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Biomedical subjects

L J Alexander

Publications and source records attributed to L J Alexander.

88 records · Page 5Linked to original sources
PubMed1985

The prevalence of macular drusen in a population of patients with known insulin-dependent diabetes mellitus.

This paper describes the prevalence rates of macular drusen in a population of known insulin-dependent diabetic patients. The prevalence rate was found to be higher in the insulin-dependent diabetic than population bases in previous studies. There also is a suggestion that the presence of diabetic retinopathy does not increase the likelihood of macular drusen but that cardiovascular disease and/or hypertension may have a positive effect on the development of macular drusen.

Adolescent↗
PubMed1985

The prevalence of the ocular side effects of chlorpromazine in the Tuscaloosa Veterans Administration patient population.

Ninety-five patients were examined between the ages of 25 and 74 years of age at the Tuscaloosa Veterans Administration Hospital and the University of Alabama at Birmingham School of Optometry. Of the 95 patients 54.7% had never taken chlorpromazine and 45.3% were taking chlorpromazine. We analyzed the prevalence of ocular side effects of chlorpromazine and found that the most prevalent side effect was anterior lens capsule dusting followed by corneal stromal pigment dusting. Both of these changes occurred at a lower cumulative dosage level than had previously been reported. The prevalence of anterior corneal epithelial opacification, anterior corneal staining, cataracts, and pigment in the macula is also reported.

Adult↗
PubMed1983

Ocular signs and symptoms of altered blood lipids.

Several eye signs may present secondary to altered blood lipid levels. It is important to recognize these signs and their implications relative to both primary and secondary hyperlipoproteinemias. The significance of corneal arcus is age related, while isolated xanthelasma implies altered blood lipid levels in 30-50% of the cases. Eruptive xanthomas imply triglyceride levels in excess of 1500 mg% while lipemia retinalis presents when triglyceride levels exceed 2500 mg%. Retinal emboli present as a sign of an eroding atheroma and as such an indicator of the possibility of an impending stroke. Altered blood lipid levels represent a threat to life and must be recognized as early as possible to institute therapy. Therapy may be directed to either the primary or secondary causes of hyperlipoproteinemias.

Adult↗
PubMed1982

Low risk of contrast media-induced acute renal failure in nonazotemic type 2 diabetes mellitus.

The risk of developing contrast media-induced acute renal failure was studied in 49 randomly selected nonazotemic type 2 adult diabetic patients subjected to IVU. There were 19 men and 30 women in the group whose mean age was 62 +/- 10 years (range, 38 to 82 years). In preparation for IVU, patients were neither dehydrated nor given a laxative. The IVU was performed in the morning, using sodium diatrizoate and meglumine diatrizoate. Serum creatinine levels were measured pre-IVU and on days 1, 3, and 6 after the IVU. A total of three patients (6%) had an elevation of serum creatinine greater than 25% above the baseline by post-IVU day 3. One patient developed oliguria (less than 400 ml/24 hr) that lasted 2 days. Creatinine clearances of the three patients showing contrast media toxicity were 74, 60, and 105 ml/min pre-IVU. In each of the three patients, a return to pre-IVU serum creatinine concentration was noted within 2 weeks. It is concluded that the risk of acute renal failure post-IVU is small in hydrated nonazotemic type 2 diabetic patients.

Acute Kidney Injury↗
PubMed1982

Blood glucose testing.

Data presented in this study indicates that the following systems; Eyetone-Ames, Dextrometer-Ames, Chemstrip bG-BioDynamics, and Stat Tek-BioDynamics, perform with accuracy in the estimation of blood glucose as compared to the results of the Beckman Auto-Analyzer. The Dextrostix-Ames system did not provide the accuracy necessary for blood glucose screening.

Blood Chemical Analysis↗
PubMed1980

Nucleotide sequence of Lactobacillus viridescens 5S RNA.

The nucleotide sequence of Lactobacillus viridescens ATCC 12706 5S RNA was determined to be pU-G-U-U-G-U-G-A-U-G-A-U-G-G-C-A-U-U-G-A-G-G-U-C-A-C-A-C C-U-G-U-U-C-C-C-A-U-A-C-C-G-A-A-C-A-C-A-G-A-A-G-U-U-A-A-G-C-U-C-A-A-U-A-G-C-G C-C-G-A-A-A-G-U-A-G-U-U-G-G-A-G-G-A-U-C-U-C-U-U-C-C-U-G-C-G-A-G-G-A-U-A-G-G-A C-G-U-C-G-C-A-A-U-G-COH. When compared with other published sequences of prokaryotic 5S RNA species, this sequence shows as much homology with that from B. substilis (80% homology when all variations included) and B. megaterium (77% homology) as with the 5S RNA from another member of Lactobacillaceae family (L. brevis, 79% homology). The sequence contains the proposed tRNA binding site (CGAAC, positions 41-45) and can accomodate most, but not all, of the more recently proposed helical regions of secondary structure.

Bacillus megaterium↗
PubMed1980

Pre-retinal membrane formation.

Pre-retinal membranes often present ophthalmoscopically without subjective symptoms. These membranes can present a diagnostic dilemma. The following discussion addresses the probable pathogenesis of these membranes, their clinical detection, and the proper clinical management.

Adult↗
PubMed1978

Automated perimetry.

The history, theory, and practical application of automated perimetry are discussed. Optometrists are urged to consider increasing the efficiency of their examination procedures by using automated field testing--in particular, automated perimetry.

Humans↗
PubMed1977

Use of "black light" in assesing pupillary responses.

A modification of the conventional technique of pupillary analysis that maximizes the ability of the clinician to interpret papillary abnormalities, especially in aging patients, is presented. The technique, which utilizes the principle of lenticular fluorescence from "black-light" (ultraviolet) stimulation, employs equipment that is readily available to clinicians.

Age Factors↗