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Biomedical subjects

L F Montes

Publications and source records attributed to L F Montes.

At least 55 records · Page 3Linked to original sources

Acne vulgaris: treatment with topical benzoyl peroxide acetone gel.

The topical effect on acne of a benzoyl peroxide acetone gel was studied over an eight week period and simultaneously compared with the effect of a benzoyl peroxide lotion and a vitamin A acid cream. The three formulations produced a significant reduction in the number of comedones. The two benzoyl peroxide formulations substantially reduced the number of papules, but this effect was not observed to a significant degree with the vitamin A acid. Burning sensation following application, a common problem with the benzoyl peroxide alcohol gels, was not reported by patients using the benzoyl peroxide acetone gel.

Acne Vulgaris↗

How useful is a biopsy in a case of suspected fungal infection?

In suspected cases of superficial fungal infections, biopsies are not routinely performed. This paper has analyzed some diagnostic features of histopathologic examination in dermatomycosis that are not usually emphasized. The usefulness of light microscopic observation of PAS-stained and plastic-embedded specimens has also been shown.

Biopsy↗

Topical cycloheximide in psoriasis.

Cycloheximide is an antimitotic and an inhibitor of the synthesis of both DNA and protein. Topical application in low concentrations (0.1%-0.2%) resulted in definite involution of psoriatic plaques. Because of its potency this experimental drug - not yet available for clinical use - was employed on small areas only and with extreme caution. Results of a full evaluation for safety, currently in progress, are being awaited with interest.

Administration, Topical↗

Light eruption.

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Adult↗

Condylomata acuminata.

A 5-year-old Thoroughbred chestnut mare was presented because of multiple lesions noticed for approximately one year over the vulva and ther perianal areas. Clinically, there were moist warts that stood out because of their whitish color which contrasted strikingly with the surrounding, normally pigmented, uninvolved skin (Fig. 1). Repeated topical applications of 20% podophyllin in 95% ethyl alcohol produced rapid involution. Histopathologically, marked acanthosis, numerous mitoses, prominently vacuolated epidermal cells and a chronic dermal inflammatory infiltrate were seen (Figs. 2, 3, and 4). Interestingly, melanin in the basal cell layer was not visible in the lesions, but was very apparent in the normal epidermis at the edges of the lesions. Thus the contrast between the affected and the non-affected skin was also strikingly microscopically (Fig. 2 arrows).

Animals↗

Lichen planus.

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Adult↗

Genital candidiasis: topical management with clotrimazole.

Clotrimazole was administered in the form of 100 mg tablets to patients with vaginal candidiasis, and in the form of a 1% solution to patients with cutaneous candidiasis of the genital and perigenital areas. The clinical and mycological response observed and the excellent tolerance and lack of side effects indicate that clotrimazole may be proposed as a treatment for candidiasis.

Administration, Oral↗

Clotrimazole troches: a new therapeutic approach to oral candidiasis.

To ascertain the topical effectiveness of clotrimazole in oral candidiasis, a troche form was administered to 12 patients suffering from longstanding infection. One-half of the patients took one 10 mg troche and the other half of the patients one 50 mg troche, ten times a day. The troches were not chewed, but were retained in the mouth until completely dissolved. The impressive clinical and mycological response to this treatment as well as the lack of toxicity strongly indicate that further trials are warranted.

Administration, Topical↗

Microbial flora of nurses' hands. III. The relationship between staphylococcal skin populations and persistence of carriage.

The hands of 50 nurses and 50 controls were tested for coagulase-positive staphylococcus. Twenty-eight percent of both groups were carriers. The mean staphylococcal count on the palm of the hand was 13.7 per 16 cm-2 in nurses as compared to 442.7 per 16 cm-2 in the control group. The number of persistent carriers was the same for each group, but 25 percent of all cultures from nurses were positive for Staphylococcus aureus as compared to 14.2 percent of the cultures from the control group. It was concluded that there was no direct correlation between high staphylococcal counts and persistence of carriage. The skin as a site of carriage of Staphylococcus aureus was found to be of greater importance in nurses than in control subjects.

Anti-Bacterial Agents↗

Alopecia areata.

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Alopecia Areata↗

Herpes zoster.

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Female↗

Darier's disease.

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Adolescent↗