Biomedical subjects

L Hardell

Publications and source records attributed to L Hardell.

132 records · Page 8Linked to original sources

PubMedDate not supplied

Multivariate data evaluation of PCB and dioxin profiles in the general population in Sweden and Spain.

Thirty-three polychlorinated biphenyls and 20 dioxin-like congeners were determined by GC-MS in blood and adipose tissue samples from two general population groups, one in Spain (n = 35) and one in Sweden (n = 28). The results were evaluated by multivariate projection (Simca), after normalisation to the most abundant and stable congener in each data set, in order to reveal differences in the "national" congener profiles. The mean values of each population group did not differ significantly. The sum of PCBs in the Spanish was 1450 ng/g and in the Swedish 1310 ng/g. The sum of the dioxin-like compounds in Spain was 1180 pg/g and in Sweden 804 pg/g. The congener profiles differed between the countries. Mainly the higher chlorinated congeners for both the dioxin-like compounds and the PCBs are more dominant in the Spanish group compared to the Swedish.

Adipose Tissue↗

PubMedDate not supplied

Testicular cancer and occupational exposures with a focus on xenoestrogens in polyvinyl chloride plastics.

In a case-control study of 148 cases of testicular cancer and 314 healthy controls information was collected on lifetime working histories and specific exposures. The main finding was a six-fold increase in the risk for seminoma, one type of testicular cancer, among plastic workers exposed to polyvinyl chloride (PVC). No overrisks were observed for other plastics than PVC. There may be an aetiological link to xenoestrogens, i.e. chemicals in the environment with oestrogenic properties. Phthalates are used in PVC as plasticizer and have oestrogenic properties that could promote the growth of endocrine sensitive tumour cells. However, this "endocrine disruptors" hypothesis must be further evaluated in experimental models with regard to the causative mechanisms of the oestrogenic tumour promotion.

Adult↗

PubMedDate not supplied

Background radiation, electrical work, and some other exposures associated with acute myeloid leukemia in a case-referent study.

The effect of potential risk factors for acute myeloid leukemia was evaluated in a case-referent study encompassing 59 cases and 354 referents, all of whom were alive. Information on exposure was obtained through a questionnaire mailed to the subjects. The possible effect of background radiation was evaluated by means of a gamma radiation index, which accounted for the differences between cases and referents in this respect, i.e., in time spent in concrete buildings both at home and at work places. In the 20-54 yr old age group, there was an association between leukemia morbidity and index of background radiation. X-ray treatment and electrical work were also associated with increased rate ratios. With regard to solvents, only styrene appeared as a risk factor, but the number of exposed subjects was small. Other exposures were less clearly associated with increased risks.

Adult↗

PubMedDate not supplied

Increased cancer incidence in physicians, dentists, and health care workers.

Some earlier reports have indicated increased incidence or mortality of specific tumor types in various health care professions. In this study we have evaluated cancer incidence in physicians, dentists, and other health care workers using the Swedish Cancer Environment Register (CER), which was formed by record-linkage between the 1970 census on current occupation and Cancer Register incidence data in 1971-84. In all three profession categories studied an increased risk was found, as well for all malignant tumors combined, as for specific tumor types regarding the different occupations. Possible etiological factors responsible for these risks are discussed.

Allied Health Personnel↗

PubMedDate not supplied

Occupational exposures as risk factors for oral cancer evaluated in a Swedish case-control study.

In a case-control study with 410 cases and 410 matched controls from the period 1980-1989 we investigated the role of occupations and occupational exposures as risk factors for squamous cell oral cancer. All subjects received a questionnaire. The response rates were 96% and 91% for cases and controls, respectively. A significantly increased risk was found for pulp industry workers, odds ratio (OR) 4.0 and wood or product workers, OR 5.5. Exposure to chemicals such as phenoxyacetic acids yielded an OR of 1.7. The positive findings in this study may be explained by exposure to chemicals, but need to be verified in further studies.

Aged↗

PubMedDate not supplied

Previous medical history and medications as risk factors for hairy cell leukaemia.

To investigate the possible role of previous medical history and previous medications as risk factors for hairy cell leukaemia (HCL) we performed a population based case-control study on 121 male HCL patients and 484 controls. The data were collected through a self-administered mailed questionnaire. Elevated odds ratios (OR) were found for a history of appendicitis [OR 1.9; 95% confidence interval (CI) 0.9-4.2] and pneumonia (OR 2.9; CI 0.9-9.6). We found a reduced risk for HCL associated with a history of myocardial infarction (OR 0.3; CI 0.4-2.5), hypertension (OR 0.6; CI 0.3-1.2) and thromboembolic disease (OR 0.6; CI 0.1-2.7). Reduced OR was also associated to a history of diabetes mellitus (OR 0.6; CI 0.1-2.9) and a diagnosis of hyperlipidemia (OR 0.8; CI 0.2-3.6). HCL is an indolent disease with a clinical course of many years and it can not be excluded that the disease leads to metabolic changes, resulting in a changed risk for these diagnoses. When the role of previous medications were investigated, increased OR was found for NSAID (OR 3.4; CI 1.1-10.2). Decreased OR was found for the anti-coagulative agent warfarin (OR 0.4; CI 0.1-1.5). A history of a previous malignancy preceeding the diagnosis of HCL as reported to the Swedish Cancer Registry yielded an increased OR of 3.2 (CI 1.2-8.5). All results must be interpreted with caution, as there is a possibility of misclassification. Medications is difficults to remember, particularly several years after consumption. As many comparisons were made, there is always a possibility of correlations occuring by chance.

Appendicitis↗