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Biomedical subjects

L J Alexander

Publications and source records attributed to L J Alexander.

At least 73 records · Page 4Linked to original sources
PubMed1992

The sequence of porcine beta-casein cDNA.

Porcine cDNAs clones encoding beta-casein were isolated and sequenced. The porcine beta-casein cDNA is 1100bp in length, excluding the poly(A) tail, and encodes a preprotein of 232 amino acids.

Amino Acid Sequence↗
PubMed1992

Ocular vitamin therapy. A review and assessment.

Vitamin therapy for diseased conditions of the eye has regained momentum in the United States, especially for the treatment of age-related macular degeneration. This review looks at the potential effects of vitamin therapy as it relates to everyday primary eye care practice. The discussion covers the generalities of vitamins, their actions, and potential toxicities. In addition, specific attention is paid to the ocular conditions that have been proposed as benefiting from oral and topical vitamin therapies. The analysis is made on a clinicopathological basis rather than being drawn from anecdotal accounts and unsubstantiated claims.

Eye Diseases↗
PubMed1992

The sequence of porcine alpha s2-casein cDNA.

cDNA clones encoding the entire porcine alpha s2-casein message were isolated and sequenced. The porcine alpha s2-casein cDNA is 1093 bp, excluding the poly(A) tail, in length and encodes a preprotein of 235 amino acids.

Amino Acid Sequence↗
PubMed1992

Variations in physician response to consultation requests for Hollenhorst plaques: a pilot study.

This is a report on physicians' response to a pilot survey regarding the method of management of a patient sent to them for a health evaluation because of a Hollenhorst plaque detected during a routine eye examination. Several specialties and sub-specialties were surveyed. The results demonstrate a wide variability in the methods chosen for management of the patient, indicating the need to consider standardizing the health evaluation. A review of literature suggests that the patient with a Hollenhorst plaque is at increased risk for both cardiovascular and cerebrovascular disease and appropriate measures should be taken to minimize the risk. The pilot survey suggests that more in-depth surveys are necessary to establish standards of care for the patient with Hollenhorst plaques as well as other ocular conditions related to systemic disorders.

Arteriosclerosis↗
PubMed1992

Stroke.

Stroke is a primary cause of death and debilitation in the United States. There is both a geographical and race distribution throughout the country. A major health initiative over the next few years is to further reduce the incidence of stroke, especially in the STROKE BELT. There are several "eye signs" of impending stroke including transient monocular blindness, retinal vascular occlusive diseases, ischemic retinal syndromes, visual field defects and retinal emboli. Optometrists can serve as a first line of defense in the death and debilitation from stroke by the recognition of the "eye signs" associated with the most common variant of stroke--the thromboembolism. The primary care provider must also provide recommendations regarding the proper consultation to avert a total stroke.

Cerebrovascular Disorders↗
PubMed1991

The secondary glaucomas.

Glaucoma resulting from secondary congenital, ocular, or systemic conditions represents a formidable diagnostic and management challenge for optometrists. This paper discusses the pathogenesis, diagnosis, and treatment of six common forms of the disease: exfoliation syndrome, pigmentary glaucoma, neovascular glaucoma, lens-induced glaucoma, glaucoma accompanied by ocular inflammation, and trauma-induced glaucoma. For each of these conditions, clinical experience, observational skills, and an understanding of the mechanisms by which elevated intraocular pressure may result are prerequisites for accurate diagnosis. Management requires that the intraocular pressure be reduced and that the underlying condition be diagnosed so that other appropriate treatment may be initiated. Follow-up is predicated on risk factors, relative control of the intraocular pressure, and the fragility of the optic nerve.

Adrenergic beta-Antagonists↗
PubMed1991

Low-tension glaucoma.

Explore the source record for details and available documents.

Adrenergic beta-Antagonists↗
PubMed1991

Diagnosis and management of primary open-angle glaucoma.

Primary open-angle glaucoma offers a significant diagnostic and management challenge for primary care providers. Uncertainty clouds the definition of the disease, its prevalence, the sensitivity and accuracy of the clinical tests used for its diagnosis, the efficacy of antiglaucoma medications, the compliance of patients with these drug regimens, the appropriate use of follow-up examinations, and the use of surgical techniques in lieu of medical management. This discussion addresses these many vexing issues for the purpose of assisting primary care providers to better diagnose and manage glaucoma patients.

Fundus Oculi↗
PubMed1988

Isolation and characterization of the bovine kappa-casein gene.

1. The bovine kappa-casein gene has been isolated as a series of overlapping lambda clones and shown to consist of five exons distributed over a total length of approximately 13 kb. Most of the mature protein-coding sequence is contained in a single large exon. 2. Approximately 65% of the gene has been sequenced together with portions of the 5'- and 3'-flanking sequences. The immediate 5'-flanking sequence contains several motifs which are characteristic of upstream regions including a TATA box, a CAAT box, a sequence similar to that recognized by transcription factor AP-1 and a purine-rich sequence resembling that found upstream in all other lactoprotein genes. Other possible regulatory sequences are found upstream of exon 4. 3. The organization of the kappa-casein gene, together with its upstream sequence, confirms previous conclusions that it is unrelated to the calcium-sensitive-casein gene family to which it is linked. Evidence is presented which supports a previous suggestion that kappa-casein and the fibrinogens are evolutionarily related. 4. Intron sequences contain several examples of the A family of the artiodactyl Alu-like repeated sequences, together with a single example of a C-family sequence. The remainders of the introns of the kappa-casein gene, compared with the repeat elements and exons, are A + T-rich. 5. Among the lambda clones isolated, representatives were found of the A and B genetic variants which can be distinguished by restriction-enzyme analysis. Several other examples of polymorphisms in the non-coding region were found.

Alleles↗
PubMed1988

Clinical and legal issues in the management of patients with diabetes.

Retinopathy is a likely complication of diabetes mellitus, and optometrists who manage patients with diabetes must be prepared to recognize the disease, educate the patient, communicate with the physician treating the disease, and follow up as appropriate to minimize the opportunity for undiagnosed complications. Liability most often results from failure to diagnose diabetic retinopathy, failure to monitor retinopathy adequately, and failure to refer or obtain consultation in a timely manner. Care for patients with diabetes should include appropriate record-keeping and documentation.

Diabetic Retinopathy↗
PubMed1988

Cavernous hemangioma of the retina.

This paper presents an example of a rare clinical entity, a cavernous hemangioma of the retina, with emphasis on the difficulty in differential diagnosis. Relationships with systemic disorders are emphasized. Clinico-pathological schematic drawings accompany photographs to emphasize the importance of differentiating cavernous hemangiomas from retinal telangiectasia, capillary hemangioma and racemose hemangioma. Management of the cavernous hemangioma is routine follow-up examinations and assurance that there are no systemic abnormalities.

Child, Preschool↗
PubMed1987

Clinical and legal aspects of pupillary dilation.

Dilation is an integral part of primary care, and the use of this technique has important clinical and legal implications that should be understood by optometrists. The indications and contraindications for dilation, the selection of the appropriate pharmaceutical agent, the documentation of drug use, and the duty to warn of the effects of mydriasis are aspects of this issue which require the optometrist to comply with the standard of care. In this paper, we offer our personal view of these various obligations, and suggest clinical and legal means of dealing with them.

Dilatation↗