Biomedical subjects
Publications and source records attributed to L Giordano.
The clinical problems facing the medical practitioner in the presence of an aspecific granuloma of the caecum were studied. Clinical and aetiopathogenic aspects are analysed as are the indications for surgery. The difficulty of diagnosis and the importance of histopathological assessment for accurate diagnosis are emphasised.
In order to compare the results obtained in terminoterminal and terminolateral intestinal anastomoses using fibrin glue, both fibrin glue and the tissucol KIT were used on a group of rats: comparison of the wounds so treated revealed that both products gave good results. It is claimed that with certain technical improvements the use of fibrin glue could be extended to microsurgery of the nerves and blood vessels.
Twenty-seven chronic schizophrenics and nineteen controls, all male, were evaluated by computed tomography (CT) scans. Lateral, third and fourth ventricles and cerebral density numbers were measured. In the schizophrenic patients there was a significant increase in third ventricle width, Ventricular Brain Ratio (VBR) and there were significantly higher densities of white matter in the right frontal and parietal region.
In order to evaluate the peculiar features of a population of compulsorily admitted (CA) versus voluntarily admitted (VA) schizophrenics, the psychopathological status, disability measure and sociodemographic characteristics were recorded for the two studied groups. Among other assessed variables only the total score of the Current Behavioral Schedule (CBS), used as a global index of impairment, differentiated the two groups, CA patients being the more severely impaired. The severity of the CBS measure correlated with the length of current hospitalization in the CA but not in the VA group.
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The relationship between the degree of intramural infiltration and the aspect and macroscopic dimensions of stomach cancer is investigated in the light of personal experience and reports in the literature. Statistics in the literature suggest that the choice between total and subtotal gastrectomy is only available in antropyloric cancers.
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40 patients with benign paraproteinemia have been studied in relation to their age and associated diseases. Significantly high frequency of liver diseases (CALD, cirrhosis, hepatoma, metastases) has been found (12 over 40 people) and increased incidence of idiopathic paraproteinaemia in the old age has been confirmed. 9 patients have been followed for 5 years, so that one could be sure that they had really benign paraproteinaemia: these patients have been then studied from an immunological point of view, in vivo by means of skin tests (PPD, Candida, Trichophyton, DNCB) and in vitro by searching for circulating immune complexes (using a new highly specific immuno-enzymatic method), and compared to controls without paraproteinaemia. Highly positive skin tests have been found only in 7 over 9 patients (even in old subjects) and 6 of them had circulating immune complexes (C.I.C.) in their sera; all the controls were negative both for skin tests and for C.I.C. Immune complexes have been found also in some cases of idiopathic paraproteinaemia, so that they do not seem to be in relation to the associated diseases. The Authors suggest that a genetically determined defect in regulator/suppressor T lymphocyte activity may cause the growth of a benign B cell neoplasm; and that monoclonal immunoglobulins most probably have antibody specificity and are directed against target antigens.
The synthesis of a series of alkyl and aryl ureas (II) starting from 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane is described. Some of these compounds showed a moderate hypotensive activity in rats. Effects on heart rate in rats, infiltration anesthesia and antiarrhythmic activity in mice, as well as antiacetylcholine activity in vitro, are also reported.
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In vitro researches documented that reproterol, as well as salbutamol, is a powerful stimulant of adenyl cyclase activity in the trachea and bronchi but less potent than isoprenaline. The stimulation was antagonized by beta-blockers.
Experimental investigations have shown that inosine enhances purinergic reactivity. This was examined with adenosine at the level of the cardiovascular, intestinal and uterine musculature. The mechanism of this activity may probably be inhibition of uptake without significantly altering serum adenosinase.
Alcohol decreases myocardial contractility through direct, toxic effect. Ingestion of more than 150 g per day for more than 10 years carries a high risk of developing alcoholic cardiomyopathy. The discontinuance of alcohol intake--if put into effect early in the natural history of patients with alcoholic cardiomyopathy--commonly but not invariably results in remission of heart failure. In order to evaluate the left ventricular (LV) function and to find out a possible correlation between the degree of cardiac dysfunction and the severity of the morpho-functional aspects of alcoholic liver disease, 20 chronic alcoholic patients without clinical evidence of heart disease were examined. Echocardiography, systolic time intervals, mechanical polygraphic recordings and liver biopsy were obtained. According to the morphological alterations showed by the needle biopsy of the liver, we separated 12 patients with liver steatosis (Group I) from 8 subjects with alcoholic hepatitis and fibrosis. In Group I LVET, ICT, PEP/LVET indices and LV fractional shortening (delta %) were not statistically different from control subjects. Patients of Group II showed marked impairment of myocardial function, as revealed by significant ICT, PEP, PEP/LVET prolongation and by an equally significant reduction of fractional shortening of the LV. The noninvasive method has proved to be quite useful in detecting early LV dysfunction in asymptomatic chronic alcoholics and has revealed a correlation between the severity of the morphological involvement of the liver and the impairment of cardiac performance.
We determined by comparison, in 30 patients with arteriosclerosis obliterans and in 10 normal peoples, 50-70 years aged, the values of some glycolipidic parameters (blood glucose, triglyceridemia, cholesterolemia, nephaemia, beta- and pre-beta-lipoproteinemia) and moreover the hormonal ones (IRI, GH, cortisolemia) at fast in the morning, during the whole day and during some blocking and stimulating tests. Patients with arteriosclerosis obliterans presented a significant alteration of the lipidic outline (hyper-lipoproteinemia of IV type sec. Fredr) and of the carbohydrate metabolism, emphasized at the OGTT by a dissimilar tolerance (normal, borderline and pre-diabetic type) referring to a normal high and low insulin immission respectively. We dissert widely about biohumural data, as reflexes involved from the pancreatic function and from the ischaemic process, and we report the eventual tie between the detected hormone-metabolic disorders and the development of arteriosclerotic occlusive disease in the lower extremities.
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In vitro in vivo reproterol showed intense spasmolytic effects upon the trachea and bronchi against various spasm-including agents (histamine, acetylcholine, acetyl-beta-methylcholine, 5-hydroxytryptamine, BaCl2). A comparative study with various drug used in the treatment of asthma (isoprenaline, metaproterenol, salbutamol, clenbuterol, papaverine and atropine) has been conducted.