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Biomedical subjects

L G Keith

Publications and source records attributed to L G Keith.

78 records · Page 5Linked to original sources
PubMedDate not supplied

Maternal characteristics of women delivered of twins: natural vs. induced.

This study retrospectively compared sociodemographic and anthropometric data, as well as selected obstetric outcomes, of 13 mothers of twins who conceived after ovulation induction with clomiphene citrate or Pergonal with similar data from 255 mothers who conceived naturally. Infertile women were significantly (P < .011) older and likely to be married, of the white race, and more educated than women who conceived naturally. Treated women were also taller and heavier prior to conception (NS). Treated women gained significantly more weight (45.9 lb vs. 30.1 lb). They also had a higher proportion of gestations > 32 weeks (91.7% vs. 74.1%) and longer mean gestations (36.5 weeks vs. 35.4 weeks) compared to naturally conceiving mothers of twins, but neither of these differences was significant. The infants of treated mothers had birthweights 9.5% heavier than the infants of mothers who conceived naturally. These retrospective findings suggest that previously infertile women who conceive twins do not suffer worse reproductive outcome than women who conceive naturally.

Adult↗
PubMedDate not supplied

Hemothorax after Lupron therapy of a patient with pleural endometriosis--a case report and literature review.

BACKGROUND: Pulmonary endometrial implants, although uncommon, have been well described in the literature. Symptoms occur with menses and may include recurrent pleuritic chest pain, pneumothorax, hemoptysis, or hemothorax. Exacerbation of pulmonary symptoms by Lupron therapy has not been previously described. CASE REPORT: A 38-year-old African-American female with known endometriosis but no history of pulmonary disease was evaluated for a 2-year history of severe dysmenorrhea. A trial of hormonal suppression was unsuccessful, and she was offered Lupron therapy. Three weeks after its initiation, and shortly after the onset of menses, she came to the emergency room with pleuritic chest pain and shortness of breath and was found to have a right-sided hemopneumothorax. Thoracentesis treatment was successful in eliminating this symptom. CONCLUSION: Although pulmonary endometriosis is rare, physicians should be aware that Lupron therapy can exacerbate pulmonary symptoms during the initial phase of therapy.

Adult↗
PubMedDate not supplied

Generics: what's in a name?

Historically, the most common intervention performed by physicians has been the writing of a prescription. Often the prescription was a combination of active agents and an inactive base. This art is no longer practiced in the United States. Currently, most prescriptions are written for specific "drugs." As the prescription is being written, the physician must decide to administer a brand-name or a generic equivalent. Generics are a class of medications prescribed for reasons of economy, and the physician and the patient expect that the therapeutic effect will be exactly the same as for the brand-name. Bioequivalence of specific agents can be assessed using the FDA's Orange Book. In addition to bioequivalence, many other scientific, ethical, and economic issues should be considered before a decision is made. Prescribing vigilance is necessary, because in many instances available information is often controlling or insufficient to support rational decisions. Brand-names, rather than generics, should be selected when the therapeutic index is narrow or if the likelihood of generic switching is high. The paper will discuss all aspects of the subject.

Chemistry, Pharmaceutical↗