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Biomedical subjects

L Herzberg

Publications and source records attributed to L Herzberg.

At least 19 recordsLinked to original sources
PubMed2000

Dementia with Lewy bodies: a pure case.

A pure case of autopsy-confirmed dementia with Lewy bodies (DLB) is described. The patient presented with distinctive verbal fluency deficits in the context of mild language impairment, intact recognition memory, and impaired paragraph recall. Neuroimaging (CT and SPECT) showed progressive medial temporal lobe atrophy. Neuropathology revealed Lewy bodies, degeneration in the substantia nigra, nucleus basalis of Meynert (Nakano & Hirano, 1984), and locus ceruleus, but no pathology characteristic of Alzheimer's disease. It is in this sense that the case is "pure" DLB. Early neuropsychological diagnosis of DLB is essential (Salmon et al., 1996) given the potentially fatal hazard of neuroleptics (McKeith et al., 1992) and the difficulties associated with clinical neurological diagnoses (Litvan et al., 1998).

Aged↗
PubMed1993

Moyamoya disease: no need for anastomotic surgery?

This paper describes an Australian of Caucasian descent with severe Moyamoya disease. She presented at the age of 34 with a subarachnoid haemorrhage. Between the ages of 45 and 48 she had multiple episodes of cerebrovascular ischaemia. Anastomotic surgery was carefully considered but not undertaken. Ten year follow up showed her to be extremely well without any further episodes of cerebrovascular disease. Accordingly it is recommended that surgery is probably not necessary in some cases, particularly in adults.

Adult↗
PubMed1990

Endocrine aspects of mitochondrial cytopathy: marked phenotypic variation in two affected siblings.

Two siblings with 'mitochondrial myopathy', one of whom was found to have hypergonadotrophic hypogonadism whilst the other had normal endocrine function are reported. The inheritance suggests an autosomal recessive mode. The protean manifestations of the disorder are emphasized. Attention is drawn to the possible association of endocrine abnormalities in addition to the more widely recognized neuromuscular signs.

Adult↗
PubMed1980

Spinal-cord syndrome due to non-compressive Paget's disease of bone: a spinal-artery steal phenomenon reversible with calcitonin.

A 76-year-old man had progressive low back pain, leg weakness, and sensory loss. Radiology showed changes consistent with wide-spread Paget's disease, but no cord compression or involvement of nerve roots was detected by myelography or computerised axial tomography. His symptoms were relieved within 12 days of starting 100 MRC units of subcutaneous salmon calcitonin and recurred when calcitonin was discontinued for 5 days. The improvement continued on calcitonin treatment for 1 year, with falls in serum alkaline phosphatase and urinary hydroxyproline excretion. It is suggested that calcitonin treatment, in reducing the abnormally high metabolic activity of the diseased bone, and hence its vascular perfusion, allows more blood to reach the spinal cord.

Aged↗
PubMed1980

Familial trigeminal neuralgia.

A family had four cases of trigeminal neuralgia occurring in three generations. More cases of a familial nature probably exist.

Aged↗
PubMed1979

Creutzfeld-Jakob disease and corneal grafts.

The possible danger of surgical transmission of Creutzfeld-Jakob disease from one human being to another has been reported in three instances. Although laboratory attempts at transmission of this disease by corneal grafting have so far failed in animals, it is emphasized that great care should be exercised in the selection of donor material for corneal grafts and renal transplants.

Animals↗
PubMed1977

Brain damage and abnormal behaviour in children.

Behavioural problems in children with suspected brain damage may present considerable diagnostic and management problems. Methods of assessment are still imprecise and minor degrees of brain damage are seldom detectable. Data from clinical studies highlight the interrelationship between environmental and organic factors in the pathogenesis of disturbed behaviour. Children from large families of low socioeconomic status, who are subject to parental neglect, are particularly susceptible to the development of psychiatric disorder in the presence of brain damage.

Brain Damage, Chronic↗