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Biomedical subjects

L Fabre

Publications and source records attributed to L Fabre.

At least 19 recordsLinked to original sources
PubMed1992

Age- and sex-related changes in Tyr-MIF-1-like immunoreactivity in rat plasma.

The concentrations in plasma of the biologically active endogenous peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) have not been measured during development or in female rats. By radioimmunoassay, we found that Tyr-MIF-1-like immunoreactivity (Tyr-MIF-1-LI) was first consistently detectable in plasma when the rat was 5 days old, and then gradually increased to adult concentrations by day 15. In male rats, the levels remained relatively constant for the next 21 months. In female rats, plasma concentrations of Tyr-MIF-1-LI at day 15 were about the same as in male rats. At 6 months of age, however, the concentrations in females decreased by half and by 21 months of life were only about a third of the concentrations found at day 15 or in age-matched males. The differences with age were not due to the length of time of storage of the samples, because another group of rats 1 month old was killed on the same day as 5-day-old rats and still showed several times more Tyr-MIF-1-LI in the plasma; again, no differences were found between male and female rats at either 5 days or 1 month. A single injection of estradiol followed by progesterone lowered the concentrations in 1-month-old male rats. In female rats that were either ovariectomized or sham-ovariectomized, the expected similarity in their plasma concentrations of Tyr-MIF-1-LI was found at 1 month of age.(ABSTRACT TRUNCATED AT 250 WORDS)

Age Distribution↗
PubMed1987

On the diversity of sperm basic proteins in the vertebrates: V. Cytochemical and amino acid analysis in Squamata, Testudines, and Crocodylia.

The variability of sperm basic proteins in representatives of three reptilian orders, Squamata, Testudines, and Crocodylia, has been examined by cytochemistry, acid-urea polyacrylamide gel electrophoresis, and amino acid analysis of amidoblack-stained bands. Snakes contain type 3B intermediate sperm basic proteins by cytochemical criteria. Electrophoresis of basic proteins from epididymis chromatin as well as from testis and ductus deferens cell suspensions shows two fast-moving bands in the vicinity of herring protamine. These proteins are triprotamines containing about 27 mol % arginine, along with lysine and histidine. Lizards have type 1 protamines in their sperm nuclei cytochemically and also show a two-banded electrophoretic pattern similar to that of snakes. However, these proteins are triprotamines, similar to those in snakes with 25 mol % arginine. It may be that these are testis-specific proteins of the spermatid stage in lizards since a cytochemical transition can be observed from type 3A intermediate proteins in spermatids of testis to type 1 protamine in mature sperm of ductus deferens. Turtles contain type 3A intermediate sperm basic proteins cytochemically and basic proteins from epididymis chromatin display both a prominent band and a minor band close to, but slightly slower than, the two bands for snakes and lizards. Amino acid analysis of these bands shows that these basic proteins are also triprotamines but with a higher level of arginine, about 48 mol %, than that in snake and lizard sperm proteins. Basic proteins from epididymis chromatin of a single Mississippi alligator show three main bands moving close to the bands of snakes, lizards, and turtles. These proteins have amino acid compositions typical for triprotamines, with 28-39 mol % arginine. The data indicate that the sperm basic proteins of representatives of 25 species in three reptilian orders are very similar, in contrast to the diversity of sperm protein types found in frogs (Kasinsky, Huang, Kwauk, Mann, Sweeney, and Yee: J. Exp. Zool., 203:109-126, '78; Kasinsky, Huang, Mann, Roca, and Subirana: J. Exp. Zool., 234:33-46, '85a). This appears to be part of a macroevolutionary trend from diversity of sperm basic proteins in frogs to relative constancy in reptiles (Kasinsky, Mann, Pickerill, Gutovich, and Byrd, Jr.:J. Cell Biol., 91:1879, '81; Kasinsky, Mann, Lemke, and Huang: In: Chromosomal Proteins and Gene Expression, Plenum Press, New York, pp. 333-352, '85b). We present the hypothesis that one factor for such a trend resides in the fact that fertilization is internal in reptiles but external in anurans.

Amino Acids↗
PubMed1986

[Recent fractures of the distal end of the femur. Apropos of 87 cases (after the end of treatment)].

Anatomopathologic study of fractures of lower end of femur in 87 patients demonstrated the frequency of compound lesions in adults, epiphyseal detachment being the most common finding in children. Therapy used resulted in consolidation within a mean period of 4 months. Anatomic results were satisfactory in 87% of cases, 2 of 3 patients recuperating a knee compatible with a normal active life. Complications were rare. The current therapeutic attitude in adults is resolutely surgical, particularly in case of an intra-articular fracture line. In children, treatment remains orthopedic, except for epiphyseal detachments when minimal fixation allows perfect anatomic reduction and avoids secondary growth disorders.

Adolescent↗
PubMed1986

[Our concepts of treating recent fractures of the lower end of the humerus in children].

After a brief description of the classification of fractures of lower and of humerus in children, methods are described for the application of different orthopedic and surgical procedures developed over the years. Treatment of supracondylar fractures remains very conventional (Judet's method), experience lacking in the use of contention in strong flexion for these fractures. Emphasis is placed on two points: the need for perfect reduction under all circumstances, since growth will have little impact on correction of residual faults, and the quality and reading of review radiographic images to avoid major mistakes in reduction.

Child↗
PubMed1986

[Fractures of the upper end of radius and ulna and recent dislocations of the elbow in children].

In this report concerned with luxation of the elbow and fractures of the upper end of two forearm bones in children emphasis is placed on the importance of the initial treatment, since sequelae are not corrected during growth. Correct therapy requires firstly a precise diagnosis, this depending on the obtaining of images of very good quality, if necessary taken during sleep if the child has to be anesthetized. Therapy should be as atraumatic as possible, particularly in the region of the head of radius, to avoid its subsequent necrosis.

Child↗
PubMed1979

[Scleroma].

Explore the source record for details and available documents.

Adult↗
PubMed1979

[Carcinoma of the nasal sub-septum (author's transl)].

On the basis of 13 cases, the authors describe the anatomical characteristics and course of primary carcinomas of the nasal sub-septum. This is a transitional form between nasal carcinomas and those of the nasal fossa. The cases described were treated either by conventional radiotherapy (200 Kv) or by electron therapy. The successful results obtained (12/13) confirmed the value of irradiation in this special site, without the risk of radionecrosis. The technique should conform with precise rule, as in all tumours of the face or nasal pyramid and the quality of the results obtained is compared favourable with those of all other methods.

Aged↗
PubMed1976

[An audiometric method for use with children. The cochleo-palpebral reflex can be improved by visual conditioning].

It is possible, even with children and new-born babies, to condition the oculo-palpebral reflex to respond to sound. The apparatus constructed by Messrs. Gasquet and Brun achieves this conditioning on the one hand and, on the other, allows this to be used as a method of visual audiometry. This method generally enables the operator to come within twenty decibels or so of the real threshold compared with the unconditioned cochleo-palpebral reflex threshold. The use of a polygraphic recording technique for palpebral response adds precision to the results of this method, particularly by the demonstration of a phenomenon of anticipation which appears when the conditioning has been achieved. Audiometry by means of conditioning therefore represents an objective technique for detecting deafness in new-born babies.

Audiometry↗
PubMed1971

Metabolic disease in mental retardation: a study in Texas.

Reported are the results of a study of patients admitted to the State Schools for the Mentally Retarded in Texas, over a two-year period from 1968-1970. Of 2029 cases, 185 were found on a detection battery screening to have possible metabolic disease. The report summarizes the findings on 93 cases studied in the metabolic ward at the Texas Research Institute.

Female↗
PubMedDate not supplied

[Primary tumors of the cervico-brachial plexus].

Together with a description of two cases, the authors analyze all the cases they have been able to find in the literature and review the question from the histogenic, the anatomo-pathological, the clinical and the therapeutic points of view.

Adolescent↗
PubMedDate not supplied

[Plasmapheresis and acute attacks of uveitis].

Our study concerns the effects of plasma exchange in acute attacks of posterior or total chronic uveitis. The treatment undertaken in 10 patients consisted of 8 plasma exchanges in a 2 weeks period, associated with a corticosteroid and immunosuppressive therapy. Immediately after the plasma exchanges, there was a significant improvement in visual acuity and a decrease in inflammatory activity in most patients (70%). Plasma exchange seems to be an interesting adjuvant in the difficult treatment of some uveitis.

Acute Disease↗