alpha 2-HS-glycoprotein levels were detected in patients with acute leukemias, chronic granulocyte and myelomonocyte leukemias, lymphomas, myelofibrosis, multiple myeloma, metastatizing solid tumors, systemic lupus erythematosus, rheumatoid arthritis, acute alcoholic hepatitis, fatty liver, chronic active hepatitis, liver cirrhosis, acute and chronic pancreatitis, and Crohn's disease. Elevated levels were measured in patients with B and NANB/C hepatitis. Further decreased levels were observed in some groups with secondary infections. Serum alpha 2-HS-glycoprotein levels are affected by many factors, influencing the synthesis and elimination of the protein. The detection of serum alpha 2-HS-glycoprotein concentration has no specific diagnostic value as a marker for tumors or other diseases, however, its determination can be useful for the assessment of a non-specific regulator of the host defence.

Blood Proteins↗