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Biomedical subjects

L Hardell

Publications and source records attributed to L Hardell.

At least 127 records · Page 7Linked to original sources
PubMed1983

Epidemiological study of socioeconomic factors and clinical findings in Hodgkin's disease, and reanalysis of previous data regarding chemical exposure.

An association between malignant lymphoma (both Hodgkin's disease (HD) and non-Hodgkin lymphoma) and exposure to organic solvents, phenoxy acids, or chlorophenols was previously reported. A reanalysis of this investigation regarding the cases with HD and exposure to various chemicals was performed and resulted in comparable findings to the whole group of malignant lymphoma. There was an overrepresentation of cases with primary involvement of the gastrointestinal tract which was associated with exposure to these chemicals. The influence of previous diseases and socioeconomic factors was analysed through a supplementary questionnaire to the cases with HD and their matched controls. No differences were found in cases and controls for such variables except for tonsillectomy which was overrepresented among the cases as well as a history of previous duodenal or ventricular ulceration. These findings were, however, insignificant.

Adult↗
PubMed1982

Epidemiological study of nasal and nasopharyngeal cancer and their relation to phenoxy acid or chlorophenol exposure.

Soft tissue sarcoma and malignant lymphoma have been related to exposure to chlorinated phenoxy acids or chlorophenols as well as exposure to organic solvents and malignant lymphoma. However, colon cancer studied by the same case-referent design did not show any such associations, which helps to rule out alleged systematical bias of the study approach. Further considerations about exposure routes for phenoxy acids and chlorophenols suggested that nasal and nasopharyngeal cancers should be studied. Forty-four cases with nasal cancer and 27 cases with nasopharyngeal cancer were eligible for study during 1970-1979 together with 541 referents, as utilized also in the aforementioned studies. Exposure to phenoxy acids gave formally a doubled but insignificant risk for the studied cancer types. Exposure to chlorophenols, as present particularly in woodwork, was related to an about sevenfold and significant increase in the risk for both cancer types. In woodworkers without exposure to chlorophenols there was an approximate normal risk, but cabinet makers, even without exposure to chlorophenols, had nearly doubled (but insignificant) risk of nasal cancer.

Adenocarcinoma↗
PubMed1982

A comment on the reference series with regard to multiple exposure evaluations in a case-referent study.

Case-referent (case-control) studies permit multiple exposures to be considered within the same series of cases and referents (controls) with regard to the etiologic contribution to a certain disease. Specific aspects of validity should be considered however, one being the utilization of an adequate reference series. Should the exposure cause, prevent, or otherwise have a certain relationship to disorders other than the one being studied, individuals with such other disorders cannot be uncritically included in the reference series if obtained from a hospital register, a register of causes of deaths, or some other source of subjects with relations to the individuals' health status. If a general population register is utilized, this problem is avoided since individuals obtained from such a register would adequately reflect the exposure frequency of the source population of the cases. These aspects are well illustrated by a consideration of the use of drugs among cases and, on one hand, referents with some sort of disorder as compared to referents (whether healthy or not) obtained from a population register on the other hand. Studies of industrial exposures seem to be somewhat less sensitive to bias of this type however, since industrial exposures are not primarily disorder-related, whereas drug exposures are.

Adult↗
PubMed1981

Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: a case-control study.

A number of men with malignant lymphoma of the histiocytic type and previous exposure to phenoxy acids or chlorophenols were observed and reported in 1979. A matched case-control study has therefore been performed with cases of malignant lymphoma (Hodgkin's disease and non-Hodgkin lymphoma). This study included 169 cases and 338 controls. The results indicate that exposure to phenoxy acids, chlorophenols, and organic solvents may be a causative factor in malignant lymphoma. Combined exposure of these chemicals seemed to increase the risk. Exposure to various other agents was not obviously different in cases and in controls.

2,4,5-Trichlorophenoxyacetic Acid↗
PubMed1981

Soft-tissue sarcomas and exposure to chemical substances: a case-referent study.

In 1977 several patients were seen with soft-tissue sarcomas and previous exposure to phenoxy acids. This clinical observation resulted in a cases-referent (case-control) study being undertaken which showed that exposure to phenoxy acids or chlorophenols, which are chemically related, gave a roughly six-fold increase in the risk for this type of tumour. A further case-referent study of soft-tissue sarcomas has now been performed to confirm these earlier findings and also to obtain further information on the effects of different phenoxy acids. This new investigation gave an increase of the same magnitude in the risk for soft-tissue sarcomas after exposure to phenoxy acids or chlorophenols, but this risk related also to exposure to phenoxy acids free from impurities, such as polychlorinated dibenzodioxins and dibenzofurans.

Agricultural Workers' Diseases↗
PubMed1981

Relation of soft-tissue sarcoma, malignant lymphoma and colon cancer to phenoxy acids, chlorophenols and other agents.

An association between exposure to phenoxy acids or chlorophenols and soft-tissue sarcoma and malignant lymphoma has previously been reported. An association between exposure to organic solvents and malignant lymphoma has been demonstrated as well. In the present investigation the validity of the assessment of exposure to phenoxy acids and chlorophenols in the previous studies has been further analyzed, partly through a reconsideration of original data and partly through the utilization of another cancer type (colon cancer) for comparison. No observational bias was found which could distort the earlier findings. No significant association was found for these chemicals and colon cancer, whereas exposure to asbestos showed about a twofold increase in risk for colon cancer, an occurrence in agreement with previously reported findings.

Adult↗
PubMed1979

Case-control study: soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols.

In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenols gave an approximately 6-fold increase in the risk for this type of tumour. It was not possible to determine, however, whether the carcinogenic effect was exerted by these compounds or by impurities such as chlorinated dibenzodioxins and dibenzofurans that in almost all cases were part of the commercial preparations.

2,4,5-Trichlorophenoxyacetic Acid↗